Patents by Inventor John C. FREEDMAN

John C. FREEDMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS
    Publication number: 20230338444
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Application
    Filed: June 15, 2023
    Publication date: October 26, 2023
    Applicant: Krystal Biotech, Inc.
    Inventors: Suma KRISHNAN, Pooja AGARWAL, John C. FREEDMAN, Mark E. O'MALLEY, Lauren K. REGULA
  • Compositions and methods for the treatment of autosomal recessive congenital ichthyosis
    Patent number: 11717547
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: August 8, 2023
    Assignee: Krystal Biotech, Inc.
    Inventors: Suma Krishnan, Pooja Agarwal, John C. Freedman, Mark E. O'Malley, Lauren K. Regula
  • COMPOSITIONS AND METHODS FOR TREATMENT OF NETHERTON SYNDROME
    Publication number: 20230218691
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a polypeptide; viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Application
    Filed: March 22, 2023
    Publication date: July 13, 2023
    Applicant: Krystal Biotech, Inc.
    Inventors: Pooja AGARWAL, Suma KRISHNAN, John C. FREEDMAN
  • Compositions and methods for the treatment of Netherton Syndrome
    Patent number: 11642384
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: May 9, 2023
    Assignee: Krystal Biotech, Inc.
    Inventors: Pooja Agarwal, Suma Krishnan, John C. Freedman
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF NETHERTON SYNDROME
    Publication number: 20220409685
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.
    Type: Application
    Filed: July 22, 2022
    Publication date: December 29, 2022
    Applicant: Krystal Biotech, Inc.
    Inventors: Pooja AGARWAL, Suma KRISHNAN, John C. FREEDMAN
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS
    Publication number: 20200197456
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Application
    Filed: January 3, 2020
    Publication date: June 25, 2020
    Applicant: Krystal Biotech, Inc.
    Inventors: Suma KRISHNAN, Pooja AGARWAL, John C. FREEDMAN, Mark E. O'MALLEY, Lauren K. REGULA
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF NETHERTON SYNDROME
    Publication number: 20200093874
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 26, 2020
    Applicant: Krystal Biotech, Inc.
    Inventors: Pooja AGARWAL, Suma KRISHNAN, John C. FREEDMAN
  • Compositions and methods for the treatment of autosomal recessive congenital ichthyosis
    Patent number: 10525090
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 7, 2020
    Assignee: Krystal Biotech, Inc.
    Inventors: Suma Krishnan, Pooja Agarwal, John C. Freedman, Mark E. O'Malley, Lauren K. Regula
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOSOMAL RECESSIVE CONGENITAL ICHTHYOSIS
    Publication number: 20190314430
    Abstract: The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
    Type: Application
    Filed: April 11, 2019
    Publication date: October 17, 2019
    Applicant: Krystal Biotech, Inc.
    Inventors: Suma KRISHNAN, Pooja AGARWAL, John C. FREEDMAN, Mark E. O'MALLEY, Lauren K. REGULA