Abstract: Systems and methods are provided for angiographic roadmapping. In accordance with one aspect, the framework generates one or more two-dimensional (2D) digitally reconstructed radiograph (DRR) images from a four-dimensional (4D) digital subtraction angiography (DSA) image volume. A maximally opacified image is generated from at least one of the one or more 2D DRR images over a window of time. The maximally opacified image may then be integrated with a live fluoroscopic image and displayed for angiographic roadmapping.

Abstract: A system comprises a catheter including a lens, for acquiring optical coherence tomography images within the vessel of interest as the catheter is being retracted from the vessel in the presence of contrast agent. An X-ray imaging system interface receives a first set of X-ray images of an anatomical region including the vessel of interest containing the catheter. The first set of X-ray images are acquired at points corresponding to the particular points within a heart cycle, while the catheter is stationary in the vessel, in response to a heart electrical activity representative signal and in the absence of contrast agent. An image data processor associates the received X-ray images and corresponding optical coherence tomography image data derived at corresponding time points within respective acquisition heart cycles.

Abstract: A system and method includes reception of a plurality of fill frames of a patient volume, each of the plurality of fill frames depicting a contrast medium within the patient volume at a respective time, identification, for each pixel location of the fill frames, of a fill frame whose pixel at the pixel location is associated with a pixel value which represents a greater level of contrast medium than the pixel values of pixels at the pixel location within the others of the plurality of fill frames, generation of a peak contrast fill frame corresponding to each fill frame, the peak contrast fill frame corresponding to a given fill frame including, at pixel locations for which the given fill frame was identified, pixels associated with pixel values of the given fill frame, and storage of the plurality of peak contrast fill frames.

Abstract: A system and method includes reception of first two-dimensional projection images of a patient volume, each of the first two-dimensional projection images having been acquired from substantially a respective one of a plurality of projection angles during presence of at least a portion of contrast medium in arteries within the patient volume, reception of second two-dimensional projection images of the patient volume, each of the second two-dimensional projection images having been acquired from substantially a respective one of the plurality of projection angles during presence of at least a portion of the contrast medium in veins within the patient volume, generation, for each of the plurality of projection angles, of a composite two-dimensional image based on one of the first two-dimensional projection images acquired from substantially the projection angle and one of the second two-dimensional projection images acquired from substantially the projection angle, generation of a three-dimensional image based

Abstract: A method and system for tracking blood flow within a vessel of a patient are presented. At least one or more medical images of the patient are acquired showing at least one vessel of the patient. A user marks a proximal point and a distal point on a vessel of interest on the medical images. The vessel of interest is tracked and corrections are made to the tracking using a tracking algorithm. A composite image is generated that encodes time to peak contrast agent intensity at each point of the vessel of interest as well as the intensity of the contrast at that time. A graph of time to peak contrast agent intensity versus distance from a proximal point of the vessel of interest is calculated and displayed to a user.

Abstract: Systems and methods are provided for angiographic roadmapping. In accordance with one aspect, the framework generates one or more two-dimensional (2D) digitally reconstructed radiograph (DRR) images from a four-dimensional (4D) digital subtraction angiography (DSA) image volume. A maximally opacified image is generated from at least one of the one or more 2D DRR images over a window of time. The maximally opacified image may then be integrated with a live fluoroscopic image and displayed for angiographic roadmapping.

Abstract: A system orientates and displays intra-vascular ultrasound imaging data using an acquisition processor and an image data processor. The acquisition processor acquires, during navigation of an ultrasound catheter through a vessel, for multiple individual intra-vascular ultrasound images comprising an image sequence, data representing an individual image and orientation data associated with the individual image indicating orientation of the catheter and individual image with respect to a reference position external to patient anatomy. The image data processor aligns the multiple individual intra-vascular ultrasound images with respect to the external reference position by rotating individual images of the image sequence as necessary to have substantially the same orientation with respect to the external reference position in response to the orientation data.

Abstract: A system and method includes reception of a mask x-ray image of a patient volume, reception of a plurality of sequential x-ray images of the patient volume including a contrast medium, subtraction of the mask x-ray image from each of the plurality of sequential x-ray images to generate a plurality of sequential x-ray difference images, filtering of each of the plurality of sequential x-ray difference images based on one or more filter parameters to generate a plurality of sequential filtered x-ray difference images, combination of each of the plurality of sequential filtered x-ray difference images with a corresponding one of the plurality of sequential x-ray difference images based on a weight to generate a plurality of combined sequential x-ray images, and display of the plurality of combined sequential x-ray images sequentially.

Abstract: A system and method include reception of 3D imaging data showing blood flow over time in a patient volume including vessels, reception of a user input of a projection angle, generation of a plurality of 3D images based on the 3D imaging data, generation of a 2D digitally reconstructed radiograph (DRR) at the projection angle input by the user for one of the plurality of 3D X-ray images, and display of the 2D DRR image. Numerous other aspects are provided.

Abstract: A system enhances reduced resolution grey scale luminance data for display on a monitor. An interface receives a pixel grey scale luminance value represented by a first number of bits exceeding a display monitor input bit length. A data processor indicates a difference comprising the number of bits. In response to the difference, the data processor derives R, G, B pixel luminance values by adjusting one or more of the R, G, B pixel luminance values to provide corrected R, G, B pixel luminance values representing the grey scale luminance value and at least one of the corrected R, G, B pixel luminance values is different from remaining ones of R, G, B pixel luminance values. The data processor outputs the corrected R, G, B pixel luminance values for display on R, G, B channels of the monitor.

Abstract: A method and system for tracking blood flow within a vessel of a patient are presented. At least one or more medical images of the patient are acquired showing at least one vessel of the patient. A user marks a proximal point and a distal point on a vessel of interest on the medical images. The vessel of interest is tracked and corrections are made to the tracking using a tracking algorithm. A composite image is generated that encodes time to peak contrast agent intensity at each point of the vessel of interest as well as the intensity of the contrast at that time. A graph of time to peak contrast agent intensity versus distance from a proximal point of the vessel of interest is calculated and displayed to a user.

Abstract: A medical workflow system is provided that includes at least one database configured to store one or more programs that operate a patient imaging device, patient data corresponding to one or more patients, medical procedure data corresponding to a type of patient medical procedure, and user data identifying a user to conduct a medical procedure using the medical procedure data. The medical workflow system includes a workflow processor configured to determine which of the one or more programs to provide to the user based on at least one of the patient data, the medical procedure data and the user data. The medical workflow system also includes at least one user interface configured to provide a plurality of user selectable options comprising the determined one or more or programs. The workflow processor is further configured to execute a selected program that is selected from the one or more provided programs.

Abstract: A system provides a display image enabling a user to visualize and compare blood flow characteristics over time at selected points in an angiographic X-ray image. A system and user interface enables user interaction with a medical vessel structure image to determine individual vessel blood flow characteristics. The system includes a user interface cursor control device and a display processor for generating data representing a single composite display image. The composite display image includes, a first image area showing a patient vessel structure and contrast agent flow through the patient vessel structure over a first period of time and a second image area showing a graph of contrast agent concentration in a particular portion of the vessel structure over a second period of time. The particular portion of the vessel structure is selected in response to user command using the cursor control device.

Abstract: A system and method includes data representing a sequence of X-ray images of a portion of patient anatomy acquired over a time interval and signal data representing electrical activity of the heart of the patient over the time interval, determination of a score value for each image of said sequence of X-ray images, selection of a set of images from said sequence of X-ray images based on the determined score values, the set of images excluding one or more images of said sequence of X-ray images, and generation of an averaged image from said set of images.

Abstract: A system provides a single composite image including multiple medical images of a portion of patient anatomy acquired using corresponding multiple different types of imaging device. A display processor generates data representing a single composite display image including, a first image area showing a first image of a portion of patient anatomy acquired using a first type of imaging device, a second image area showing a second image of the portion of patient anatomy acquired using a second type of imaging device different to the first type. The first and second image areas include first and second markers respectively. The first and second markers identify an estimated location of the same corresponding anatomical position in the portion of patient anatomy in the first and second images respectively.

Abstract: A system generates medical image data representing smaller vessels including capillaries of a region of patient anatomy. An image data processor identifies pixels of larger vessels in individual images of difference images where the larger vessels have a size exceeding a predetermined threshold size. The image data processor generates an enhanced visualization small vessel image comprising substantially peak luminance values of individual pixels exclusive of pixels of the identified larger vessels. A peak luminance value of an individual pixel is generated in response to a peak luminance value of luminance values of pixels, spatially corresponding to the individual pixel and present in images comprising the plurality of temporally sequential individual difference images. An output processor outputs substantially peak luminance values as a vessel image.

Abstract: A system for selecting an anatomical image for display includes a main image display displaying at least one anatomical image; a touch-screen display; a processing unit providing a selection of graphical directories of anatomical images; and a network configured to interface the main image display with the processing unit and configured to interface the touch-screen display with the processing unit. The system displays at least one of the selection of graphical directories of anatomical images on the touch-screen display and enables selecting at least one of the selection of graphical directories from the processor without removing the anatomical image from the main image display. The touch-screen display includes a button enabling interchangeable display of the anatomical image and the selection of graphical directories of anatomical images. The system enables selecting at least one anatomical image by touching the corresponding image in the directory displayed on the touch-screen display.

Abstract: An IVUS catheter is advantageously provided with a particular radio-opaque pattern enabling detection of catheter rotation angle with respect to an X-ray imaging source for co-registering IVUS image data with angiographic X-ray or CT image data, for example. An ultrasound catheter system supports orientation and display of intra-vascular ultrasound imaging data. The system comprises an ultrasound catheter for acquiring ultrasound images comprising a body having a pattern of radio-opaque material on the external surface of the catheter body. The pattern varies with angular rotation of the catheter and indicates an angle of rotation of a predetermined reference orientation of the catheter relative to an X-ray radiation source, so that an X-ray image of the catheter body indicates the pattern and the pattern is analyzable by an image data processor to determine the angle of rotation.

Abstract: A system and method includes data representing a sequence of X-ray images of a portion of patient anatomy acquired over a time interval and signal data representing electrical activity of the heart of the patient over the time interval, determination of a score value for each image of said sequence of X-ray images, selection of a set of images from said sequence of X-ray images based on the determined score values, the set of images excluding one or more images of said sequence of X-ray images, and generation of an averaged image from said set of images.

Abstract: An Angiographic X-ray imaging system provides enhanced image feature visualization. At least one repository includes data representing a sequence of X-ray images of a portion of patient anatomy acquired over a time interval and signal data representing electrical activity of the heart of the patient over the time interval. An image data processor determines for individual images of the sequence of X-ray images, characteristics of a portion of the signal data associated with a corresponding image. The characteristics comprise at least one of, (a) a peak to peak value of a portion of the signal data associated with a corresponding image and (b) an average value of a portion of the signal data associated with the corresponding image. The image data processor selects a set of images exclusive of particular images from the sequence of X-ray images in response to the determined characteristics and generates an averaged image from the set of images.