Patents by Inventor John C. Gebler

John C. Gebler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Destructible surfactants and uses thereof
    Patent number: 9598716
    Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: March 21, 2017
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying Q. Yu, Peter J. Lee, Elizabeth K. Kane
  • DESTRUCTIBLE SURFACTANTS AND USES THEREOF
    Publication number: 20140065651
    Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: Edouard S. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying Q. Yu, Peter J. Lee, Elizabeth K. Brown
  • Destructible surfactants and uses thereof
    Patent number: 8580533
    Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: November 12, 2013
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S. P. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying-Qing Yu, Peter Jeng-Jong Lee, Elizabeth K. Brown
  • Apparatus and methods for mass-spectrometric directed purification of biopolymers
    Patent number: 8153009
    Abstract: A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time-varying composition through the conduit (110). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: April 10, 2012
    Assignee: Waters Technologies Corporation
    Inventors: Martin Gilar, John C. Gebler, Fang Xia
  • Sample preparation plate for mass spectrometry
    Patent number: 7888637
    Abstract: Disclosed herein is a sample preparation plate used to prepare a sample for mass spectrometry. In particular, a sample plate used to concentrate a sample as well as remove contaminants from the sample while providing easy manipulation of small liquid droplets on a surface with minimal sample loss.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: February 15, 2011
    Assignee: Waters Technologies Corporation
    Inventors: Jeffrey W. Finch, John C. Gebler, Santiago Vazquez
  • Apparatus and Methods for Mass-Spectrometric Directed Purification of Biopolymers
    Publication number: 20080283739
    Abstract: A method for extracting at least one target compound from a sample includes injecting an overloaded amount of the sample into a chromatographic conduit (110), and flowing a solvent having a time-varying composition through the conduit (110). An apparatus for extracting at least one target compound from a sample includes a chromatography module, a mass-spectrometry module in fluid communication with the chromatography module to receive a portion of an eluent from the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 20, 2008
    Applicant: WATERS INVESTMENTS LIMITED
    Inventors: Martin Gilar, John C. Gebler, Fang Xia