Patents by Inventor John Bielicki

John Bielicki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cysteine-containing peptides having antioxidant properties
    Publication number: 20060286632
    Abstract: Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related proteins, imparts a unique antioxidant activity to these peptides which inhibits lipid peroxidation and protects phospholipids from water-soluble free radical initiators. These peptides can be used as therapeutic agents to combat cardiovascular disease, ischemia, bone disease and other inflammatory related diseases.
    Type: Application
    Filed: July 7, 2005
    Publication date: December 21, 2006
    Applicant: The Regents of the University of California
    Inventor: John Bielicki
  • Cysteine-containing peptides having antioxidant properties
    Publication number: 20060263848
    Abstract: Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related proteins, imparts a unique antioxidant activity to these peptides which inhibits lipid peroxidation and protects phospholipids from water-soluble free radical initiators. These peptides can be used as therapeutic agents to combat cardiovascular disease, ischemia, bone disease and other inflammatory related diseases.
    Type: Application
    Filed: July 7, 2005
    Publication date: November 23, 2006
    Applicant: The Regents of the University of California
    Inventor: John Bielicki
  • Helical synthetic peptides that stimulate cellular cholesterol efflux
    Publication number: 20050202532
    Abstract: The present invention provides peptides comprising at least one amphipathic alpha helix and having an cholesterol mediating activity and a ABCA stabilization activity. The invention further provides methods of using such peptides.
    Type: Application
    Filed: December 15, 2004
    Publication date: September 15, 2005
    Applicant: The Regents of the University of California
    Inventors: John Bielicki, Pradeep Natarajan