Abstract: A diode-laser module includes a diode-laser delivering radiation having a wavelength less than 450 nm and located a housing. Focusing optics focus the radiation into a single-mode optical fiber located in the housing. The radiation is focused through an end-cap bonded to the single-mode fiber and having a diameter greater than the core-diameter of the single-mode fiber. The length of the end-cap is selected cooperative with the focusing optics such that the beam intensity at the entrance end of the end-cap is below a level that would cause photodecomposition of any gaseous hydrocarbons in the housing.

Abstract: An optical fiber assembly includes a clad optical fiber having an end-cap thereon. Radiation is focused into the optical fiber via the end-cap. A roughened portion of the fiber cladding behind the end-cap allows any radiation focused into the fiber and propagating in the cladding to escape the optical fiber. A concave reflector surrounding the optical fiber reflects the escaped radiation away from the fiber assembly. A connector for connecting the optical fiber to a laser includes an air-cooled beam-dump for receiving the radiation reflected away from the optical fiber.

Abstract: An apparatus for transmitting laser light and redirecting the light laterally relative to an axis of the apparatus includes an optical fiber having a core and a cladding surrounding the core. The core terminates at a core end. The cladding terminates at a cladding end spaced from the core end to expose an exposed length of the core. A tubular member surrounds at least a distal portion of the fiber and has a closed distal end. The exposed length of the core is bent for the core end to oppose a side of said tubular member. The core end is bonded to the side of the tubular member. A seal creates a sealed volume of the tubular member surrounding said exposed length. The volume may contain a vacuum or a gas such as air.

Abstract: An apparatus for transmitting laser light and redirecting the light laterally relative to an axis of the apparatus includes an optical fiber having both a core and a cladding surrounding the core. The optical fiber terminates at a distal tip having a surface inclined relative to the axis of the optical fiber. A tubular member surrounds the optical fiber at its distal end. The distal end of the optical fiber has a portion opposing the tubular member for being united to the tubular member. The distal portion is joined to the tubular member by an intermediate material selected to have an index of refraction matching that of the core and the tubular member.

Abstract: The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and a polyelectrolytic complex of hyaluronic acid and chitosan. These three components in combination constitute an initial microenvironment for support of stromal cells, and their undifferentiated mesenchymal cell progeny. The tissue engineering device and method of forming the same comprising hyaluronic acid and chitosan and the use of said device with compositions of pluripotent cells and various formulations of cell culture media for repair of tissues is disclosed.

Abstract: An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. Another embodiment is arranged for the local delivery of therapeutic agent. A preferred embodiment is a porous resorbable implant, wherein the therapy delivery may be localized in nature, rather than systemic, such that higher doses at the target site may be allowed than would be tolerable by the body systemically.

Abstract: An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region's macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.