Patents by Inventor John C. Gore

John C. Gore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9747490
    Abstract: In the various embodiments, cell size imaging is performed using a method that relies upon the acquisition of gradient echo and spin echo data during contrast agent (CA) passage through tissue and estimation of “perturber” size using the ratio of ?R2* and ?R2. When measured at CA equilibrium, the magnetic field perturbations, and associated MRI signal changes, are determined by the cellular features and not the vasculature. Thus, in cell size imaging the cells act as the perturbers.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: August 29, 2017
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Christopher Chad Quarles, John C. Gore, Natenael B. Semmineh
  • Publication number: 20160125224
    Abstract: In the various embodiments, cell size imaging is performed using a method that relies upon the acquisition of gradient echo and spin echo data during contrast agent (CA) passage through tissue and estimation of “perturber” size using the ratio of ?R2* and ?R2. When measured at CA equilibrium, the magnetic field perturbations, and associated MRI signal changes, are determined by the cellular features and not the vasculature. Thus, in cell size imaging the cells act as the perturbers.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Christopher Chad Quarles, John C. Gore, Natenael B. Semmineh
  • Patent number: 9266847
    Abstract: Embodiments of the present disclosure provide for a compound, methods of making a compound, a probe, methods of making a probe, pharmaceutical compositions including a probe or a compound, methods of using a probe, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a disease (e.g., cancer, diseases caused by inflammation (e.g., arthritis, cardiovascular disease, and the like)), and the like, and/or related biological events using a probe, kit for imaging, diagnosing, localizing, monitoring, and/or assessing a disease, and/or related biological events, using a probe, and the like.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: February 23, 2016
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Wellington Pham, Donald D. Nolting, John C. Gore
  • Publication number: 20140134107
    Abstract: Embodiments of the present disclosure provide for a compound, methods of making a compound, a probe, methods of making a probe, pharmaceutical compositions including a probe or a compound, methods of using a probe, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a disease (e.g., cancer, diseases caused by inflammation (e.g., arthritis, cardiovascular disease, and the like)), and the like, and/or related biological events using a probe, kit for imaging, diagnosing, localizing, monitoring, and/or assessing a disease, and/or related biological events, using a probe, and the like.
    Type: Application
    Filed: November 7, 2013
    Publication date: May 15, 2014
    Inventors: Wellington Pham, Donald D. Nolting, John C. Gore
  • Publication number: 20120164635
    Abstract: A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino-carboxylic acid group, amido group, amino-amido group, and methods of use related to imaging.
    Type: Application
    Filed: March 6, 2012
    Publication date: June 28, 2012
    Inventors: Wellington Pham, John C. Gore
  • Patent number: 8168804
    Abstract: A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino-carboxylic acid group, amido group, amino-amido group, and methods of use related to imaging.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: May 1, 2012
    Assignee: Vanderbilt University
    Inventors: Wellington Pham, John C Gore
  • Patent number: 7777488
    Abstract: In another aspect, the present invention relates to a method for NMR measurements of an arbitrarily shaped region of interest of a living subject. In one embodiment, the method comprises the steps of applying a broad bandwidth of RF pulses to the arbitrarily shaped region of interest to obtain a corresponding spectrum, wherein substantially entire range of chemical shifts in the spectrum is excited from the arbitrarily shaped region of interest, interleaving a plurality of radial k-lines in radial k-space per excitation with non-selective refocusing pulses and obtaining spatial localization for the spectrum of the arbitrarily shaped region of interest.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: August 17, 2010
    Assignee: Vanderbilt University
    Inventors: John C. Gore, Qin Qin, Robin A. De Graaf
  • Publication number: 20090029405
    Abstract: A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino-carboxylic acid group, amido group, amino-amido group, and methods of use related to imaging.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 29, 2009
    Inventors: Wellington Pham, John C. Gore
  • Publication number: 20090021254
    Abstract: In another aspect, the present invention relates to a method for NMR measurements of an arbitrarily shaped region of interest of a living subject. In one embodiment, the method comprises the steps of applying a broad bandwidth of RF pulses to the arbitrarily shaped region of interest to obtain a corresponding spectrum, wherein substantially entire range of chemical shifts in the spectrum is excited from the arbitrarily shaped region of interest, interleaving a plurality of radial k-lines in radial k-space per excitation with non-selective refocusing pulses and obtaining spatial localization for the spectrum of the arbitrarily shaped region of interest.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: VANDERBILT UNIVERSITY
    Inventors: John C. GORE, Qin QIN, Robin A. DE GRAAF
  • Patent number: 6218673
    Abstract: An optical scanner gives three dimensional dosimetric data by scanning, with at least one light beam, a translucent medium exhibiting optical properties which change upon receipt of radiant energy representing a dose distribution of the energy. At least one detector is employed to gather data indicative of changes in the optical properties of the medium after scanning from multiple directions to provide a representation of the optical properties in sections through the medium. Typical optical properties measured include optical density, light scattering, emitted light intensities, and combinations thereof.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: April 17, 2001
    Assignee: Yale University
    Inventors: John C. Gore, Marek J. Maryanski, Robert J. Schulz
  • Patent number: 5633584
    Abstract: A visible and/or MRI visualizable permanent image is formed in a gel in a container which maintains the gel a dimensionally stable shape, which gel contains uniformly dispersed therein in storage stable form at least one radiant energy, e.g., ionizing radiation, or mechanical, e.g., ultrasonic or sonic shock wave, polymerizable monomer in a concentration effective to form a polymer in the gel which alters the NMR relaxation time of the solvent in any area thereof in which the polymer is formed, e.g.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: May 27, 1997
    Assignee: Yale University
    Inventors: Marek J. Maryanskl, John C. Gore, Robert Schulz