Patents by Inventor John Bixby

John Bixby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250145586
    Abstract: Provided herein are compounds useful as kinase inhibitors, e.g., ROCK, S6K, and/or PKC inhibitors, and useful in neurite growth and axonal growth.
    Type: Application
    Filed: March 11, 2024
    Publication date: May 8, 2025
    Inventors: Hassan Al-Ali, Vance Lemmon, John Bixby
  • Patent number: 11981660
    Abstract: Provided herein are compounds useful in treating a central nervous system disorder associated with neuronal and/or axonal damage, methods for their preparation, and related pharmaceutical compositions. For example provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: May 14, 2024
    Assignees: UNIVERSITY OF MIAMI, Torrey Pines Institute for Molecular Studies
    Inventors: Vance Lemmon, Hassan Al-Ali, John Bixby, Marc Giulianotti
  • Patent number: 11926613
    Abstract: Provided herein are compounds of the general Formula (I) which act as kinase inhibitors, e.g. ROCK, S6K, and/or PKC inhibitors, and are useful in neurite growth and axonal growth.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: March 12, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Hassan Al-Ali, Vance Lemmon, John Bixby
  • Publication number: 20210163444
    Abstract: Provided herein are compounds of the general Formula (I) which act as kinase inhibitors, e.g. ROCK, S6K, and/or PKC inhibitors, and are useful in neurite growth and axonal growth.
    Type: Application
    Filed: October 31, 2018
    Publication date: June 3, 2021
    Inventors: Hassan Al-Ali, Vance Lemmon, John Bixby
  • Publication number: 20210017162
    Abstract: Provided herein are compounds useful in treating a central nervous system disorder associated with neuronal and/or axonal damage, methods for their preparation, and related pharmaceutical compositions. For example provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same.
    Type: Application
    Filed: March 21, 2019
    Publication date: January 21, 2021
    Inventors: Vance Lemmon, Hassan Al-Ali, John Bixby, Marc Giulianotti
  • Publication number: 20170147743
    Abstract: A computing system automatically analyzes various drug or other compound targets using biologic activity data for cellular proteins, and develops a target/anti-target matrix identifying pharmacologically responsive targets intended for drug engagement, and pharmacologically responsive anti-targets intended for avoidance of drug engagement. The system separates compounds into subsets based on biological threshold data and groups proteins through pharmacological similarity. The system ranks protein groupings in generating the matrix and uses the rankings to recommend compounds and compound groupings for testing to treat a pathology. The system compares new compounds against the matrix to recommend new compounds for testing.
    Type: Application
    Filed: November 23, 2016
    Publication date: May 25, 2017
    Inventors: John Bixby, Vance Lemmon, Hassan Al-Ali
  • Patent number: 8609617
    Abstract: This invention relates, to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 9,12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e.g., KLF 6 and/or 7).
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: December 17, 2013
    Assignee: University of Miami
    Inventors: Jeffrey L. Goldberg, Vance P. Lemmon, John Bixby, Darcie Moore, Murray Blackmore
  • Publication number: 20120225084
    Abstract: This invention relates, e.g., to a method for promoting CNS axon regeneration, comprising (1) inhibiting the expression or activity in a neuron of one or more of the members of the Krüppel-like transcription factor (KLF) family that suppress axon growth (e.g., KLF 1, 2, 3, 4, 5, 9, 12, 13, 14, 15 and/or 16), and/or (2) stimulating the expression or activity in a neuron of one or more of the members of the KLF family that promote axon growth (e.g., KLF 6 and/or 7).
    Type: Application
    Filed: September 7, 2010
    Publication date: September 6, 2012
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Jeffrey L. Goldberg, Vance P. Lemmon, John Bixby, Darcie Moore, Murray Blackmore
  • Publication number: 20060113712
    Abstract: A method for promoting adhesion of a “skin” forming on the surface of a paint stored in a plastic paint container (10) to walls of the container first includes molding a can (12), plug (14), and ring (16) comprising the container to have their interior surfaces as textured, non-smooth surfaces. Next, the interior surfaces of the can, plug, and ring are subjected to an energy treatment after these parts are removed from their molds. This is done to produce an energy change in these surfaces. Third, an adhesion promoting material is applied to the energy treated interior surfaces of the container. This adhesion promoting material, which is preferably a chlorinated polyolefin, promotes adhesion of the skin to these interior surfaces as the skin forms. The material is applied within a predetermined period after the parts are energy treated.
    Type: Application
    Filed: November 29, 2004
    Publication date: June 1, 2006
    Inventors: Francis Azzarello, John Bixby, Timothy Moczulewski