Abstract: Examples of the disclosure data enable interactions of a user with an object to be used to improve the classification of the object in mediated reality applications. In examples of the disclosure LiDAR data is obtained from a mediated reality device. The mediated reality device is used by a user and the LiDAR data includes data points representing at least part of an object. Position data relating to a position of the user's hand relative to the object is obtained and interaction data indicating how the user's hand is interacting with the object is also obtained. At least some of the interaction data is obtained from an electromyography device coupled to the user. The position data is used to map the interaction data to the LiDAR data to enable the interaction data to be used to classify the object.

Abstract: The present disclosure provides food supplements comprising proteases that can digest a variety of food proteins to enhance their protein bioavailability in the gut.

Abstract: A nutrient recycling device is provided that is configured to collect digestive contents from a first opening of a gastrointestinal (GI) tract and recycle and/or return the digestive contents to a second location in a patient's gastrointestinal tract. The device and associated method may find application in patients with a number of complaints, such as short bowel syndrome and/or prior to stoma reversal surgery. The device comprises a bag adapted to receive the digestive contents from a first GI opening, and a pump incorporated with the bag adapted to pump the digestive contents to a second GI location. The pump includes an inlet in fluid communication with the interior of the bag, and an outlet connected to an outlet conduit adapted to provide a flow pathway for the digestive content to flow from the pump to second GI location.

Abstract: An apparatus, method and computer program is described comprising: detecting, at a second user device, one or more display patterns displayed at a display of a first user device, wherein the one or more display patterns comprise features with spatial variations configured to be detected by a radar module of the second user device; determining at least one of an orientation, position, or size of the first user device based, at least in part, on the one or more display patterns; and determining at least one of an orientation or position of the second user device relative to the first user device within a coordinate system of the first user device.

Abstract: Various aspects and embodiments are directed to a streamlined computer device and a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Various views of digital media content permits users to easily and efficiently access various digital media content. Different views are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to maintain and manage digital media content libraries. According to some embodiments, the libraries comprise user digital media content and references digital media content. Functionality provided to a user can be tailored to the type of content displayed, accessed and/or managed. According to various aspects, methods and systems are provided for accessing and managing digital media libraries on a streamlined computing device with a plurality selectable I/O profiles.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: An apparatus, method and computer program is described including: generating a display pattern including features with spatial variations, wherein the spatial variations are configured to enable determination, by a first radar device, of at least one of an orientation of a first user device, position of the first user device, size of a display of the first user device, or one or more gestures associated with the display.

Abstract: Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: Embodiments of the present disclosure provide a method for identifying those entities within a network that have the most influence on other entities within the network. A multi-relational network comprising links among a plurality of physicians is generated based on peer network data, wherein each link indicates a first physician that influences a second physician, and a weight of the influence. A decision by a treating physician of the plurality of physicians is decomposed, using a deep learning engine, into a magnitude of peer influence and a magnitude of control factor influence based on the multi-relational network and a plurality of control factors respectively. The magnitude of peer influence among one or more physicians in the multi-relational network is distributed among physicians in the multi-relational network based on the links each physician maintains with other physicians.

Abstract: An anode apparatus for mounting on an external surface of a concrete structure to provide cathodic protection of metal members in the concrete uses a pre-assembled body which is typically elongate carrying a longitudinal anode, which can be sacrificial or impressed current, together with a supporting material having a front face for attachment to the surface and an impermeable plastic covering material at the rear face covering the anode and the supporting material when the front face is attached to the surface of the concrete. A channel defined on the front face is arranged to receive a layer of a conformable ionically conductive adhesive material for attachment to the external surface. A distance of the edge of the covering material is arranged to be similar to a distance of the metal from the external surface such that wetting and drying effects of environmental moisture are the same for the anode as for the metal components.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.

Abstract: Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.

Abstract: The invention provides a method of selectively characterising polynucleotides of a desired property, such as length, using a nanopore, based on the translocation of the polynucleotide through or across the nanopore. Kits and systems for use in such methods are also provided. The methods of the invention are particularly suitable for sequencing polynucleotides such as DNA.

Abstract: This application relates to audio driving circuitry (100), and in particular to audio driving circuitry for outputting first and second audio driving signals for driving a stereo audio load (106), which may be a stereo audio load of an accessory apparatus (102) removably coupled to the audio driving circuitry in use. A load monitor (111) is provided for monitoring to monitor, from a monitoring node (112), an indication of a common mode return current passing through a common return path, together with an indication of a common mode component of the first and second audio driving signals and to determine an impedance characteristic of the stereo audio load. The load monitor (111) can provide dynamic monitoring of any significant change in load impedance. In some embodiments the load monitor (111) comprises an adaptive filter (301) which adapts a parameter of the filter which is related to the load impedance so as to determine the indication of load impedance.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: Disclosed herein are surgical mesh materials and methods of production and use thereof.

Abstract: This application relates to audio driving circuitry (100), and in particular to audio driving circuitry for outputting first and second audio driving signals for driving a stereo audio load (106), which may be a stereo audio load of an accessory apparatus (102) removably coupled to the audio driving circuitry in use. A load monitor (111) is provided for monitoring to monitor, from a monitoring node (112), an indication of a common mode return current passing through a common return path, together with an indication of a common mode component of the first and second audio driving signals and to determine an impedance characteristic of the stereo audio load. The load monitor (111) can provide dynamic monitoring of any significant change in load impedance. In some embodiments the load monitor (111) comprises an adaptive filter (301) which adapts a parameter of the filter which is related to the load impedance so as to determine the indication of load impedance.

Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.