Abstract: A tamper evident tip cap assembly for a prefilled dosage syringe having a tip cap wherein a sleeve is frangibly connected to the tip cap, and is captured within an overcap freely rotatable thereon. The tamper evident tip cap assembly is removed from the syringe tip cap by pulling the overcap to break the frangible connection between the sleeve and syringe tip cap.

Abstract: A tamper evident tip cap assembly for a prefilled dosage syringe having a tip cap wherein a sleeve is frangibly connected to the tip cap, and is captured within an overcap freely rotatable thereon. The tamper evident tip cap assembly is removed from the syringe tip cap by pulling the overcap to break the frangible connection between the sleeve and syringe tip cap.

Abstract: Compositions containing opioid antagonists are disclosed, particularly alvimopan and its active metabolite in solid dosage forms, where the drug is uniformly distributed, achieves the desired bioavailability, and is stable. Methods of preparing and using the compositions containing opioid antagonists are also disclosed. The results are achieved by a combination of processing techniques and component selection.

Abstract: A moisture-tight safety closure and a container wherein a depending, circumferentially extending sealing lip on the closure engages a flexible wall portion on the neck of the container. A plurality of circumferentially extending lugs on the closure cooperate with a plurality of circumferentially spaced hooks on the container neck for releasably securing the closure to the container.

Abstract: A moisture-tight safety closure and a container wherein a depending flexible, circumferentially extending sealing lip on the closure engages a radius finish on the neck of the container. A plurality of circumferentially extending lugs on the closure cooperate with a plurality of circumferentially spaced hooks on the container neck for releasably securing the closure to the container.

Abstract: A dispenser assembly for liquid products comprising an elongated, generally cylindrical barrel of a predetermined internal cross-sectional diameter having a discharge opening at one end and open at its opposite end, an elongated, generally cylindrical hollow plunger having an outer diameter less than the barrel internal diameter and a circumferentially extending axially directed sealing lip adjacent the tip portion having an outer diameter greater than the internal diameter of the barrel in the relaxed state to thereby flex the lip inwardly against its bias and providing the sole sliding contact between the plunger and barrel when the plunger and barrel are actuated axially relative to one another.

Abstract: Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.

Abstract: The combination comprising a container for a liquid medicament product having a discharge opening at one end and external screw threads, an elongated hollow barrel having a cap portion with internal threads to facilitate assembly to the container anteriorly thereof an elongated hollow plunger engageable in the barrel having an axially circumferentially extending axially directed lip of a diameter in the relaxed state slightly greater than the internal diameter of the barrel to facilitate easy movement of the plunger in the barrel to draw liquid medicament into the barrel and discharge the same on a reverse stroke, a cap of cup-like form and of an internal diameter greater than the cap portion of the barrel having a seal adapted positioned to engage the cap portion of the barrel when assembled to the container.

Abstract: An environment for developing clientside/serverside code is disclosed. The environment supports the perception that the server space and client space are seamlessly joined into a single program execution space. An outgrowth of the single execution space includes effective event handling on the server through enabling created objects to migrate effectively between the server and client.

Abstract: A method is disclosed for creating and editing event handlers that link events triggered on one object to actions taken on one or more different objects. The method provides a user interface having an event pane, action pane and code pane. A user selects an event icon in the event pane to link that event to a desired action in the action pane. The code that is generated in the code pane can be displayed in either a list view or a code view. In the list view, the event handler is presented to the user in simple, concise statements that are easy for the user to understand. In the code view, the actual event handler code in either VBScript or JavaScript languages is presented to the user.

Abstract: A method and system for creating and editing event handlers that link events triggered on one object to actions taken on one or more different objects. The method provides a user interface having an event pane, action pane and codepane. A user selects an event icon in the event pane to link that event to a desired action in the action pane. The code that is generated in the code pane can be displayed in either a list view or a code view. In the list view, the event handler is presented to the user in simple, concise statements that are easy for the user to understand. In the code view, the actual event handler code in either VBScript or JavaScript languages is presented to the user.

Abstract: A non-aqueous, chewable composition for oral delivery of unpalatable drugs is provided. The composition contains the drug intimately dispersed or dissolved in a pharmaceutically acceptable lipid that is solid at room temperatures. The composition also has a matrix that contains a granulating agent for the total composition and a rapid dispersal agent and optionally additives such as buffering agents, flavoring agents, surfactants and the like.