Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: Process for making a fragmentation warhead using hot isostatic pressing where tungsten spheres, powdered steel, and interlock features on a mandrel are consolidated in a matrix. Then in the finished part, the front fragmentation cap, rear and interior geometries are machined, resulting in a finished warhead with an enhanced performance fragmentation cap integrally bonded to it.

Abstract: An upright vacuum cleaner comprising a vac-motor for drawing dirty air in through a floor-engaging cleaner head on the vacuum cleaner, a separating apparatus for separating dirt from the dirty air, an elongate air duct for carrying air to or from the separating apparatus, and a suction wand which is stored on the vacuum cleaner and which can be connected to the separating apparatus via a hose as required to clean above the floor. The external surface of the air duct defines an elongate recess for receiving the stored suction wand such that the air duct partly surrounds the stored wand. This provides a compact configuration.

Abstract: A safety platform scaffold apparatus is provided having a plurality of wall-supportable units, each with a floor support portion. A work platform is removably mountable on the floor support portions by suitable connectors affixed to the opposed ends of the platform. The opposed connectors are complimentary to each other so that they can be nested together on the same floor support portion thereby enabling a multiplicity of wall supportable units to be mounted on a wall with juxtaposed side-by-side platforms defining a smooth, flat, continuous work surface and wherein the platforms interlock with each other and the wall-supportable unit floor portions.

Abstract: An upright vacuum cleaner comprising a vac-motor for drawing dirty air in through a floor-engaging cleaner head on the vacuum cleaner, a separating apparatus for separating dirt from the dirty air, an elongate air duct for carrying air to or from the separating apparatus, and a suction wand which is stored on the vacuum cleaner and which can be connected to the separating apparatus via a hose as required to clean above the floor. The external surface of the air duct defines an elongate recess for receiving the stored suction wand such that the air duct partly surrounds the stored wand. This provides a compact configuration.

Abstract: A portable safety platform scaffold apparatus includes a plurality of wall-supportable units for being supported by the top portion of a wall. The wall support units each include a wall-top engagement portion, a common removable floor member, and a common removable fence. With the apparatus, a worker can stand on the floor members with the wall-top engagement portions secured on the top of the wall. In this way, the worker is in a safe location when a roof truss is lowered onto the wall.

Abstract: A fan assembly for creating an air current includes an air inlet, an air outlet, an impeller, a motor for rotating the impeller to create an air flow passing from the air inlet to the air outlet, the air outlet comprising an interior passage for receiving the air flow and a mouth for emitting the air flow, the air outlet defining an opening through which air from outside the fan assembly is drawn by the air flow emitted from the mouth, a control circuit for controlling the motor, a remote control for transmitting control signals to the control circuit, and a plurality of magnets angularly spaced about the air outlet to provide a plurality of angularly spaced docking positions for the remote control on the air outlet.

Abstract: A fan assembly includes a device for creating an air flow and an air outlet for emitting the air flow. The air outlet is mounted on a stand for conveying the air flow to the air outlet. The fan assembly also includes a tilt mechanism for tilting the air outlet relative to at least part of the stand. The tilt mechanism comprises a flexible hose defining, at least in part, an air passage through the tilt mechanism.

Abstract: A fan assembly includes a device for creating an air flow and an air outlet for emitting the air flow. The air outlet is mounted on a stand for conveying the air flow to the air outlet. The fan assembly also includes a tilt mechanism for tilting the air outlet relative to at least part of the stand. The tilt mechanism comprises a flexible hose defining, at least in part, an air passage through the tilt mechanism.

Abstract: A fan assembly for creating an air current includes an air inlet, an air outlet, an impeller, a motor for rotating the impeller to create an air flow passing from the air inlet to the air outlet, the air outlet comprising an interior passage for receiving the air flow and a mouth for emitting the air flow, the air outlet defining an opening through which air from outside the fan assembly is drawn by the air flow emitted from the mouth, a control circuit for controlling the motor, a remote control for transmitting control signals to the control circuit, and a plurality of magnets angularly spaced about the air outlet to provide a plurality of angularly spaced docking positions for the remote control on the air outlet.

Abstract: A fan assembly includes a device for creating an air flow and an air outlet for emitting the air flow. The air outlet is mounted on a stand for conveying the air flow to the air outlet. The fan assembly also includes a tilt mechanism for tilting the air outlet relative to at least part of the stand. The tilt mechanism comprises a flexible hose defining, at least in part, an air passage through the tilt mechanism.

Abstract: A fan assembly for creating an air current includes an air inlet, an air outlet, an impeller, a motor for rotating the impeller to create an air flow passing from the air inlet to the air outlet, the air outlet comprising an interior passage for receiving the air flow and a mouth for emitting the air flow, the air outlet defining an opening through which air from outside the fan assembly is drawn by the air flow emitted from the mouth, a control circuit for controlling the motor, a remote control for transmitting control signals to the control circuit, and at least one magnet for attaching the remote control to the air outlet.

Abstract: A pedestal for a fan assembly includes a telescopic duct for conveying an air flow to an outlet of the fan assembly. The duct includes an outer tubular member having a first stop member, an inner tubular member located at least partially within and slidable relative to the outer tubular member, the inner tubular member having a second stop member for engaging the first stop member to inhibit withdrawal of the inner tubular member from the outer tubular member, and a mainspring rotatably mounted on the second stop member, the mainspring having a free end retained by the first stop member.

Abstract: A cleaning appliance such as a vacuum cleaner includes a main body housing a motor and fan unit for generating a fluid flow. The main body also houses a removable pre-motor filter located upstream of the motor and fan and a removable post-motor filter located downstream of the motor and fan. It is beneficial to permit the user to be able to monitor the condition of both the pre-motor filter and the post-motor filter, and to remove and replace them as required, and so access to both filters may be provided. It is more important that the user checks the pre-motor filter as it gets dirtier than the post-motor filter. Therefore, the post-motor filter is not accessible or removable from the main body until the pre-motor filter is removed from the main body, by removing its housing.

Abstract: The present invention relates to isoquinolinone derivatives of formula (I): wherein are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: A fan assembly for creating an air current includes an air inlet, an air outlet, an impeller, a motor for rotating the impeller to create an air flow passing from the air inlet to the air outlet, the air outlet comprising an interior passage for receiving the air flow and a mouth for emitting the air flow, the air outlet defining an opening through which air from outside the fan assembly is drawn by the air flow emitted from the mouth, a control circuit for controlling the motor, a remote control for transmitting control signals to the control circuit, and at least one magnet for attaching the remote control to the air outlet.

Abstract: A fan assembly includes a device for creating an air flow and an air outlet for emitting the air flow. The air outlet is mounted on a stand for conveying the air flow to the air outlet. The fan assembly also includes a tilt mechanism for tilting the air outlet relative to at least part of the stand. The tilt mechanism comprises a flexible hose defining, at least in part, an air passage through the tilt mechanism.

Abstract: A pedestal for a fan assembly includes a telescopic duct for conveying an air flow to an outlet of the fan assembly. The duct includes an outer tubular member having a first stop member, an inner tubular member located at least partially within and slidable relative to the outer tubular member, the inner tubular member having a second stop member for engaging the first stop member to inhibit withdrawal of the inner tubular member from the outer tubular member, and a mainspring rotatably mounted on the second stop member, the mainspring having a free end retained by the first stop member.

Abstract: A cleaning appliance such as a vacuum cleaner includes a main body housing a motor and fan unit for generating a fluid flow. The main body also houses a removable pre-motor filter located upstream of the motor and fan and a removable post-motor filter located downstream of the motor and fan. It is beneficial to permit the user to be able to monitor the condition of both the pre-motor filter and the post-motor filter, and to remove and replace them as required, and so access to both filters may be provided. It is more important that the user checks the pre-motor filter as it gets dirtier than the post-motor filter. Therefore, the post-motor filter is not accessible or removable from the main body until the pre-motor filter is removed from the main body, by removing its housing.