Patents by Inventor John Ballantyne

John Ballantyne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Baby Hamster Kidney (BHK) Cells Transformed with the Adenoviral E1 Gene for Production of Recombinant Adeno-Associated Virus
    Publication number: 20240263143
    Abstract: Disclosed is the creation of new E1-complementing BHK-21 cell lines to produce recombinant adeno-associated virus (rAAV) vectors. The new cell lines stably express the E1 gene region of adenovirus or a portion thereof and produce the E1 proteins. Transient production in the E1-complementing cell lines of the AAV rep/cap proteins, helper proteins and an AAV transfer plasmid containing the desirable transgene flanked by the Inverted Terminal Repeat (ITR) sequences of AAV, results in production of rAAV particles containing the transgene. Further disclosed is scaled-up production, harvesting and purification of transgene-containing rAAV. The purified rAAV has demonstrated capability to infect a host cell line and express the protein encoded by the transgene. The disclosure provides non-human, non-embryonic cell lines for production of rAAV particles that are a platform for delivery of a desired transgene.
    Type: Application
    Filed: February 1, 2024
    Publication date: August 8, 2024
    Applicant: Agathos Biologics
    Inventors: James Brown, Michael Chambers, John Ballantyne, Jagadish Loganathan, Andrzej Noyszewski, Amber Plambeck
  • Messenger RNA profiling: body fluid identification using multiplex real time-polymerase chain reaction (q-PCR)
    Patent number: 8637654
    Abstract: This invention relates to a ribonucleic acid (RNA) based assay system for body fluid identification, and in particular to a novel, multiplex, parallel assay system based on messenger RNA expressed in human tissue, and to a method for using the same.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: January 28, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: John Ballantyne, Jane Juusola
  • Age determination from biological stains using messenger RNA profiling analysis
    Patent number: 7704693
    Abstract: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin. The methodology is based on gene expression profiling analysis in which novel human newborn fetal specific genes are identified by detecting the presence of appropriate messenger RNA species.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: April 27, 2010
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: John Ballantyne, Michelle Alvarez
  • Messenger RNA profiling: body fluid identification using multiplex real time-polymerase chain reaction (q-PCR)
    Patent number: 7588921
    Abstract: This invention relates to a ribonucleic acid (RNA) based assay system for body fluid identification, and in particular to a novel, multiplex, parallel assay system based on messenger RNA expressed in human tissue, and to a method for using the same.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 15, 2009
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: John Ballantyne, Jane Juusola
  • Age determination from biological stains using messenger RNA profiling analysis
    Patent number: 7276340
    Abstract: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin. The methodology is based on gene expression profiling analysis in which novel human newborn fetal specific genes are identified by detecting the presence of appropriate messenger RNA species.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: October 2, 2007
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: John Ballantyne, Michelle Alvarez