Abstract: The present invention relates to binding agents that specifically bind human MET, binding agents that specifically bind one or more components of the WNT pathway, bispecific agents that bind both human MET and one or more components of the WNT pathway, and methods of using the agents for treating diseases such as cancer.

Abstract: The present invention relates to binding agents that specifically bind human MET, binding agents that specifically bind one or more components of the WNT pathway, bispecific agents that bind both human MET and one or more components of the WNT pathway, and methods of using the agents for treating diseases such as cancer.

Abstract: Apparatus to produce a spatially and temporally uniform heat source is described and this is used to visualize latent fingerprints deposited onto thermal paper by raising the temperature of the paper. Results show an improvement over previous techniques, particularly when fingerprint deposits are aged or the developed fingerprints faint; visualization being enhanced by the use of an LED light source. An investigation of the components in fingerprint sweat likely to affect the solubility and hence colour change of the dye present in the thermal paper has shown that polar protic solvents able to donate a proton are favoured and a polar amino acid found commonly in eccrine fingerprint sweat (lysine) has been shown able to produce the desired colour change. Aged fingerprint deposits on thermal paper from a variety of sources up to four years old have been visualized with this technique.

Abstract: The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

Abstract: The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

Abstract: The present invention relates to binding agents that specifically bind human MET, binding agents that specifically bind one or more components of the WNT pathway, bispecific agents that bind both human MET and one or more components of the WNT pathway, and methods of using the agents for treating diseases such as cancer.

Abstract: The invention relates to an apparatus for and a method of detecting latent fingerprints on a previously heated substrate, such as a bullet casing following discharge of a bullet. By applying a potential difference across the substrate, and contacting the substrate with detection means, such as graphite coated beads, arranged to selectively attract to or repel from the area of a latent fingerprint on the surface, a latent fingerprint may be recovered.

Abstract: A method of and apparatus (2) for locating and detecting a fingerprint deposited on a surface (10), the method comprising setting up an electric field such that a differential charge density is produced coincident with the location of a fingerprint deposited on the surface. By deploying a conductive powder or other detection element selectively attractable to the surface (10) coincident with the differential charge density in the region of the fingerprint deposit a fingerprint deposited on the surface (10) is located and detected.

Abstract: The invention relates to an apparatus for and a method of detecting latent fingerprints on a previously heated substrate, such as a bullet casing following discharge of a bullet. By applying a potential difference across the substrate, and contacting the substrate with detection means, such as graphite coated beads, arranged to selectively attract to or repel from the area of a latent fingerprint on the surface, a latent fingerprint may be recovered.

Abstract: A method of and apparatus (2) for locating and detecting a fingerprint deposited on a surface (10), the method comprising setting up an electric field such that a differential charge density is produced coincident with the location of a fingerprint deposited on the surface. By deploying a conductive powder or other detection element selectively attractable to the surface (10) coincident with the differential charge density in the region of the fingerprint deposit a fingerprint deposited on the surface (10) is located and detected.

Abstract: A receptacle for a fastener which is inserted into a receptacle receiving member. The receptacle is insertable and rotatable in a hole in the receptacle receiving member and includes at least one arm extending from a fastener receiving member. The arm is arranged to engage with a first side of the receptacle receiving member on insertion of the fastener receiving member into the receptacle receiving member.

Abstract: An adaptive cruise control system includes a forward-looking sensor generating a range signal corresponding to a distance between the host vehicle and a target vehicle. The forward-looking sensor also generates a range rate signal corresponding to a rate that the distance between the host vehicle and the target vehicle is changing. A controller is electrically coupled to the forward-looking sensor. The controller maintains a preset headway distance between the host vehicle and the target vehicle by adjusting the host vehicle velocity in response to the range signal and the range rate signal. The host vehicle may come to a full stop when the target vehicle is acquired below a predetermined velocity. If the target vehicle is acquired above the predetermined velocity, then a warning is given when braking is required.

Abstract: A continuous process for making a thermoplastic article comprises extruding a sheet of thermoplastic and contacting the sheet with a mold surface while the sheet is in a substantially non-oriented state. The mold surface is selectively heated and/or cooled during thermoforming to maintain the sheet in a molten or thermoformable state. A stripper plate adjacent to the mold surface is maintained at different temperature for inducing a predetermined degree of crystallinity to the sheet, for increasing web stiffness and improving web alignment, and optionally for assisting in the separation of the articles from the mold. A continuous apparatus for making thermoformed articles has co-extruders for extruding at least two distinct layers, which can have dissimilar properties (e.g., polar and non-polar), and a temperature controlled molding surface. Preferred thermoplastic compositions of the present invention have improved toughness and retained intrinsic viscosity.

Abstract: Thermoplastic compositions comprising a bulk polymer, an additive, and a compatibilizer/emulsifier/surfactant (CES) are described. The bulk polymer comprises an alkylene terephthalate or naphthalate polyester such as polyethylene terephthalate. The additive comprises an amorphous or substantially amorphous co-polymer of ethylene and a co-monomer that forms polar portions, such as methacrylate, butylacrylate, ethyl acrylate, or ethylhexyl methacrylate. The CES comprises a co-polymer or ter-polymer of ethylene and a glycidyl acrylate or maleic anhydride, and optionally an acrylate such as methacrylate, ethylacrylate, propylacrylate, butylacrylate, ethylhexylacrylate, or mixtures thereof. The thermoplastic compositions of the present invention exhibit improved molding properties, high dimensional stability, high temperature resistance, and are particularly useful in food-grade applications such as dual-ovenable containers.

Abstract: A method and apparatus for use in creating a magnetic declination profile for a borehole. The method includes the steps of making a magnetic directional measurement at a longitudinal location in the borehole and at a magnetic measurement orientation, making a reference directional measurement at a reference measurement orientation, wherein there is a known orientation relationship between the magnetic measurement orientation and the reference measurement orientation, and obtaining a value of magnetic declination at the longitudinal location in the borehole using the magnetic directional measurement, the reference directional measurement and the orientation relationship.

Abstract: Thermoplastic compositions comprising a bulk polymer, an additive, and a compatibilizer/emulsifier/surfactant (CES) are described. The bulk polymer comprises an alkylene terephthalate or naphthalate polyester such as polyethylene terephthalate. The additive comprises an amorphous or substantially amorphous co-polymer of ethylene and a co-monomer that forms polar portions, such as methylacrylate, butylacrylate, ethylacrylate, or ethylhexyl methacrylate. The CES comprises a co-polymer or ter-polymer of ethylene and a glycidyl acrylate or maleic anhydride, and optionally an acrylate such as methylacrylate, ethylacrylate, propylacrylate, butylacrylate, ethylhexyl acrylate, or mixtures thereof. The thermoplastic compositions of the present invention exhibit improved molding properties, high dimensional stability, high temperature resistance, and are particularly useful in food-grade applications such as dual-ovenable containers.

Abstract: Thermoplastic compositions comprising a bulk polymer, an additive, and a compatibilizer/emulsifier/surfactant (CES) are described. The bulk polymer comprises an alkylene terephthalate or naphthalate polyester such as polyethylene terephthalate. The additive comprises an amorphous or substantially amorphous co-polymer of ethylene and a co-monomer that forms polar portions, such as methylacrylate, butylacrylate, ethylacrylate, or ethylhexyl methacrylate. The CES comprises a co-polymer or terpolymer of ethylene and a glycidyl acrylate or maleic anhydride, and optionally an acrylate such as methylacrylate, ethylacrylate, propylacrylate, butylacrylate, ethylhexyl acrylate, or mixtures thereof. The thermoplastic compositions of the present invention exhibit improved molding properties, high dimensional stability, high temperature resistance, and are particularly useful in food-grade applications such as dual-ovenable containers.

Abstract: An apparatus for thermoforming a thermoplastic article comprises an extrusion die for extruding a sheet of thermoplastic and a rotating wheel having at least one mold member. The mold member includes a male mold or forming cavity for receiving at least a portion of a substantially non-oriented (i.e., non-tensioned) thermoplastic sheet. The mold member is selectively heated and/or cooled during thermoforming to maintain the sheet in a molten or thermoformable state. The mold member also comprises a stripper plate maintained at a predetermined temperature or temperature distribution for inducing a predetermined degree of crystallinity to the sheet. The stripper plate enables the articles to be separated from the mold without distortion. In one embodiment, the thermoformed article has at least two and preferably at least three distinct regions of thermally-induced crystallinity.

Abstract: Thermoplastic compositions comprising a bulk polymer, an additive, and a compatibilizer/emulsifier/surfactant (CES) are described. The bulk polymer comprises an alkylene terephthalate or naphthalate polyester such as polyethylene terephthalate. The additive comprises an amorphous or substantially amorphous co-polymer of ethylene and a co-monomer that forms polar portions, such as methacrylate, butylacrylate, ethyl acrylate, or ethylhexyl methacrylate. The CES comprises a co-polymer or ter-polymer of ethylene and a glycidyl acrylate or maleic anhydride, and optionally an acrylate such as methacrylate, ethylacrylate, propylacrylate, butylacrylate, ethylhexylacrylate, or mixtures thereof. The thermoplastic compositions of the present invention exhibit improved molding properties, high dimensional stability, high temperature resistance, and are particularly useful in food-grade applications such as dual-ovenable containers.

Abstract: An ultrasonic system for grading meat transmits an ultrasonic signal into the meat and detects the resulting back-scattered signal. The envelope of the back-scattered signal is determined. A decaying exponential curve having the form y=exp(−Dt) is fitted to the envelope, where D is the attenuation factor for the curve and t is time. A grade of the meat is then determined as a function of the attenuation factor. It may be possible to improve the accuracy of this approach by measuring the total back-scattered energy from the back-signal and generating a grade for the meat based on a polynomial function of both the attenuation factor and the total back-scattered energy. Optionally, accuracy may be further enhanced by removing any anomalies in the back-scattered signal resulting from fat deposits in the meat before calculating the attenuation factor.