Abstract: An antimicrobial nonwoven wet wipe includes i) a fibrous nonwoven substrate bonded with a crosslinkable VAE dispersion stabilized with one or more cationic vinyl alcohol-N-vinyl amine copolymer protective colloids, and ii) an aqueous lotion containing a cationic disinfectants absorbed in the nonwoven substrate. No anionic surfactants are present. The antimicrobial nonwoven wet wipes are produced by a) applying an aqueous composition including a crosslinkable VAE dispersion stabilized with one or more cationic vinyl alcohol-N-vinyl amine copolymers to a nonwoven substrate; b) drying; and c) applying an aqueous composition to the product of step b). At least one of the first and second aqueous com-positions includes a cationic disinfectant.

Abstract: A multi-level voltage regulator system/method providing discrete regulation of a DC-DC intermediate bus converter (IBC) output voltage (Vout) is disclosed. The disclosed system/method allows IBC Vout to be regulated in discrete steps during periods where IBC input voltage (Vin) falls below nominal operating values. Rather than shutting down or degrading IBC Vout in an unpredictable non-linear fashion based on IBC input/loading, IBC Vout is regulated in fixed discrete steps, allowing IBC-connected point-of-load (POL) converters to obtain stable power input that is well-defined over IBC Vin. IBC operating parameters may define multi-dimensional operational state spaces of IBC Vout regulation that ensure optimum power flow to attached POLs while maintaining operational stability within the IBC regulator. Instabilities in IBC/POL performance across variations in IBC Vin, load transients, POL loading, and environmental variables may be prevented using Vin voltage step hysteresis.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: A multi-level voltage regulator system/method providing discrete regulation of a DC-DC intermediate bus converter (IBC) output voltage (Vout) is disclosed. The disclosed system/method allows IBC Vout to be regulated in discrete steps during periods where IBC input voltage (Vin) falls below nominal operating values. Rather than shutting down or degrading IBC Vout in an unpredictable non-linear fashion based on IBC input/loading, IBC Vout is regulated in fixed discrete steps, allowing IBC-connected point-of-load (POL) converters to obtain stable power input that is well-defined over IBC Vin. IBC operating parameters may define multi-dimensional operational state spaces of IBC Vout regulation that ensure optimum power flow to attached POLs while maintaining operational stability within the IBC regulator. Instabilities in IBC /POL performance across variations in IBC Vin, load transients, POL loading, and environmental variables may be prevented using Vin voltage step hysteresis.

Abstract: A multi-level voltage regulator system/method providing discrete regulation of a DC-DC intermediate bus converter (IBC) output voltage (Vout) is disclosed. The disclosed system/method allows IBC Vout to be regulated in discrete steps during periods where IBC input voltage (Vin) falls below nominal operating values. Rather than shutting down or degrading IBC Vout in an unpredictable non-linear fashion based on IBC input/loading, IBC Vout is regulated in fixed discrete steps, allowing IBC-connected point-of-load (POL) converters to obtain stable power input that is well-defined over IBC Vin. IBC operating parameters may define multi-dimensional operational state spaces of IBC Vout regulation that ensure optimum power flow to attached POLs while maintaining operational stability within the IBC regulator. Instabilities in IBC/POL performance across variations in IBC Vin, load transients, POL loading, and environmental variables may be prevented using Vin voltage step hysteresis.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: Provided herein are Pyrrolopyrimidine Compounds having the following structure: wherein R1, R2, R3, and L are as defined herein, compositions comprising an effective amount of a Pyrrolopyrimidine Compound, and methods for treating or preventing breast cancer, more particularly triple negative breast cancer, comprising administering an effective amount of such Pyrrolopyrimidine Compounds to a subject in need thereof.

Abstract: The present invention provides a DC-DC power converter that comprises two or more Printed Wiring Boards (PWB) mounted parallel to one another and without encapsulation. Electronic components can be mounted on both sides of each board. The open design and parallel orientation of the PWBs allow airflow over components mounted on the PWBs. The PWBs are preferable made of FR-4 with copper foils, with one thicker board being comprised of more copper layers and the other boards comprised of less copper layers. In the preferred embodiment, the power processing elements are housed in the thicker PWB, while the thinner boards house the control circuitry.

Abstract: A multi-level voltage regulator system/method providing discrete regulation of a DC-DC intermediate bus converter (IBC) output voltage (Vout) is disclosed. The disclosed system/method allows IBC Vout to be regulated in discrete steps during periods where IBC input voltage (Vin) falls below nominal operating values. Rather than shutting down or degrading IBC Vout in an unpredictable non-linear fashion based on IBC input/loading, IBC Vout is regulated in fixed discrete steps, allowing IBC-connected point-of-load (POL) converters to obtain stable power input that is well-defined over IBC Vin. IBC operating parameters may define multi-dimensional operational state spaces of IBC Vout regulation that ensure optimum power flow to attached POLs while maintaining operational stability within the IBC regulator. Instabilities in IBC/POL performance across variations in IBC Vin, load transients, POL loading, and environmental variables may be prevented using Vin voltage step hysteresis.

Abstract: The present invention relates to a combination therapy of 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N?-(2,2,3,3,3-pentafluoro-propyl)-malonamide, or a pharmaceutically-acceptable salt thereof, and bevacizumab for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example a brain tumor.

Abstract: The present invention provides a DC-DC power converter that comprises two or more Printed Wiring Boards (PWB) mounted parallel to one another and without encapsulation. Electronic components can be mounted on both sides of each board. The open design and parallel orientation of the PWBs allow airflow over components mounted on the PWBs. The PWBs are preferable made of FR-4 with copper foils, with one thicker board being comprised of more copper layers and the other boards comprised of less copper layers. In the preferred embodiment, the power processing elements are housed in the thicker PWB, while the thinner boards house the control circuitry.

Abstract: A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The added ternary element improves the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same and strut pattern coated with a thin layer of gold. The nitinol stent has improved radioplacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.

Abstract: A stent and a delivery system for implanting the stent in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element in order to minimize the stress hysteresis of the superelastic material. The stress hysteresis is defined by the difference between the loading plateau stress and the unloading plateau stress of the superelastic material. The resulting delivery system has a small profile and includes a sheath covering the stent that has a thin wall. A guide wire core can also be made from the small stress hysteresis superelastic material.

Abstract: An elongated core member and an expandable frame for an embolic filtering device used to capture embolic debris in a body lumen. The expandable frame also includes a filtering element. A nickel-titanium alloy is used to form the frame, the elongated core member, or both the frame and the elongated core member. The nickel-titanium alloy includes at least one ternary element, such as iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium, so that the frame and/or elongated core member is also radiopaque.