Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: Genes encoding an apoptosis-induced eukaryotic initiation Factor-5A (eIF-5A) and an apoptosis-induced deoxyhypusine synthase (DHS), whose expressions are induced by the onset of apoptosis, are identified. The DHS gene and the eIF-5A gene, alone or in combination, as well as inhibitors of the DHS reaction, are used to modulate apoptosis in animals and humans. For example, modulation of apoptosis in cells of animals and humans is achieved by introduction of a gene or gene fragment encoding apoptosis-induced eIF-5A, apoptosis-induced DHS, or both into the animal or human cell in antisense orientation.

Abstract: A file storage device has an exterior shell with an outer surface and an openable panel defining part of the exterior shell. The openable panel has a bottom edge, a forward facing surface, and a rear facing surface. The openable panel is pivotable about its bottom edge outward from the exterior shell between a retracted condition at which the forward facing surface is generally flush with the outer surface of the exterior shell and an open condition away from the outer surface of the exterior shell. A file support structure has a file storage area, an open top for insertion, access to, and removal of files from the file storage area, and a file suspension device provided to suspend files within the file storage area. The file support structure is disposed adjacent to the rear facing surface of the openable panel and is movable in concert with the openable panel. The open top is accessible when the openable panel is in the open condition.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Abstract: The preferred field assembly includes a field shell of generally T-shaped radial cross-section and molded of powdered metal, a plastic bobbin for supporting a multiple turn winding, and a plastic bobbin ring which covers part of the field shell and which helps hold the bobbin in assembled relation with the field shell. The bobbin is formed with a terminal block for supporting electrical leads which extend along grooves in the outboard face of one flange of the bobbin and which, together with the end portions of the winding, extend into potting cavities in the outboard face of the bobbin flange. The bobbin ring includes a cap which interfits with the terminal block to retain the leads. Various embodiments of field shells, bobbins and bobbin rings are disclosed.

Abstract: This application deals with apparatus for calibrating an automated machining apparatus. The calibration apparatus comprises a tool probe and a system accuracy check gauge rigidly fixed to the workpiece loading mechanism of the machining apparatus. This arrangement allows variations in the locations of the cutting edges of the tools used in the machining apparatus to be taken into account in the machining operation and also allows checking of the dimensional and positional accuracy of the machining apparatus against a precisely known reference.

Abstract: One pair of actuating piston and cylinder assemblies are operatively connected to the polish or sucker rod of the pump and are extended or retracted by hydraulic fluid. A further pair of piston and cylinder assemblies are operatively connected to the polish rod and are operatively connected on the underside thereof to an accumulator that includes an inert gas over oil with the gas being supplied under adjustable control conditions from a cylinder or source of high pressure gas so that these further pair of piston and cylinder assemblies counteract the weight of the pump system. On the downstroke, pressure is supplied to the upper sides of all four piston and cylinder assemblies with the two further piston and cylinder assemblies supporting the weight via the accumulator.

Abstract: A self-tensioning wire reel comprises two flanges threaded together such that, when a brake shoe applies a braking force to one flange, the other flange is free to continue rotating. This rotation on the threaded hubs brings the flanges closer together, exerting a lateral force on the wire coil therebetween and thus keeping the coil sufficiently tight to prevent binding during the unreeling operation. The brake shoe is a resilient cylindrical disk applied to the outer rim of one flange when tension is relieved on the wire. The tightness of fit between the disk brake and the shaft upon which it rotates controls the frictional braking force.