Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

Abstract: A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

Abstract: An electron emitter device is provided comprising a cathode comprising a conductive transition metal perovskite oxide comprising mobile conducting electrons exhibiting a conductivity of at least 10?6 ??1-cm?1 at room temperature, the transition metal perovskite oxide having a surface from which the mobile electrons are induced to emit upon receiving sufficient energy from an energy source; and an anode electrically coupled to the cathode and positioned to define an interelectrode conductive region between the anode and the cathode, onto which anode the emitted electrons are collected. The transition metal perovskite oxide may have formula Sr1-xBaxVO3. Related methods and devices based on the electron emitter device are also provided.

Abstract: An electron emitter device is provided comprising a cathode comprising a conductive transition metal perovskite oxide comprising mobile conducting electrons exhibiting a conductivity of at least 10?6 ??1-cm?1 at room temperature, the transition metal perovskite oxide having a surface from which the mobile electrons are induced to emit upon receiving sufficient energy from an energy source; and an anode electrically coupled to the cathode and positioned to define an interelectrode conductive region between the anode and the cathode, onto which anode the emitted electrons are collected. The transition metal perovskite oxide may have formula Sr1-xBaxVO3. Related methods and devices based on the electron emitter device are also provided.

Abstract: A tunable phase shifter is provided that includes a spatial phase shift element and a conducting sheet. The spatial phase shift element includes a dielectric substrate and a conductive antenna element mounted on the dielectric substrate. The conducting sheet is mounted a distance from the spatial phase shift element and configured to reflect an electromagnetic wave through the spatial phase shift element. The conductive antenna element is configured to radiate a second electromagnetic wave in response to receipt of the reflected electromagnetic wave. The distance between the conducting sheet and the spatial phase shift element can be changed to adjust a phase shift of the reflected electromagnetic wave.

Abstract: A tunable phase shifter is provided that includes a spatial phase shift element and a conducting sheet. The spatial phase shift element includes a dielectric substrate and a conductive antenna element mounted on the dielectric substrate. The conducting sheet is mounted a distance from the spatial phase shift element and configured to reflect an electromagnetic wave through the spatial phase shift element. The conductive antenna element is configured to radiate a second electromagnetic wave in response to receipt of the reflected electromagnetic wave. The distance between the conducting sheet and the spatial phase shift element can be changed to adjust a phase shift of the reflected electromagnetic wave.