Patents by Inventor John Bradley

John Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250051790
    Abstract: The present disclosure relates to compositions and methods for improving site-directed integration frequency in the genome of plant cells.
    Type: Application
    Filed: October 21, 2024
    Publication date: February 13, 2025
    Applicant: Monsanto Technology LLC
    Inventors: John BRADLEY, Larry A. GILBERTSON, Ervin NAGY, Christine SHYU, Peizhen YANG, Xudong YE
  • Publication number: 20240424022
    Abstract: The present disclosure relates, inter alia, to perturbagens and methods, including ex vivo methods, for directing a change in the cell state of T cells, e.g., naïve T cells, effector T cells and exhausted T cells. The present disclosure also relates to methods for mitigating or preventing T cell exhaustion, including contacting cells with a perturbagen ex vivo. Further, the present disclosure relates to methods for treating diseases or disorders characterized by, e.g., production of exhausted T cells, production of abnormal number of exhausted T cells, or production of high number of T cells.
    Type: Application
    Filed: September 1, 2022
    Publication date: December 26, 2024
    Inventors: Fabian Alexander WOLF, John BRADLEY, Xiaoji SUN, Nicholas McCartney PLUGIS
  • Patent number: 12157893
    Abstract: The present disclosure relates to compositions and methods for improving site-directed integration frequency in the genome of plant cells.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: December 3, 2024
    Assignee: Monsanto Technology LLC
    Inventors: John Bradley, Larry A. Gilbertson, Ervin Nagy, Christine Shyu, Peizhen Yang, Xudong Ye
  • Publication number: 20220162625
    Abstract: The present disclosure relates to compositions and methods for improving site-directed integration frequency in the genome of plant cells.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 26, 2022
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: John BRADLEY, Larry A. GILBERTSON, Ervin NAGY, Christine SHYU, Peizhen YANG, Xudong YE
  • Publication number: 20190373040
    Abstract: Systems and methods for stream data encoding.
    Type: Application
    Filed: May 6, 2019
    Publication date: December 5, 2019
    Inventors: Stuart Grubbs, John Bradley, William A. Kelleher
  • Publication number: 20160227790
    Abstract: Compositions and methods of phytopathogenic fungus control are provided, the compositions and methods include a first component of dissolved organic matter (DOM) concentrate having natural organic matter of defined composition, suitable for soil, foliar, and seed coating.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 11, 2016
    Inventors: Terry J. Hanson, Kenneth Scott Day, John Bradley
  • Patent number: 9175273
    Abstract: Methods and compositions for use in reducing biotic stress in plants by providing recombinant DNA molecules encoding methkyletone thioesterase into the cells of a plant in order to achieve a reduction in infestation by nematodes, insects and other pests are described. The plant cells in some cases produce one or more of 2-nonanone, 2-undecanone, 2-tridecanone and 2-pentadecanone. Also described are methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from pest infestations.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: November 3, 2015
    Assignee: Monsanto Technology LLC
    Inventors: John Bradley, Michael J. Crawford, William P. Haakenson, Jr., Michelle Coutu Hresko, Deryck J. Williams, Amy L. Caruano-Yzermans
  • Publication number: 20150250185
    Abstract: Compositions and methods of phytopathogenic fungus control are provided, the compositions and methods include a first component of dissolved organic matter (DOM) concentrate having natural organic matter of defined composition, suitable for soil, foliar, and seed coating.
    Type: Application
    Filed: September 13, 2013
    Publication date: September 10, 2015
    Inventors: Terry J. Hanson, Kenneth Scott Day, John Bradley
  • Patent number: 9081017
    Abstract: This invention relates to the identification and characterization of specific cellular responses which are associated with tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 1 (TNFR2). Selective modulation of these tumor necrosis factor receptors (TNFRs) Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFR1 and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFR1 and TNFR2 modulators useful in such methods.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: July 14, 2015
    Assignees: Cambridge Enterprise Limited, Yale University
    Inventors: John Bradley, Jordan Pober, Paul Clark, Wang Min, Martin Kluger
  • Publication number: 20130324247
    Abstract: A system and method are disclosed for presenting an event to a user while allowing a user to make a prediction during the event, allowing the user to choose different content while viewing the event, displaying the chosen content while also displaying the event in an intelligent manner and providing a jump bar to navigate between content and/or features.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 5, 2013
    Inventors: Christopher Esaki, David Seymour, William Mozell, John Bradley, Evan Brandt, Mike Christian, Ryan Cleven, Ryan Crandall, Scott Gardner, Patrick Moody Grigsby, Ashish Gupta, Vernon Hui, David Jurenka, Mike Mahar, Preet Mangat, Brian Ostergren, Bob Settles, Michael Siebert, Todd Stevens, Josh Trusz, Ryan Wilson, Nathan Charley, Henry Watson, Mark Findlay, Adam Potratz
  • Publication number: 20130067620
    Abstract: Methods and compositions for use in reducing biotic stress in plants by providing recombinant DNA molecules encoding methkyletone thioesterase into the cells of a plant in order to achieve a reduction in infestation by nematodes, insects and other pests are described. The plant cells in some cases produce one or more of 2-nonanone, 2-undecanone, 2-tridecanone and 2-pentadecanone. Also described are methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from pest infestations.
    Type: Application
    Filed: February 14, 2011
    Publication date: March 14, 2013
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: John Bradley, Michael J. Crawford, William P. Haakenson, JR., Michelle Coutu Hresko, Deryck J. Williams, Amy L. Caruano-Yzermans
  • Publication number: 20110270751
    Abstract: A system and method for establishing two-factor security using a mobile device comprising authorizing one or more transactions requests received by a server, identifying one or more credentials required before the transaction can be processed, transmitting the list of credentials and a request session ID to a mobile device that stores, or is linked to, one or more required credentials, and pushing (or authorizing a credentials server to push) such credentials to the server that received the request in order to permit the associated transaction and/or upgrade the prior session to a secured or “authorized” connection.
    Type: Application
    Filed: December 7, 2010
    Publication date: November 3, 2011
    Inventors: Andrew Csinger, John Bradley, Sven Olsen, Rich Cannings
  • Publication number: 20110168128
    Abstract: The present application describes systems for water retrieval from the engine exhaust. This collected water can be used both for removing ethanol from ethanol-gasoline blends, and for use as a knock suppressant. The water that is removed from the exhaust can be used as the only source of water or in combination with water that is externally supplied. The present application also describes new means for removal of water from the exhaust that can be employed for applications. In some embodiments, an auto-heat exchanger is employed to recover water from the engine exhaust.
    Type: Application
    Filed: June 25, 2010
    Publication date: July 14, 2011
    Applicant: ETHANOL BOOSTING SYSTEMS LLC
    Inventors: John Bradley, Leslie Bromberg, Daniel Cohn
  • Publication number: 20100274645
    Abstract: A user directed advertisement network includes an ad server having a database for storing advertisements from one or more vendors, and a broker configured with software to receive and store claims including information of advertisement preferences of a principal, and based upon at last one claim to provide to the principal one or more advertisements stored on the ad server that relate to the preferences of the principal. An agent used by the principal and configured with software to provide the claims including the information of the advertisement preferences to the broker, and to receive the advertisements from the broker.
    Type: Application
    Filed: November 12, 2009
    Publication date: October 28, 2010
    Inventors: Paul Trevithick, Drummond Reed, Markus Sabadello, Thomas Carroll, John Bradley, Brian Walker
  • Publication number: 20100250955
    Abstract: A brokered information sharing system including a primary broker configured with software to store cards of a principal, to transmit the cards when requested by the principal, to authenticate the principal, and to provide a master authentication of the principal to at least one issuing party. A selector is used by the principal and is configured with software to provide authentication of the principal to the primary broker, and to request and receive cards from the primary broker.
    Type: Application
    Filed: October 22, 2009
    Publication date: September 30, 2010
    Inventors: Paul Trevithick, Drummond Reed, Markus Sabadello, Thomas Carroll, John Bradley, Brian Walker
  • Publication number: 20080222706
    Abstract: A computer security monitoring method and system includes receiving input data, wherein the input data includes user account data associated with a user's security-related interaction with a particular network, security-related local network data associated with the particular network, and security-related external network data regarding security threats at one or more independent, external networks. The input data is analyzed to generate at least one composite security status score, wherein the analyzing includes an analysis of the user account data based on previously stored data associated with the user account, and an analysis of the security-related local and external network data to adjust the composite security status score when the analysis of the security-related local and external network data indicates an increased security threat. The method and system may produce human-readable output including an alert associated with the at least one composite security status score.
    Type: Application
    Filed: March 6, 2007
    Publication date: September 11, 2008
    Inventors: Martin Renaud, Patrick Audley, John Bradley
  • Publication number: 20080176796
    Abstract: This invention relates to the identification and characterisation of specific cellular responses which are associated with tumour necrosis factor receptor 1 (TNFR1) and tumour necrosis factor receptor 1 (TNFR2). Selective modulation of these tumour necrosis factor receptors (TNFRs) Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFR1 and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFR1 and TNFR2 modulators useful in such methods.
    Type: Application
    Filed: April 11, 2006
    Publication date: July 24, 2008
    Inventors: John Bradley, Jordan Pober, Paul Clark, Wang Min, Martin Kluger
  • Publication number: 20070144675
    Abstract: A method of indelibly marking a label (10) which includes a substrate (11) (which is transparent or translucent) and an adhesive layer (12). The method includes applying a marking (14) to the adhesive layer (12) such that the marking is visible through the substrate. The marking (14) can include part thereof in a mirror or reverse image of that which is to be visible through the substrate. The marking can be applied by ink-jet, hot-wax or laser marking (13).
    Type: Application
    Filed: October 15, 2004
    Publication date: June 28, 2007
    Applicant: LEYHATTON INNOVATIONS LIMITED
    Inventors: John Bradley, Michael Voss
  • Publication number: 20070028467
    Abstract: The pendulum bow sight is a sight apparatus for an archery bow that provides a luminescent sighting element disposed without the use of supporting pins in a field of view of an optic lens without obstructing the field of view used for sighting a target. The sight apparatus provides unobstructed viewing through a pendulum sight regardless of a bow elevation angle. The pendulum sight has a pivoting lens assembly, which is suspended by a supporting structure capable of being mounted to e.g., the riser of a bow. The bow sight lens assembly is freely rotatable about a pivot axis disposed across a region encompassed by the supporting structure. The pendulum bow sight provides independent horizontal and vertical adjustments of the sighting element for calibration that is good for up to thirty-five yards, and with any bow elevation angle.
    Type: Application
    Filed: August 4, 2006
    Publication date: February 8, 2007
    Inventors: John Bradley, Brian Bowen
  • Publication number: 20070009981
    Abstract: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.
    Type: Application
    Filed: January 5, 2006
    Publication date: January 11, 2007
    Inventors: Deryck Williams, Merry McLaird, Michelle Hresko, Anita Frevert-Thompson, Ronald Worthington, Andrew Kloek, Jennifer Davila-Aponte, John Bradley, Siqun Xu