Abstract: Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.

Abstract: Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present.

Abstract: Specific conjugates containing maytansines and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates.

Abstract: The present invention concerns a process for the preparation of an antibody conjugate comprising the step of reacting an engineered antibody having a single inter-heavy chain disulfide bond with a conjugating reagent that forms a bridge between the two cysteine residues derived from the disulfide bond.

Abstract: A transport device has a chassis with a front end and a rear end. The device has a continuous track supporting the chassis above a surface configured to move the chassis along the surface. A handle extends from the front end or rear end of the chassis and has a grip section positioned to be gripped by a user walking ahead of or behind the chassis. A motor is coupled and arranged to drive the continuous track and is operable by a user manipulating the handle. The worktop can be reconfigurable to at least two optional arrangements having different storage or support capabilities. The worktop can also be interchangeable with other different worktops having different storage or support capabilities.

Abstract: A transport device has a chassis with a front end and a rear end. The device has a continuous track supporting the chassis above a surface configured to move the chassis along the surface. A handle extends from the front end or rear end of the chassis and has a grip section positioned to be gripped by a user walking ahead of or behind the chassis. A motor is coupled and arranged to drive the continuous track and is operable by a user manipulating the handle. The worktop can be reconfigurable to at least two optional arrangements having different storage or support capabilities. The worktop can also be interchangeable with other different worktops having different storage or support capabilities.