Abstract: Example implementations relate to Additive Manufacturing (AM) pressurization diffusers. An example diffuser includes an integral component configurable for receiving and diffusing pressurant. Particularly, the integral component includes multiple elements manufactured as a single-piece structure, including an inner filter, outer shell, and flange. The inner filter includes micro-diamond holes that enable pressurant received at an opening of the inner filter to diffuse out of the inner filter and subsequently through holes positioned in a shell surface of the outer shell. The flange can position the diffuser such that the opening of the inner filter is in pressurant communication with a pressurant source (e.g., opening of a tank) enabling the diffuser to receive and diffuse pressurant in a predefined pattern.

Abstract: Guide vane check valve assemblies and poppets for guide vane check valve assemblies are disclosed. A guide vane poppet includes an elongate central core configured to form a fluid seal with a valve body of the check valve assembly. The guide vane poppet additionally includes an elongate outer skirt and at least one guide vane radially extending between the elongate central core and the elongate outer skirt. A check valve assembly includes a valve body with a central cavity, an inlet to the central cavity, an outlet from the central cavity, and a spring seat, and further includes a spring and a poppet. The spring is oriented to press against the poppet and to urge a poppet-side sealing surface of the poppet into sealing engagement with a body-side sealing surface of the valve body.

Abstract: Guide vane check valve assemblies and poppets for guide vane check valve assemblies are disclosed. A guide vane poppet includes an elongate central core configured to form a fluid seal with a valve body of the check valve assembly. The guide vane poppet additionally includes an elongate outer skirt and at least one guide vane radially extending between the elongate central core and the elongate outer skirt. A check valve assembly includes a valve body with a central cavity, an inlet to the central cavity, an outlet from the central cavity, and a spring seat, and further includes a spring and a poppet. The spring is oriented to press against the poppet and to urge a poppet-side sealing surface of the poppet into sealing engagement with a body-side sealing surface of the valve body.

Abstract: Example implementations relate to Additive Manufacturing (AM) pressurization diffusers. An example diffuser includes an integral component configurable for receiving and diffusing pressurant. Particularly, the integral component includes multiple elements manufactured as a single-piece structure, including an inner filter, outer shell, and flange. The inner filter includes micro-diamond holes that enable pressurant received at an opening of the inner filter to diffuse out of the inner filter and subsequently through holes positioned in a shell surface of the outer shell. The flange can position the diffuser such that the opening of the inner filter is in pressurant communication with a pressurant source (e.g., opening of a tank) enabling the diffuser to receive and diffuse pressurant in a predefined pattern.

Abstract: A grid stiffened structure which includes a wall which extends in a direction transverse relative to a plane and an elongated rib connected along an elongated dimension of the rib to the wall such that the elongated rib extends along the wall and forms an angle with an axis which extends in a direction perpendicular to the plane. The elongated rib defines a free sidewall which extends from the wall positioned on a first side of the elongated rib and extends in a direction about the elongated rib and transverse to the elongated dimension to the wall positioned on a second side of the elongated rib. The wall and the elongated rib are constructed of a plurality of layers of material which extend in a direction transverse to the axis.

Abstract: Guide vane check valves, guide vane check valve assemblies, and poppets for guide vane check valve assemblies are disclosed. A guide vane poppet includes an elongate central core configured to form a fluid seal with a valve body of the check valve assembly. The guide vane poppet additionally includes an elongate outer skirt and at least one guide vane radially extending between the elongate central core and the elongate outer skirt. A check valve assembly includes a valve body with a central cavity, an inlet to the central cavity, an outlet from the central cavity, and a spring seat, and further includes a spring and a poppet. The spring is oriented to press against the poppet and to urge a poppet-side sealing surface of the poppet into sealing engagement with a body-side sealing surface of the valve body.

Abstract: Example implementations relate to Additive Manufacturing (AM) pressurization diffusers. An example diffuser includes an integral component configurable for receiving and diffusing pressurant. Particularly, the integral component includes multiple elements manufactured as a single-piece structure, including an inner filter, outer shell, and flange. The inner filter includes micro-diamond holes that enable pressurant received at an opening of the inner filter to diffuse out of the inner filter and subsequently through holes positioned in a shell surface of the outer shell. The flange can position the diffuser such that the opening of the inner filter is in pressurant communication with a pressurant source (e.g., opening of a tank) enabling the diffuser to receive and diffuse pressurant in a predefined pattern.

Abstract: A grid stiffened structure which includes a wall which extends in a direction transverse relative to a plane and an elongated rib connected along an elongated dimension of the rib to the wall such that the elongated rib extends along the wall and forms an angle with an axis which extends in a direction perpendicular to the plane. The elongated rib defines a free sidewall which extends from the wall positioned on a first side of the elongated rib and extends in a direction about the elongated rib and transverse to the elongated dimension to the wall positioned on a second side of the elongated rib. The wall and the elongated rib are constructed of a plurality of layers of material which extend in a direction transverse to the axis.

Abstract: Guide vane check valves, guide vane check valve assemblies, and poppets for guide vane check valve assemblies are disclosed. A guide vane poppet includes an elongate central core configured to form a fluid seal with a valve body of the check valve assembly. The guide vane poppet additionally includes an elongate outer skirt and at least one guide vane radially extending between the elongate central core and the elongate outer skirt. A check valve assembly includes a valve body with a central cavity, an inlet to the central cavity, an outlet from the central cavity, and a spring seat, and further includes a spring and a poppet. The spring is oriented to press against the poppet and to urge a poppet-side sealing surface of the poppet into sealing engagement with a body-side sealing surface of the valve body.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.

Abstract: The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants.

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants.