Abstract: The invention concerns a compound of formula (I) wherein for example R1 is of the formula —NHC(═O)Ra wherein Ra is hydrogen, or (1-4C)alkyl; R2 and R3 are independently hydrogen or fluoro, R4 is hydrogen, (1-4C)alkyl, halo or trifluoromethyl; R5 and R6 are, for example, independently hydrogen, (1-4C)alkyl, an acetylene of the formula -≡-H or -≡-(1-4C)alkyl, or a group of formula (IA) wherein, for example, Z is hydrogen or (1-4C)alkyl; X and Y are (1-4C)alkyl, halo, cyano, phenyl or heteroaryl; provided that X, Y and Z do not define a (2-4C)alkenyl group and provided that at least one of R5 and R6 is a group of formula (IA) or an acetylene of the formula -≡-H or -≡-(1-4C)alkyl; and pharmaceutically acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.

Abstract: The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4alkyl, nitro, hydroxy, carboxy, C1-4alkoxy, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl, di-C1-4-alkylaminosulphonyl, carbamoyl, C1-4alkylcarbamoyl, di-C1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4alkylamino, di-C 14alkylamino, C1-4alkanoylamino, C1-4alkanoyl(H-C1-4alkyl)amino, C1-4alkanesulphonamido and C1-4alkylS(O)n— wherein n is zero, one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to —NR3—.

Abstract: The invention concerns a compound of formula (I) wherein: R.sup.1 is of the formula --NHC(.dbd.O)(1-4C)alkyl, --NHS(O).sub.n (1-4C)alkyl wherein n is 0, 1 or 2 or R.sup.1 is hydroxy; R.sup.2 and R.sup.3 are independently hydrogen or fluoro; R.sup.4 is hydrogen, methyl, ethyl or oxo; R.sup.5 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or of the formula R.sup.6 (CH.sub.2).sub.m -- wherein either m is 1-4 and R.sup.6 is, for example, trifluoromethyl, difluoromethyl, fluoromethyl, (1-4C)alkoxy, (1-4C)alkyl S(O).sub.p -- wherein p is 0, 1 or 2, (1-6C)alkanoyloxy, di-(N-(1-4C)alkyl)amino, N-((1-4C)alkyl)(1-4C)alkanoylamino, cyano, carboxy, (1-4C)alkoxycarbonyl, carbamoyl, di-(N-(1-4C)alkyl)carbamoyl, N-((1-4C)alkyl)(1-4C)alkanesulphonamido, N.sup.1 -((1-4C)alkyl)-di-(N.sup.3 -(1-4C)alkyl)ureido, or of the formula --OC(.dbd.O)NR.sup.7 (R.sup.8) or --N(R.sup.9)SO.sub.2 NR.sup.7 (R.sup.8) wherein R.sup.7 and R.sup.8 are independently hydrogen or (1-4C)alkyl and R.sup.9 is (1-4C)alkyl; or m is 2-4 and R.sup.

Abstract: The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 is hydrogen or C.sub.1-4 alkyl;R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4 alkyl, nitro, hydroxy, carboxy, C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, C.sub.1-4 alkylaminosulphonyl, di-C.sub.1-4 -alkylaminosulphonyl, carbamoyl, C.sub.1-4 alkylcarbamoyl, di-C.sub.1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkanoyl(N--C.sub.1-4 alkyl)amino, C.sub.1-4 alkanesulphonamido and C.sub.1-4 alkylS(O).sub.n -- wherein n is zero, one or two:with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to --NR.sup.3 --.

Abstract: The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 is hydrogen or C.sub.1-4 alkyl;R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4 alkyl, nitro, hydroxy, carboxy, C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, C.sub.1-4 alkylaminosulphonyl, di-C.sub.1-4 -alkylaminosulphonyl, carbamoyl, C.sub.1-4 alkylcarbamoyl, di-C.sub.1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkanoyl(N-C.sub.1-4 alkyl)amino, C.sub.1-4 alkanesulphonamido and C.sub.1-4 alkylS(O)n- wherein n is zero, one or two:with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the link to --NR.sup.3 --.

Abstract: Inhibitors of esterase-producing micro-organisms, primarily for use in dermatology and cosmetics and with particular application to personal deodorants and to anti-fungal agents and other preparations for the treatment of acne, dandruff and tinea pedis. The active ingredient of the inhibitor comprises an aromatic acid ester of a phenol or of an aromatic alcohol, the phenol or aromatic alcohol being sufficiently water-soluble to impart an anti-microbial action and the aromatic acid being sufficiently water-soluble to impart an anti-microbial action and/or to lower the pH of liquid body-secretions to a level which at least inhibits the growth of micro-organisms in the liquid body-secretions.

Abstract: A mechanism for obtaining a strip record of an environmental measurement. The mechanism is used in conjunction with a clock drive which advances a recording strip and with a stylus which marks an indication of the environmental status on the recording strip. The mechanism includes a housing having an exterior and interior portion which encloses the marking stylus. The recording strip is supported by a holder to permit marking by the stylus. An element is connected to the recording strip and fixed relative to the housing for permitting marking of the recording strip by the stylus. The element is removed from the housing by movement away from the marking stylus.