Patents by Inventor John C. Amedio

John C. Amedio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS OF {5-CYCLOPROPYL-2-[2-(3,6-DIFLUORO¬PYRIDIN-2-YLAMINO)-PYRIDIN-4-YL]-PYRIDO[3,4-D]PYRIMIDIN-4-YL }-( (S)-3,3-DIMETHYL-PIPERIDIN-4-YL)-AMINE
    Publication number: 20260209221
    Abstract: Disclosed herein are solid forms (e.g., crystalline forms) of 4-(5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole (Compound 1), and compositions, pharmaceutical compositions, kits, methods, and uses thereof. The compounds disclosed herein are inhibitors of atypical protein kinase C (aPKC) and their solid forms are therefore useful for the treatment and/or prevention of basal cell carcinoma.
    Type: Application
    Filed: December 12, 2023
    Publication date: July 23, 2026
    Applicant: WINDTREE THERAPEUTICS, INC.
    Inventor: John C. AMEDIO
  • Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
    Patent number: 8664201
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups and A+ is an ammonium cation.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: March 4, 2014
    Assignee: Ziopharm Oncology, Inc.
    Inventors: Frank Walter Waligora, John C. Amedio
  • Optically pure and enriched isomers of chelating ligands and contrast agents
    Patent number: 8048906
    Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 1, 2011
    Assignee: Catalyst Medical
    Inventors: John C. Amedio, Peter D. Caravan, Vincent Jacques, Kevin L. Zhou, Stuart Levy, Shirley Kalogeropoulos, Matthew Greenfield
  • SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
    Publication number: 20110212921
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups and A+ is an ammonium cation.
    Type: Application
    Filed: July 30, 2009
    Publication date: September 1, 2011
    Applicant: ZIOPHARM ONOCOLOGY, INC.
    Inventors: Frank Walter Waligora, John C. Amedio
  • Peptide-based multimeric targeted contrast agents
    Patent number: 7927581
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: April 19, 2011
    Assignee: Factor 1A, LLC
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Salts of isophosphoramide mustard and analogs thereof
    Publication number: 20080255056
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Applicant: ZIOPHARM Oncology, Inc.
    Inventors: John C. Amedio, Barbara P. Wallner, Philip B. Komarnitsky
  • Peptide-based multimeric targeted contrast agents
    Patent number: 7238341
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: July 3, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Targeting multimeric imaging agents through multilocus binding
    Publication number: 20040005274
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John C. Amedio, Peter D. Caravan, Zhaoda Zhang, Shrikumar Nair, Robert M. Weisskoff
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030180222
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: September 25, 2003
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Process for synthesizing phosphodiesters
    Patent number: 5919967
    Abstract: A process for preparing a phosphodiester of the formula: ##STR1## is described that involves (1) reaction of a first alcohol with phosphorous trichloride to form a phosphorodichlorodite, (2) reaction of the phosphorodichlorodite with an amine to form a phosphorodiamidite, (3) reaction with a second alcohol (which may be the same as the first alcohol) to form a phosphoramidite diester, and finally, (4) hydrolysis and oxidation of the phosphoramidite to form the phosphodiester. R and R1 may represent aliphatic, aromatic, heterocyclic, peptidic, peptoid, deoxyribo- or ribonucleotidic or nucleosidic, or organic chelating moieties.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: July 6, 1999
    Assignee: EPIX Medical, Inc.
    Inventors: John C. Amedio, Paul J. Bernard, Mark Fountain