Abstract: The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.

Abstract: The invention provides compositions and methods for treating neoplastic disease, such as cancer, with an oncolytic virus, such as VSV. A carrier cell is used to target a diseased tissue, and to cloak the oncolytic virus from surveillance by the subject's immune system during a targeting interval. Following delivery of the virus to the target tissue, the lysis of the carrier cell, and of the target cell, by the oncolytic virus, promotes an adaptive tumouricidal immune response. A wide variety of disparate carrier cells may be used, in conjunction with a promiscuous oncolytic virus having broad tropism, in an approach which facilitates successive treatments in which a new carrier will not be susceptible to an adaptive immune response mounted against previously used carriers. The promiscuity of the virus also facilitates lysis of carrier cells and target cells that are allogenic or xenogenic.

Abstract: The present invention relates to therapeutic use of Myxoma virus. Myxomas virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

Abstract: The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon and can be used to treat diseases characterized by the presence of such cells, including cancer.

Abstract: The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus host diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cell harvests in the treatment of mammals including cancer patients, transplant recipients, and patients with autoimmune disease.

Abstract: A remote telemetry system utilizing dual communication pathways comprising low-cost remote communications devices operating on existing wire-based communications systems, wireless communications systems, and/or a combination thereof, to provide real-time reading and control of the remote telemetry units. A central controller directs the operation of the remote telemetry units and receives data from the remote telemetry units. The central controller is configured to utilize a conventional broadcast communications channel to transmit commands to individual remote telemetry units, each of which is assigned a unique identification code. Signals broadcast from the central controller are received at receivers associated with each remote telemetry unit, which performs a directed operation if a unique identification code included in the broadcast signal matches the identification code assigned to the remote telemetry unit.

Abstract: The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR−/−, STAT1−/− or both PKR−/− and STAT1−/−. The virus is selected from the group consisting of Rhabdovirus and picomavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.

Abstract: A one-way communications pathway between two integrated circuits comprises a VCSEL array of one or more light emitters on a first integrated circuit, coupled to a photo-detector array on a second integrated circuit. The photo-detector array comprises a number of detectors which is greater than the number of activated light emitters, such that light from each emitter is imaged onto one or more detectors. Each detector generates an electrical current signal when illuminated by the emitter light. Individual electrical current signals from multiple illuminated detectors are selected via switches, and routed through a summing junction. The resulting summed signal is amplified and converted to a digital output signal.

Abstract: The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR−/−, STAT1−/− or both PKR−/− and STAT1−/−. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.

Abstract: The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus host diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cell harvests in the treatment of mammals including cancer patients, transplant recipients, and patients with autoimmune disease.

Abstract: Viral gene constructs and modified viruses contain properties which permit them to replicate or have activity only in target cells such as diseased or otherwise infected cells.

Abstract: A remote telemetry system utilizing dual communication pathways comprising low-cost remote communications devices operating on existing wire-based communications systems, wireless communications systems, and/or a combination thereof, to provide real-time reading and control of the remote telemetry units. A central controller directs the operation of the remote telemetry units and receives data from the remote telemetry units. The central controller is configured to utilize a conventional broadcast communications channel to transmit commands to individual remote telemetry units, each of which is assigned a unique identification code. Signals broadcast from the central controller are received at receivers associated with each remote telemetry unit, which performs a directed operation if a unique identification code included in the broadcast signal matches the identification code assigned to the remote telemetry unit.

Abstract: The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating graft-versus host diseases, and autoimmune cells. The subject invention also relates to the purging of undesirable cells from bone marrow or peripheral blood cell harvests in the treatment of mammals including cancer patients, transplant recipients, and patients with autoimmune disease.

Abstract: A user input device is disclosed adapting the electronic components of a time-domain reflectometry material level sensor to replace traditional user input devices such as push-buttons, control knobs, and variable sliders. An electrical conductor is arrayed beneath an input panel, such that when a high permittivity or high conductivity material is placed in proximity to the conductor, the characteristic impedance of the conductor is altered at that point, reflecting electronic pulses transmitted through the conductor. The reflected electronic pulse is received by the associated electronics, and the position of the material along the conductor subsequently determined. By segmenting the conductor into virtual regions, each corresponding to an individual "button", discrete input may be received by the device based upon the placement of the material within specific virtual regions.

Abstract: A computer-controlled overhead conveyor system is provided wherein all conveyor vehicles substantially continually communicate with a control system to be routed through the track network. The track is conceptually divided into zones each identified by an optically read marker; and the vehicles include scanners for reading the markers as the vehicles traverse the track. The marker information is communicated to the control system which controls track switches and vehicle velocities to prevent collisions and to direct the vehicles to desired destinations. Preferably, each vehicle includes a circuit for indicating the weight of the load transported thereby; and the control system calculates running totals of material weight moved--for example by material type or by track station. Further preferably, the control system controls the acceleration/deceleration of each vehicle in a manner dependent on the material type and weight to effect the maximum vehicle speeds while preventing damage to vehicle loads.

Abstract: A meter disconnect adaptor for assembly into a residential electric meter socket. The adaptor has a base with a peripheral configuration which allows it to be used with either a ringless type of meter box, or in a ring type of mounting, and has blade simulating members extending from one side of the base and resilient fingers extending from the other side of the base for receiving contact blades of the electric meter. In one embodiment of the invention the adaptor has a group of resilient fingers arranged to allow assembly of the meter therein in any one of a number of orientations.