Patents by Inventor John Beamond Nicholas

John Beamond Nicholas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
    Publication number: 20220324814
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
    Type: Application
    Filed: April 12, 2022
    Publication date: October 13, 2022
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler, Kumaraswamy Emayan, Jingyuan Ma
  • Calpain modulators and therapeutic uses thereof
    Patent number: 11339130
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: May 24, 2022
    Assignee: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler, Kumaraswamy Emayan, Jingyuan Ma
  • Calpain modulators and therapeutic uses thereof
    Patent number: 11292801
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic ?-keto amide derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: April 5, 2022
    Assignee: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, Shendong Yuan, John Beamond Nicholas, Jingyuan Ma, Kumaraswamy Emayan, Marc Adler
  • CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
    Publication number: 20210347727
    Abstract: Small molecule calpain modulator compositions and pharmaceutical compositions can be prepared and used as therapeutic agents. Exemplary compositions include non-macrocyclic a-keto amide derivatives. The therarapeutic agents can be used for treating fibrotic disease or a resulting secondary disease state or condition. The small molecules can competitively bind with calpastatin and/or inhibit calpain through contact with CAPN1, CAPN2, and/or CAPN9 enzymes.
    Type: Application
    Filed: June 19, 2018
    Publication date: November 11, 2021
    Inventors: Brad Owen Buckman, Shendong Yuan, John Beamond Nicholas, Jingyuan Ma, Kumaraswamy Emayan, Marc Adler
  • Calpain modulators and therapeutic uses thereof
    Patent number: 10934261
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: March 2, 2021
    Assignee: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler, Kumaraswamy Emayan, Jingyuan Ma
  • Anti-fibrotic pyridinones
    Patent number: 10898474
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: January 26, 2021
    Assignee: INTERMUNE, INC.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert
  • Calpain modulators and therapeutic uses thereof
    Patent number: 10894776
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: January 19, 2021
    Assignee: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler, Kumaraswamy Emayan, Jingyuan Ma
  • CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
    Publication number: 20200392157
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic ?-keto amide derivatives and their use as therapeutic agents.
    Type: Application
    Filed: June 29, 2017
    Publication date: December 17, 2020
    Inventors: Brad Owen Buckman, Shendong Yuan, John Beamond Nicholas, Jingyuan Ma, Kumaraswamy Emayan, Marc Adler
  • CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF
    Publication number: 20200123114
    Abstract: Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
    Type: Application
    Filed: September 27, 2017
    Publication date: April 23, 2020
    Applicant: Blade Therapeutics, Inc.
    Inventors: Brad Owen BUCKMAN, John Beamond NICHOLAS, Shendong YUAN, Marc ADLER, Kumaraswamy EMAYAN, Jingyuan MA
  • Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
    Patent number: 10590084
    Abstract: The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: March 17, 2020
    Assignee: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler
  • Anti-fibrotic pyridinones
    Patent number: 10544161
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: January 28, 2020
    Assignee: INTERMUNE, INC.
    Inventors: Johnnie Y. Ramphal, Brad Owen Buckman, Kumaraswamy Emayan, John Beamond Nicholas, Scott D. Seiwert
  • Anti-Fibrotic Pyridinones
    Publication number: 20190321343
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 24, 2019
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert
  • Anti-fibrotic pyridinones
    Patent number: 10376497
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 13, 2019
    Assignee: INTERMUNE, INC.
    Inventors: Brad O. Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert
  • CYCLIC KETO-AMIDE COMPOUNDS AS CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20190194139
    Abstract: The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.
    Type: Application
    Filed: March 8, 2017
    Publication date: June 27, 2019
    Applicant: Blade Therapeutics, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Shendong Yuan, Marc Adler
  • ANTI-FIBROTIC PYRIDINONES
    Publication number: 20190144467
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 16, 2019
    Inventors: Johnnie Y. Ramphal, Brad Owen Buckman, Kumaraswamy Emayan, John Beamond Nicholas, Scott D. Seiwert
  • Anti-fibrotic pyridinones
    Patent number: 10233195
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: March 19, 2019
    Assignee: INTERMUNE, INC.
    Inventors: Johnnie Y. Ramphal, Brad Owen Buckman, Kumaraswamy Emayan, John Beamond Nicholas, Scott D. Seiwert
  • Anti-Fibrotic Pyridinones
    Publication number: 20180064692
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Application
    Filed: April 20, 2017
    Publication date: March 8, 2018
    Inventors: Brad O. Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert
  • Anti-fibrotic pyridinones
    Patent number: 9675593
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 13, 2017
    Assignee: INTERMUNE, Inc.
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert
  • ANTI-FIBROTIC PYRIDINONES
    Publication number: 20170121345
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Application
    Filed: March 31, 2015
    Publication date: May 4, 2017
    Inventors: Johnnie Y. Ramphal, Brad Owen Buckman, Kumaraswamy Emayan, John Beamond Nicholas, Scott D. Seiwert
  • ANTI-FIBROTIC PYRIDINONES
    Publication number: 20160263090
    Abstract: Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
    Type: Application
    Filed: May 23, 2016
    Publication date: September 15, 2016
    Inventors: Brad Owen Buckman, John Beamond Nicholas, Johnnie Y. Ramphal, Kumaraswamy Emayan, Scott D. Seiwert