Abstract: Embodiments disclosed herein relate to medical procedures. Particularly disclosed are systems and methods for positioning a percutaneous access device for use with imaging sensors. A positioning apparatus is described, which may comprise at least one imaging device coupled to a guide device. The guide device may comprise a base plate and a guide member pivotally coupled to the base plate. The guide member may be configured with an alignment feature in which a percutaneous access device may rest. The at least one imaging device may comprise an imaging probe or a docking station configured to receive an imaging probe. Movement of the guide member and the one or more imaging devices may be coupled to facilitate imaging of sub-surface structures toward which the guide member and accompanying percutaneous access device are angled. A method of using a positioning apparatus to position a percutaneous access device is also described.