Abstract: The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.

Abstract: The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.

Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

Abstract: The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.

Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

Abstract: Apparatus and methods for coating an article on a flat line, powder coating system comprises a powder coating booth with a reduced inlet opening for articles to be coated and an enlarged outlet opening for coated articles. Powder spray guns of the tribo-electric type, or having internal charging electrodes, are arranged in rows with parallel tube spray heads and are disposed at a shallow angle with respect to the conveyor to spray powder onto the articles generally in the direction of conveyor movement. Baffle plates are installed under the spray guns so that any powder which collects on the spray guns does not fall on the articles being coated. Oversprayed powder is collected from a part of the booth intermediate the spray guns and the enlarged outlet opening. Preferably, the thickness of powder coating on the articles in the precured condition is measured and the system is controlled so that the coating thickness is uniform and of the desired thickness.

Abstract: A method and apparatus for forming a head, having a controlled predetermined shape on an end of an elongate member, such as a wire, which is formed into a fastener, where an end portion of the wire is secured in a predetermined position and axially compressed so as to expand a predetermined amount of wire material radially outwardly and thereby form the head on the wire, and where material flow is directed during axial compression so as to provide the controlled predetermined shape of the head.

Abstract: A method and apparatus for forming a head, having a controlled predetermined shape, on an end of an elongate member, such as a wire, which is formed into a fastener, where an end portion of the wire is secured in a predetermined position and axially compressed so as to expand a predetermined amount of wire material radially outwardly and thereby form the head on the wire, and where material flow is directed during axial compression so as to provide the controlled predetermined shape of the head.

Abstract: Nails having radially offset, circular heads are manufactured from a malleable wire. The wire is clamped so that a leading portion extends axially from a clamping mechanism. The extending portion is bent at an acute angle relative to a clamping axis. The extending portion is cut so as to form a pointed end thereon and so as to leave a bent stub extending at such an angle. Such a nail head is formed from the stub, which is pressed by a punch into a cavity defined by the clamping mechanism, and which is deformed when pressed thereinto. The cavity has a fully circular, offset margin. The punch has a face covering the cavity. Once released, the wire is fed axially until a leading portion extends as before. These operations are repeated to form a similar nail in each repetition. A novel apparatus for carrying out these operations is disclosed.

Abstract: A wire nail with a head having a circumferential edge conforming to a complete circle and disposed in a radially offset relationship with respect to a shank. A flat surface on the shank provides a datum indicating where the shank is located. A flat surface on the shank provides a datum for orienting such nail and similar nails. In some embodiments, a tangent plane defined by means of a lower or underside portion of the head is oriented at an acute angle (75.degree. to 85.degree.) relative to the shank. In a strip of such (collated) nails, the flat surfaces defined upon the shanks define an open channel, which coacts with a rib integrally provided upon one wall of a nail-feeding mechanism. In a nail-making machine, two gripping members defining an annular recess and a punch are used to form such a nail from a wire of a malleable metal.

Abstract: A wire nail with a head having a circumferential edge conforming to a complete circle and disposed in a radially offset relationship with respect to a shank. A flat surface on defined upon the shank provides a datum indicating where the shank is located. A flat surface on the shank provides a datum for orienting such nail and similar nails. In some embodiments, a tangent plane defined by means of a lower or underside portion of the head is oriented at an acute angle (75.degree. to 85.degree.) relative to the shank. In a strip of such (collated) nails, the flat surfaces defined upon the shanks define an open channel, which coacts with a rib integrally provided upon one wall of a nail-feeding mechanism. In a nail-making machine, two gripping members defining an annular recess and a punch are used to form such a nail from a wire of a malleable metal.