Patents by Inventor John C. Castle

John C. Castle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
    Patent number: 7150969
    Abstract: The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID NO 3. The amino acid sequence of ACC2sv1 is provided by SEQ ID NO 4. The present invention also provides methods for using ACC2sv1 polynucleotides and proteins to screen for compounds that bind to ACC2sv1.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: December 19, 2006
    Assignee: Rosetta Inpharmatics LLC
    Inventors: Zhengyan Kan, Philip W. Garrett-Engele, Christopher D. Armour, Christopher K. Raymond, John C. Castle
  • Alternatively spliced isoforms of cysteine protease cathepsin K (CTSK)
    Publication number: 20040224341
    Abstract: The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of cysteine protease cathepsin K (CTSK). The polynucleotide sequences of CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 1 and SEQ ID NO 3, respectively. The amino acid sequences for CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 2 and SEQ ID NO 4, respectively. The present invention also provides methods for using CTSKsv1.1 and CTSKsv1.2 polynucleotides and proteins to screen for compounds that bind to CTSKsv1.1 and CTSKsv1.2, respectively.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 11, 2004
    Inventors: Christopher D. Armour, John C. Castle, Philip W. Garrett-Engele, Jason M. Johnson, Zhengyan Kan, Patrick M. Loerch
  • Alternatively spliced isoforms of histone deacetylase 3 (HDAC3)
    Publication number: 20040197888
    Abstract: The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of histone deacetylase 3 (HDAC3). The polynucleotide sequences of HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, HDAC3sv4, HDAC3sv5, and HDAC3sv6 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9, SEQ ID NO 20, and SEQ ID NO 21, respectively. The amino acid sequences for HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 are provided by SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The present invention also provides methods for using HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, and HDAC3sv4 polynucleotides and proteins to screen for compounds that bind to HDAC3sv1.1, HDAC3sv1.2, HDAC3sv2, HDAC3sv3, or HDAC3sv4, respectively.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 7, 2004
    Inventors: Christopher D. Armour, Patrick M. Loerch, John C. Castle, Jason M. Johnson
  • Splice variant isoforms of human calcium channel CACNA1B
    Publication number: 20040081988
    Abstract: The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of calcium channel &agr;1B subunit (CACNA1B). The polynucleotide sequence of CACNA1Bsv1 is provided by SEQ ID NO 1 and the polynucleotide sequence of CACNA1Bsv2 is provided by SEQ ID NO 3. The amino acid sequence for CACNA1Bsv1 is provided by SEQ ID NO 2 and the amino acid sequence for CACNA1Bsv1 is provided by SEQ ID NO 4. The present invention also provides methods for using CACNAlBsv1 and CACNA1Bsv2 polynucleotides and the respective proteins to screen for compounds that bind to CACNA1Bsv1 and CACNA1Bsv2.
    Type: Application
    Filed: July 25, 2003
    Publication date: April 29, 2004
    Inventors: Jason M. Johnson, Christopher D. Armour, John C. Castle