Patents by Inventor John C. Bischof
John C. Bischof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230125964Abstract: Methods for cryopreservation of biological samples are provided. The biological samples are sub-millimeter or millimeter scale biological materials. The biological samples are pancreatic islets and stem cell derived islets. Methods for cryopreservation of islets using cryomesh and multi-step loading and unloading of CPA cocktails are provided. Methods disclosed result in vitrified and rewarmed islets with high recovery, viability and functionality. Methods are scalable for high throughput production of large amounts of vitrified and rewarmed islets for use in therapeutic transplantation.Type: ApplicationFiled: October 20, 2022Publication date: April 27, 2023Inventors: Li Zhan, Joseph Sushil Rao, Zonghu Han, Nikhil Sethia, Michael L. Etheridge, Cari S. Dutcher, Erik B. Finger, John C. Bischof
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Publication number: 20230025400Abstract: A system includes a placement head with at least one printing nozzle configured to pick up and detachably hold at least one biological organism; an image acquisition system including a visual inspection system configured to identify at least one target biological organism to be picked up by the printing nozzle of the placement head in a first location, and identify at least one second location for deposit of the at least one target biological organism, wherein the first location is different from the at least one second location; and a robotic motion system that moves the placement head, based on input from the visual inspection system and a distance identification system, from the first location to the at least one second location, such that the placement head deposits the target biological organism at the at least one second location.Type: ApplicationFiled: July 20, 2022Publication date: January 26, 2023Inventors: Michael C. McAlpine, Guebum Han, John C. Bischof, Kanav Khosla, Kieran T. Smith
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Publication number: 20220132835Abstract: This disclosure describes compositions and methods related to cryoprotection of biomaterial. Generally, the cryoprotective composition includes a cryoprotective agent and magnetic nanoparticles effective for thawing a cryopreserved specimen comprising biomaterial with minimal biomaterial damage. In some embodiments, the composition is effective for thawing a cryopreserved specimen having a minimum dimension of 0.1 mm. Generally, the method includes obtaining a biomaterial cryopreserved with a cryoprotective composition as summarized above, then subjecting the cryopreserved biomaterial to electromagnetic energy of an intensity sufficient to excite the magnetic nanoparticles and thaw the biomaterial.Type: ApplicationFiled: January 19, 2022Publication date: May 5, 2022Inventors: John C. Bischof, Michael L. Etheridge, Jeunghwan Choi
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Publication number: 20220071196Abstract: A method of preserving tissue includes loading the tissue with a solution with a cryoprotective agent and susceptor particles; freezing the tissue; thawing the tissue; and after freezing and thawing, further processing the tissue. Further processing may include slicing the tissue or digesting the tissue and recovering isolated cells from the digested tissue. The tissue may include at least a portion of an organ. The tissue may include a whole organ. The loading of the solution may be done via the vasculature of the organ. The tissue may be thawed using inductive heating. The susceptor particles may include nanoparticles.Type: ApplicationFiled: January 16, 2020Publication date: March 10, 2022Inventors: Charles Y. Lee, John C. Bischof, Erik B. Finger, Anirudh Sharma
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Patent number: 11141209Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.Type: GrantFiled: September 10, 2018Date of Patent: October 12, 2021Inventors: Jean-Pierre Lalonde, Regina E. Groves, Timothy G. Laske, Paul A. Iaizzo, John C. Bischof
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Patent number: 10816492Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.Type: GrantFiled: May 2, 2017Date of Patent: October 27, 2020Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
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Patent number: 10725033Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.Type: GrantFiled: November 2, 2017Date of Patent: July 28, 2020Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
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Publication number: 20190105094Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.Type: ApplicationFiled: October 5, 2018Publication date: April 11, 2019Inventors: Samira M. Azarin, Francisco Pelaez, Navid Manuchehrabadi, John C. Bischof
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Publication number: 20190008572Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.Type: ApplicationFiled: September 10, 2018Publication date: January 10, 2019Inventors: Jean-Pierre Lalonde, Regina E. Groves, Timothy G. Laske, Paul A. Iaizzo, John C. Bischof
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Patent number: 10098685Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.Type: GrantFiled: February 27, 2014Date of Patent: October 16, 2018Assignee: Medtronic CryoCath LPInventors: Jean-Pierre Lalonde, Regina E. Groves, Timothy G. Laske, Paul A. Iaizzo, John C. Bischof
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Publication number: 20180128827Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.Type: ApplicationFiled: November 2, 2017Publication date: May 10, 2018Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
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Patent number: 9851316Abstract: A sensing system uses three-omega sensing to determine a spatial profile of thermal property within a sample. The sensing system electrically powers a lossy electrical conductor at different driving frequencies. The different driving frequencies produce different penetration depths within the sample. The sensing system takes multiple measurements of thermal property at the different driving frequencies. Each measurement is associated with a different penetration depth, and therefore is averaged over a differently-sized volume within the sample. The sensing system performs a fit on the multiple measurements of material thermal property versus material geometry. If one of thermal property or geometry is known beforehand, then the fit can determine the other. The lossy electrical conductor can be formed on a polymeric flexible membrane, on a probe that can be placed at a suitable location in a patient's body, and/or directly onto a heating or cooling element.Type: GrantFiled: November 5, 2014Date of Patent: December 26, 2017Assignee: Regents of the University of MinnesotaInventors: Sean D. Lubner, Jeunghwan Choi, Harishankar Natesan, Christopher E. Dames, John C. Bischof
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Publication number: 20170234817Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.Type: ApplicationFiled: May 2, 2017Publication date: August 17, 2017Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
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Patent number: 9651508Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. The thermal contrast reader includes housing having an opening to receive the test strip at a test location, an energy source directed at the test location and a heat sensor directed at the test location. The heat sensor is configured to sense heating of the test strip upon activation of the heat source at the test location, if the target analyte is present in the sample. The heat sensor can provide sensor output using diagnostic circuitry coupled to the sensor output and configured to provide a diagnostic output. The diagnostic output can indicate the diagnostic condition of the patient as a function of the sensor output. The present disclosure also includes methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader.Type: GrantFiled: January 30, 2013Date of Patent: May 16, 2017Assignee: Regents of the University of MinnesotaInventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin
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Publication number: 20160015025Abstract: This disclosure describes compositions and methods related to cryoprotection of biomaterial. Generally, the cryoprotective composition includes a cryoprotective agent and magnetic nanoparticles effective for thawing a cryopreserved specimen comprising biomaterial with minimal biomaterial damage. In some embodiments, the composition is effective for thawing a cryopreserved specimen having a minimum dimension of 0.1 mm. Generally, the method includes obtaining a biomaterial cryopreserved with a cryoprotective composition as summarized above, then subjecting the cryopreserved biomaterial to electromagnetic energy of an intensity sufficient to excite the magnetic nanoparticles and thaw the biomaterial.Type: ApplicationFiled: March 14, 2014Publication date: January 21, 2016Inventors: John C. BISCHOF, Michael L. ETHERIDGE, Jeunghwan CHOI
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Publication number: 20150127294Abstract: A sensing system uses three-omega sensing to determine a spatial profile of thermal property within a sample. The sensing system electrically powers a lossy electrical conductor at different driving frequencies. The different driving frequencies produce different penetration depths within the sample. The sensing system takes multiple measurements of thermal property at the different driving frequencies. Each measurement is associated with a different penetration depth, and therefore is averaged over a differently-sized volume within the sample. The sensing system performs a fit on the multiple measurements of material thermal property versus material geometry. If one of thermal property or geometry is known beforehand, then the fit can determine the other. The lossy electrical conductor can be formed on a polymeric flexible membrane, on a probe that can be placed at a suitable location in a patient's body, and/or directly onto a heating or cooling element.Type: ApplicationFiled: November 5, 2014Publication date: May 7, 2015Inventors: Sean D. Lubner, Jeunghwan Choi, Harishankar Natesan, Christopher E. Dames, John C. Bischof
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Publication number: 20150119868Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.Type: ApplicationFiled: February 27, 2014Publication date: April 30, 2015Applicant: MEDTRONIC CRYOCATH LPInventors: Jean-Pierre Lalonde, Regina E. Groves, Timothy G. Laske, Paul A. Iaizzo, John C. Bischof
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Publication number: 20140377770Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. The thermal contrast reader includes housing having an opening to receive the test strip at a test location, an energy source directed at the test location and a heat sensor directed at the test location. The heat sensor is configured to sense heating of the test strip upon activation of the heat source at the test location, if the target analyte is present in the sample. The heat sensor can provide sensor output using diagnostic circuitry coupled to the sensor output and configured to provide a diagnostic output. The diagnostic output can indicate the diagnostic condition of the patient as a function of the sensor output. The present disclosure also includes methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader.Type: ApplicationFiled: January 30, 2013Publication date: December 25, 2014Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin
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Patent number: 7344531Abstract: Methods, compositions, and systems useful to enhance a thermal surgical procedure are described. Compositions include at least one compound effective to induce an inflammatory response in biological material identified to undergo a thermal surgical procedure. Methods and systems include providing compositions of the invention to biological materials and treating biological materials with an inflammation inducing composition for a time, amount, and type effective to induce inflammation in at least a portion of the biological material.Type: GrantFiled: November 7, 2005Date of Patent: March 18, 2008Assignee: Regents of the University of MinnesotaInventors: John C. Bischof, John D. Belcher, Gregory M. Vercellotti
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Patent number: 7344530Abstract: Methods, compositions, and systems useful to enhance a thermal surgical procedure are described. Compositions include at least one compound effective to induce an inflammatory response in biological material identified to undergo a thermal surgical procedure. Methods and systems include providing compositions of the invention to biological materials and treating biological materials with an inflammation inducing composition for a time, amount, and type effective to induce inflammation in at least a portion of the biological material.Type: GrantFiled: March 26, 2004Date of Patent: March 18, 2008Assignee: Regents of the University of MinnesotaInventors: John C. Bischof, John D. Belcher, Gregory M. Vercellotti