Patents by Inventor John Bertin

John Bertin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20030113787
    Abstract: Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 19, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventor: John Bertin
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20030109428
    Abstract: Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-1l, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10 or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 2, 2001
    Publication date: June 12, 2003
    Inventor: John Bertin
  • Novel molecules of the PYRIN/NBS/LRR protein family and uses thereof
    Publication number: 20030027757
    Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-11, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted.
    Type: Application
    Filed: January 31, 2002
    Publication date: February 6, 2003
    Inventors: John Bertin, Weiye Wang, Maria Blatcher
  • Novel molecules of the pyrin/NBS/LRR protein family and uses thereof
    Publication number: 20030017983
    Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted.
    Type: Application
    Filed: April 17, 2002
    Publication date: January 23, 2003
    Inventors: John Bertin, Weiye Wang, Maria Blatcher
  • Novel molecules of the PYRIN domain protein family and uses thereof
    Publication number: 20020197660
    Abstract: Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-&kgr;B.
    Type: Application
    Filed: December 20, 2001
    Publication date: December 26, 2002
    Inventors: John Bertin, Gulam A. Manji
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020197693
    Abstract: Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, and anti-murine CARD-4L antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L gene has been introduced or disrupted. The invention further provides CARD-3 and CARD-4 target proteins that bind to CARD-3 or CARD-4 and allelic variants of human CARD-4.
    Type: Application
    Filed: April 9, 2002
    Publication date: December 26, 2002
    Applicant: Millennium Pharmaceuticals, Inc., a Delaware corporation
    Inventor: John Bertin
  • Novel molecules of the pyrin domain protein family and uses thereof
    Publication number: 20020187922
    Abstract: Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-&kgr;B.
    Type: Application
    Filed: April 22, 2002
    Publication date: December 12, 2002
    Inventors: John Bertin, Gulam A. Manji
  • Molecules of the card-related protein family and uses thereof
    Patent number: 6482933
    Abstract: Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, anti-CARD-5, and anti-CARD-6 antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: November 19, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: John Bertin
  • Molecules of the card-related protein family and uses thereof
    Patent number: 6469140
    Abstract: CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD,-4Z, and murine CARD-4L polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, and anti-murine CARD-4L antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, and murine CARD-4L gene has been introduced or disrupted. The invention further provides CARD-3 and CARD-4 target proteins that bind to CARD-3 or CARD-4 and allelic variants of human CARD-4.
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: October 22, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: John Bertin
  • Novel molecules of the NBS/LRR protein family and uses thereof
    Publication number: 20020150920
    Abstract: Novel NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 proteins, the invention further provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 fusion proteins, antigenic peptides and anti-NBS-2, anti-NBS-3, anti-PYRIN-12/NBS-4, and anti-NBS-5 antibodies. The invention also provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a NBS-2, NBS-3, PYRIN-12/NBS-4, or NBS-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: October 22, 2001
    Publication date: October 17, 2002
    Inventors: John Bertin, Weiye Wang, Maria Blatcher
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020150987
    Abstract: Novel CARD-3, CARD-4L and CARD-4S polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, CARD-3, CARD-4L and CARD-4S proteins, and the invention further provides isolated CARD-3, CARD-4L and CARD-4S fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S antibodies. The invention also provides CARD-3, CARD-4L and CARD-4S nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L or CARD-4S gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 25, 2002
    Publication date: October 17, 2002
    Applicant: Millennium Pharmaceuticals, Inc., a Delaware corporation
    Inventor: John Bertin
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020142979
    Abstract: Novel CARD-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to CARD-5 proteins, and the invention further provides CARD-5 fusion proteins, antigenic peptides and anti-CARD-5 antibodies. The invention also provides CARD-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: April 24, 2001
    Publication date: October 3, 2002
    Inventor: John Bertin
  • Novel molecules of the card related protein family and uses thereof
    Publication number: 20020128219
    Abstract: CARD-7 and CARD-8 polypeptides, proteins, and nucleic acid molecules are disclosed. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: August 15, 2001
    Publication date: September 12, 2002
    Inventors: John Bertin, Emad S. Alnemri
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020128198
    Abstract: Novel CARD-7 and CARD-8 polypeptides, proteins, and nucleic acid molecules are disclosed. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: November 27, 2001
    Publication date: September 12, 2002
    Inventor: John Bertin
  • Genes encoding caspase recruitment domain polypeptides
    Publication number: 20020123115
    Abstract: The invention relates to nucleic acid molecules encoding CARD-3, nucleic acid molecules encoding CARD-4, CARD-3 polypeptides, CARD-4 polypeptides, and uses thereof.
    Type: Application
    Filed: April 26, 2002
    Publication date: September 5, 2002
    Applicant: Millennium Pharmaceuticals, Inc. a Delaware corporation
    Inventor: John Bertin
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020086980
    Abstract: Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: December 1, 2000
    Publication date: July 4, 2002
    Inventor: John Bertin
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020081636
    Abstract: Novel CARD-14 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-14 proteins, the invention further provides CARD-14 fusion proteins, antigenic peptides and anti-CARD-14 antibodies. The invention also provides CARD-14 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-14 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: January 22, 2001
    Publication date: June 27, 2002
    Inventor: John Bertin
  • Caspase recruitment domain polypeptides
    Patent number: 6410689
    Abstract: The invention relates to nucleic acid molecules encoding CARD-3, nucleic acid molecules encoding CARD-4, CARD-3 polypeptides, CARD-4 polypeptides, and uses thereof.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: June 25, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: John Bertin
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020061833
    Abstract: The invention relates to CARD-3, a mediator of apoptosis. CARD-3 contains a CARD domain and a serine/threonine kinase domain. CARD-3 nucleic acids and polypeptides are useful in mediating apoptosis and in the identification of compounds which modulate apoptosis.
    Type: Application
    Filed: December 26, 2000
    Publication date: May 23, 2002
    Inventors: John Bertin, Moses V. Chao
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020061845
    Abstract: Novel CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 proteins, and the invention further provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 fusion proteins, antigenic peptides and anti-CARD-3, anti-CARD-4L and anti-CARD-4S, anti-CARD-4Y, anti-CARD-4Z, anti-CARD-5, and anti-CARD-6 antibodies. The invention also provides CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-3, CARD-4L, CARD-4S, CARD-4Y, CARD-4Z, CARD-5, and CARD-6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: December 1, 2000
    Publication date: May 23, 2002
    Inventor: John Bertin