Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: A device for locating target points on a magnetic resonance image of the brain of a subject includes a trained neural network configured to receive as input a 3D MR image of the brain of a subject, and to output the location, on the image, of at least one determined brain target point. The neural network includes a plurality of processing stages. Each processing stage processes an image at a respective resolution, and the processing stage of lowest resolution outputs an estimate of the location of each target point. Each other processing stage is configured to receive, from a lower resolution processing stage, an estimate of the locations of the target points, crop the input image to a smaller region surrounding each estimated target point, determine an updated estimate of the location of each target point, and provide the updated estimation to the processing stage of the next higher resolution.

Abstract: A wood heating system comprises an electric power source, a first electrode assembly, a second electrode assembly, and a control system. The first electrode assembly is connected to the electric power source and is adapted to make electrical contact with a first end of a wood length to apply electric power to the wood length. The first electrode assembly comprises at least two electrode segments. The second electrode assembly is adapted to make electrical contact with a second end of the wood length. The control system is adapted to selectively connect/disconnect electric power flow between the electric power source and at least one electrode segment of the first electrode assembly.

Abstract: A gas delivery component of a CPAP system is configured to magnetically connect to a second gas delivery component of the CPAP system to deliver a pressurized flow of breathable gas to a patient's airways. The gas delivery component includes a lumen forming a first part of a gas flow path for the breathable gas. A connection end of the gas delivery component is configured to engage the second gas delivery component. In addition, a magnetic connection assembly is located at the connection end and includes a magnet positioned at least partially within the lumen. The magnetic connection assembly is configured to magnetically secure the gas delivery component to the second gas delivery component.

Abstract: A gas delivery component of a CPAP system is configured to magnetically connect to a second gas delivery component of the CPAP system to deliver a pressurized flow of breathable gas to a patient's airways. The gas delivery component includes a lumen forming a first part of a gas flow path for the breathable gas. A connection end of the gas delivery component is configured to engage the second gas delivery component. In addition, a magnetic connection assembly is located at the connection end and includes a magnet positioned at least partially within the lumen. The magnetic connection assembly is configured to magnetically secure the gas delivery component to the second gas delivery component.

Abstract: A patient interface assembly is configured to deliver a positively pressurized flow of breathable gas to a patient's airways. The patient interface assembly includes a patient interface configured to sealingly engage the patient's face and comprises a chamber configured to receive the pressurized flow of breathable gas. The patient interface assembly also includes headgear configured to support the patient interface on the patient's head and be tightened to one of a plurality of discrete tension settings. The headgear includes a tensioning element that is configured to contract in length to one of a plurality of discrete lengths when subjected to an electrical signal. Each discrete length of the tensioning element corresponds to a respective one of the plurality of discrete headgear tension settings.

Abstract: A patient interface assembly is configured to deliver pressurized gas to the patient's airways. The patient interface assembly includes a patient interface structure that is configured to sealingly engage the patient's face. The patient interface includes a receptacle. The patient interface assembly further includes headgear configured to support the patient interface structure on the patient's head. The headgear includes a clip that is receivable by the receptacle. The receptacle and the clip together form a multiple stage connection arrangement in which each of the multiple stages corresponds to an interlocked position of the clip in the receptacle. Each stage is associated with a corresponding range of headgear tension.

Abstract: A cushion for a patient interface includes two or more bladders arranged in concentric relation. Each of the bladders includes a face-contacting portion adapted to engage the patient's face, and each of the bladders is adapted to be pressurized independently from one another. At least one of the bladders is an active bladder that is pressurized to at least a sealing pressure to form a continuous seal with the patient's face in use.

Abstract: Among other things, the present disclosure provides technologies for efficient and effective identification of ETaGs, for example, from fungi genomes. In some embodiments, provided technologies are particularly useful for identifying mammalian targets of biosynthetic products of fungi. In some embodiments, provided technologies are particularly useful for identifying and/or prioritizing human targets for drug development. In some embodiments, provided technologies are particularly useful for developing modulators for human targets based on biosynthetic products of fungi.

Abstract: Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

Abstract: A wood heating system comprises an electric power source, a first electrode assembly, a second electrode assembly, and a control system. The first electrode assembly is connected to the electric power source and is adapted to make electrical contact with a first end of a wood length to apply electric power to the wood length. The first electrode assembly comprises at least two electrode segments. The second electrode assembly is adapted to make electrical contact with a second end of the wood length. The control system is adapted to selectively connect/disconnect electric power flow between the electric power source and at least one electrode segment of the first electrode assembly.

Abstract: Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

Abstract: Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

Abstract: A breathing apparatus includes components, including, but not limited to, a flow generator, a patient interface, and a delivery conduit. A connector for connecting components of the breathing apparatus includes a male connector, including a recess, extending from a first component, and a female connector, including a lever pivotally connected thereto, extending from a second component. A switch indicates a connection state of the connector. The switch includes a ring provided in an end of the first or second component and the ring includes a projection extending through an aperture in the end of the first or second component. The projection is movable between a first position and a second position to indicate the state of the connector.

Abstract: A breathing apparatus includes components, including, but not limited to, a flow generator, a patient interface, and a delivery conduit. A connector for connecting components of the breathing apparatus includes a male connector, including a recess, extending from a first component, and a female connector, including a lever pivotally connected thereto, extending from a second component. A switch indicates a connection state of the connector. The switch includes a ring provided in an end of the first or second component and the ring includes a projection extending through an aperture in the end of the first or second component. The projection is movable between a first position and a second position to indicate the state of the connector.

Abstract: A patient interface assembly is configured to deliver pressurized gas to the patient's airways. The patient interface assembly includes a patient interface structure that is configured to sealingly engage the patient's face. The patient interface includes a receptacle. The patient interface assembly further includes headgear configured to support the patient interface structure on the patient's head. The headgear includes a clip that is receivable by the receptacle. The receptacle and the clip together form a multiple stage connection arrangement in which each of the multiple stages corresponds to an interlocked position of the clip in the receptacle.

Abstract: Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

Abstract: Headgear for a patient interface includes at least one headgear strap and an indicator provided to the at least one headgear strap structured to indicate attainment of a desired adjustment setting of the headgear in response to headgear tension applied to the at least one headgear strap.