Patents by Inventor John C. Amedio

John C. Amedio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS OF PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS
    Publication number: 20230192707
    Abstract: The present disclosure provides solid forms of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, and methods of preparing and using the same.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 22, 2023
    Inventors: Caroline Yvette PROULX-LAFRANCE, John C. AMEDIO, JR., Erika VOLCKOVA
  • SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
    Publication number: 20220064181
    Abstract: The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
    Type: Application
    Filed: August 3, 2021
    Publication date: March 3, 2022
    Inventors: Katy Alexander, John C. Amedio, JR., Selcuk Calimsiz, Michael Geier, Geraldine C. Harriman, Sijun Hu, Jon P. Lawson, Henry Morrison, Kyle Sabourin, Mark E. Scott, Vimal Varghese, Kunal Arvind Varia, Xiaotian Wang, Xiaowei Yang
  • SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
    Publication number: 20200148699
    Abstract: The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
    Type: Application
    Filed: October 10, 2019
    Publication date: May 14, 2020
    Inventors: Katy Alexander, John C. Amedio, JR., Selcuk Calimsiz, Michael Geier, Geraldine C. Harriman, Sijun Hu, Jon P. Lawson, Henry Morrison, Kyle Sabourin, Mark E. Scott, Vimal Varghese, Kunal Arvind Varia, Xiaotian Wang, Xiaowei Yang
  • SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
    Publication number: 20190225623
    Abstract: The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
    Type: Application
    Filed: December 12, 2018
    Publication date: July 25, 2019
    Inventors: Katy Alexander, John C. Amedio, JR., Selcuk Calimsiz, Michael Geier, Geraldine C. Harriman, Sijun Hu, Jon P. Lawson, Henry Morrison, Kyle Sabourin, Mark E. Scott, Vimal Varghese, Kunal Arvind Varia, Xiaotian Wang, Xiaowei Yang
  • Solid forms of a thienopyrimidinedione ACC inhibitor and methods for production thereof
    Patent number: 10183951
    Abstract: The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: January 22, 2019
    Assignee: Gilead Apollo, LLC
    Inventors: John C. Amedio, Jr., Sijun Hu, Henry Morrison
  • SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
    Publication number: 20170267690
    Abstract: The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.
    Type: Application
    Filed: March 1, 2017
    Publication date: September 21, 2017
    Inventors: Katy Alexander, John C. Amedio, JR., Selcuk Calimsiz, Michael Geier, Geraldine C. Harriman, Sijun Hu, Jon P. Lawson, Henry Morrison, Kyle Sabourin, Mark E. Scott, Vimal Varghese, Kunal Arvind Varia, Xiaotin Wang, Xiaowei Yang
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20160304546
    Abstract: The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides novel crystalline forms of organic arsenic compounds and methods for their use in treating cancers such as leukemia and solid tumors. Specifically, a crystalline form of darinaparsin, wherein the crystalline form has a melting point in the range of about 190-200 deg C.
    Type: Application
    Filed: December 5, 2014
    Publication date: October 20, 2016
    Applicant: SOLASIA PHARMA K.K.
    Inventor: John C. Amedio, Jr.
  • SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
    Publication number: 20160215005
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
    Type: Application
    Filed: January 4, 2016
    Publication date: July 28, 2016
    Inventors: Frank W. WALIGORA, John C. AMEDIO, JR.
  • Salts of isophosphoramide mustard and analogs thereof
    Patent number: 9340563
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 17, 2016
    Assignee: ZIOPHARM Oncology, Inc.
    Inventors: John C. Amedio, Jr., Barbara Wallner, Philip B. Komarnitsky
  • Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
    Patent number: 9254298
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: February 9, 2016
    Assignee: ZIOPHARM Oncology, Inc.
    Inventors: Frank W. Waligora, John C. Amedio, Jr.
  • SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
    Publication number: 20150328238
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
    Type: Application
    Filed: July 23, 2015
    Publication date: November 19, 2015
    Inventors: Frank W. WALIGORA, John C. AMEDIO, JR.
  • Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
    Patent number: 9145431
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: September 29, 2015
    Assignee: ZIOPHARM Oncology, Inc.
    Inventors: Frank W. Waligora, John C. Amedio, Jr.
  • SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
    Publication number: 20140378704
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups; and A+ is an ammonium cation.
    Type: Application
    Filed: January 29, 2014
    Publication date: December 25, 2014
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: Frank W. WALIGORA, John C. AMEDIO, JR.
  • Salts of Isophosphoramide Mustard and Analogs Thereof
    Publication number: 20140194377
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Application
    Filed: November 6, 2013
    Publication date: July 10, 2014
    Applicant: ZIOPHARM ONCOLOGY, INC.
    Inventors: John C. AMEDIO, JR., Barbara WALLNER, Philip B. KOMARNITSKY
  • Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
    Patent number: 8664201
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups and A+ is an ammonium cation.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: March 4, 2014
    Assignee: Ziopharm Oncology, Inc.
    Inventors: Frank Walter Waligora, John C. Amedio
  • PHARMACEUTICAL FORMULATIONS OF INDIBULIN AND USES THEREOF
    Publication number: 20140004192
    Abstract: The present invention relates to pharmaceutical formulations that increase the solubility and bioavailability of indibulin, such as a spray-dried solid dispersion of indibulin with at least one matrix polymer. The invention further provides dosage formulations comprising the dispersion and processes for making the dispersion. The present invention also discloses a method of treating immune system based disorders, hyper-proliferative disorders, angiogenesis, malignancies, and neoplasms with the indibulin formulations disclosed herein.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 2, 2014
    Inventors: John C. Amedio, JR., Barbara Wallner, Marsha G. Marande
  • Salts of isophosphoramide mustard and analogs thereof
    Patent number: 8604007
    Abstract: Disclosed herein are crystalline compounds of formula (I) wherein A+ represents a hydroxylated aliphatic ammonium species; and X and Y independently represent leaving groups.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 10, 2013
    Assignee: Ziopharm Oncology, Inc.
    Inventors: John C. Amedio, Jr., Barbara P. Wallner, Philip B. Komarnitsky
  • PHARMACEUTICAL FORMULATIONS FOR INDIBULIN
    Publication number: 20120219597
    Abstract: In certain embodiments, the invention relates to pharmaceutical formulations of an indolyl-3-glyoxylic acid derivative or a pharmaceutically acceptable salt thereof, such as indibulin. Methods of preparing such formulations and methods of treatment using these formulations are also described.
    Type: Application
    Filed: September 1, 2010
    Publication date: August 30, 2012
    Applicant: ZIOPHARM Oncology, Inc.
    Inventor: John C. Amedio, JR.
  • Optically pure and enriched isomers of chelating ligands and contrast agents
    Patent number: 8048906
    Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 1, 2011
    Assignee: Catalyst Medical
    Inventors: John C. Amedio, Peter D. Caravan, Vincent Jacques, Kevin L. Zhou, Stuart Levy, Shirley Kalogeropoulos, Matthew Greenfield
  • SYNTHESIS AND FORMULATIONS OF SALTS OF ISOPHOSPHORAMIDE MUSTARD AND ANALOGS THEREOF
    Publication number: 20110212921
    Abstract: Disclosed herein are formulations and methods of manufacture of compounds of formula (E): wherein X and Y independently represent leaving groups and A+ is an ammonium cation.
    Type: Application
    Filed: July 30, 2009
    Publication date: September 1, 2011
    Applicant: ZIOPHARM ONOCOLOGY, INC.
    Inventors: Frank Walter Waligora, John C. Amedio