Abstract: A system for pipeline testing uses an electronics control module to monitor remote sensor data and compare the remote sensor data to control parameter input data that includes data indicating acceptable testing parameter ranges. In response to the comparison of the real time sensor data and the control parameter input data, the electronics control module generates various control signals used to control an automated fluid control system to regulate the pressure in the pipeline being tested and, if necessary, instigate an emergency shutdown of the test and to release all pressure from the section of pipe being tested. All test data is recorded, stored, and made available as needed/desired.

Abstract: The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

Abstract: The present invention addresses the need for better pharmaceutical agents for teating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.

Abstract: A clip or bracket releasably mountable to a rail having elongated perforations to retain one or more items in a stored position when not in use. In a simple embodiment, the clip is formed of a continuous length of metal or plastic rod having a pair of parallel legs for insertion through the mounting rail perforation, and a three-sided enclosure which, in cooperation with the surface of the mounting rail, form a four-sided enclosure for retaining the stored item. In a second, preferred embodiment, a bracket is formed with an integral, three-sided wall with one or more latching members affixed to one of the walls for releasably attaching the bracket to the mounting rail with portions of the latching member(s) extending through one of the perforations. In one form, a pair of three-sided retainers are connected to one another with latching member(s) mounted between adjacent walls of the two retainers.

Abstract: The present invention encompasses analogs of humanized antibody Hu007 that neutralize IL-1? activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.

Abstract: The present invention provides an insulin molecule that provides a protracted, even basal duration of action. The insulin molecule comprises a modification at the N-terminus of the A-chain, optionally a modification at the N-terminus of the B-chain, a modification at a B-chain lysine, and optionally a modification at the C-terminus of the A-chain. The present invention also provides a method of treating diabetes mellitus comprising administering the insulin molecule.