Patents by Inventor John Brognard

John Brognard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Akt inhibitors, pharmaceutical compositions, and uses thereof
    Patent number: 7378403
    Abstract: Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: May 27, 2008
    Assignees: The United States of America as represented by the Department of Health and Human Services, Georgetown University
    Inventors: Alan P. Kozikowski, Phillip Dennis, Haiying Sun, John Brognard
  • Compositions and Methods for Treating Diseases Associated With Phlpp
    Publication number: 20080108569
    Abstract: The present invention relates generally to PHLPP, a novel phosphatase that inactivates Akt (protein kinase B) by directly dephosphorylating the hydrophobic domain of the C-terminus. More specifically, the invention relates to PHLPP polynucleotides and the polypeptides encoded by these polynucleotides and the use of these polynucleotides and polypeptides in the treatment and diagnosis of biological conditions mediated by Akt phosphorylation, particularly cancer. This invention relates to PHLPP polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PHLPP polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PHLPP polynucleotides and polypeptides of the invention.
    Type: Application
    Filed: March 31, 2006
    Publication date: May 8, 2008
    Applicant: The Regents of the University of California
    Inventors: Alexandra Newton, Tianyan Gao, John Brognard
  • Akt inhibitors, pharmaceutical compositions, and uses thereof
    Publication number: 20050272708
    Abstract: Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors.
    Type: Application
    Filed: September 3, 2003
    Publication date: December 8, 2005
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Alan Kozikowski, Phillip Denis, Haiying Sun, John Brognard