Patents by Inventor John C. Graham

John C. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190314490
    Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Inventors: John R. MASCOLA, Jeffrey C. BOYINGTON, Hadi M. YASSINE, Peter D. KWONG, Barney S. GRAHAM, Masaru KANEKIYO
  • Patent number: 10415484
    Abstract: An example engine control system may include an oxygen intake sensor; a fuel delivery device to control a rate of fuel delivery to the engine combustor; a combustor pressure sensor; a combustor temperature sensor; and a controller to receive at least one of an oxygen intake signal, a combustor pressure signal, and a combustor temperature signal; determine at least one of a reference specific fuel consumption (SFC) of the engine or a reference amount of a respective exhaust gas of a plurality of exhaust gases based on the oxygen signal, the pressure signal, and the temperature signal; compare at least one of the reference SFC or the reference amount of a respective exhaust gas to a respective threshold value; and control the fuel delivery device to control the rate of fuel delivery based on the comparison.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: September 17, 2019
    Assignee: Rolls-Royce Corporation
    Inventors: Kenneth L. Graham, Robert C. Dalley, John Joseph Costello
  • Patent number: 10363301
    Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: July 30, 2019
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: John R. Mascola, Jeffrey C. Boyington, Hadi M. Yassine, Peter D. Kwong, Barney S. Graham, Masaru Kanekiyo
  • Patent number: 10356204
    Abstract: An application based hardware identifier is generated for an application on a device. The application based hardware identifier is generated based on both information describing the application and information describing one or more hardware components of the device. The application based hardware identifier can also optionally be based on an identifier of a user of the device. The application based hardware identifier can be provided by the application to a service provider, allowing the service provider to associate the application based hardware identifier with a particular user or user account. However, as the application based hardware identifier is based on the application information, different applications on the same device will have different application based hardware identifiers. The application based hardware identifier thus helps maintain privacy by preventing tracking of the device across different applications.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: July 16, 2019
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: John A. M. Hazen, Stan D. Pennington, Sermet Iskin, Robin C. Speed, John M. Sheehan, Scott B. Graham
  • Publication number: 20190192651
    Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
    Type: Application
    Filed: September 1, 2017
    Publication date: June 27, 2019
    Inventors: Jeffrey C. BOYINGTON, Barney S. GRAHAM, John R. MASCOLA, Hadi M. YASSINE, Kizzmekia S. CORBETT, Syed M. MOIN, Lingshu WANG, Masaru KANEKIYO
  • Patent number: 7487354
    Abstract: Preparing a document for transmission over a network in a manner that increases the security of URLs included in the document. A server accesses a document that contains a number of URLs. For one or more of those URLs, the server calculates a digital signature that is unique to the intended recipient client, or unique to the user of the client. The server then modifies each of those URLs by including the digital signature in the URL. The document with the modified URLs in then transmitted over the network to the client. Thus, even if a sensitive URL is discovered, that modified URL is unique to the client only or to the user of the client only. Therefore, the damage that may be caused by an unauthorized user is limited to just that client or user.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: February 3, 2009
    Assignee: Microsoft Corporation
    Inventors: Jay D. Logue, John C. Graham
  • Patent number: 7089304
    Abstract: Methods, systems and computer program products for tracking a client's usage of one or more services provided by one or more servers. A client generates and sends one or more metering packets to a census service. Each metering packet includes a time element indicating the client's usage of the one or more services. The time element may include a charged time portion and a free time portion. An authentication element may be included with each metering packet so that the census service can determine whether or not a given metering packet is genuine. A login service communicates to the client whether or not usage should be tracked and indicates a time interval to expire between subsequent metering packets. A session identifier in each metering packet allows multiple sessions to be tracked simultaneously. Upon receiving metering packets, the census service discards redundant metering packets and updates a usage database accordingly.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: August 8, 2006
    Assignee: Microsoft Corporation
    Inventor: John C. Graham
  • Patent number: 6847971
    Abstract: A lightweight row transfer protocol is described that can be easily handled by thin clients, such as JAVA™ applications using CORBA. The lightweight row transfer protocol serves to reduce bandwidth requirements by applying compression techniques to reduce the number of column lengths in a “result set” of rows that are transmitted from one computer to another.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: January 25, 2005
    Assignee: Oracle International Corporation
    Inventors: Sukanya Balaraman, Alan Robert Downing, John C. Graham, Lewis S. Kaplan, Benny Souder, Harry Sun
  • Patent number: 6532479
    Abstract: Replication for front office automation involves the use of snapshots that are instantiated on laptops, in which refreshing the snapshots is driven from a master site with a high-performance protocol. All of the necessary snapshot metadata for performing the snapshot refreshes is stored at the master site, so that the laptop only needs to send a single refresh request. In response to the refresh request, the master site reconciles the differences between the master tables and the laptop's snapshots and transmits the differences to the laptop, reducing the necessary network traffic for updating a snapshot to a single round trip.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: March 11, 2003
    Assignee: Oracle Corp.
    Inventors: Benny Souder, Alan Robert Downing, Harry Sun, Alan J. Demers, James William Stamos, John C. Graham, Curtis Elsbernd, Mahesh Subramaniam, Wayne E. Smith
  • Publication number: 20030046409
    Abstract: Methods, systems and computer program products for tracking a client's usage of one or more services provided by one or more servers. A client generates and sends one or more metering packets to a census service. Each metering packet includes a time element indicating the client's usage of the one or more services. The time element may include a charged time portion and a free time portion. An authentication element may be included with each metering packet so that the census service can determine whether or not a given metering packet is genuine. A login service communicates to the client whether or not usage should be tracked and indicates a time interval to expire between subsequent metering packets. A session identifier in each metering packet allows multiple sessions to be tracked simultaneously. Upon receiving metering packets, the census service discards redundant metering packets and updates a usage database accordingly.
    Type: Application
    Filed: August 30, 2001
    Publication date: March 6, 2003
    Inventor: John C. Graham
  • Publication number: 20030009431
    Abstract: Replication for front office automation involves the use of snapshots that are instantiated on laptops, in which refreshing the snapshots is driven from a master site with a high-performance protocol. All of the necessary snapshot metadata for performing the snapshot refreshes is stored at the master site, so that the laptop only needs to send a single refresh request. In response to the refresh request, the master site reconciles the differences between the master tables and the laptop's snapshots and transmits the differences to the laptop, reducing the necessary network traffic for updating a snapshot to a single round trip.
    Type: Application
    Filed: May 28, 1999
    Publication date: January 9, 2003
    Inventors: BENNY SOUDER, ALAN ROBERT DOWNING, HARRY SUN, ALAN J. DEMERS, JAMES WILLIAM STAMOS, JOHN C. GRAHAM, CURTIS ELSBERND, MAHESH SUBRAMANIAM, WAYNE E. SMITH
  • Publication number: 20020174341
    Abstract: Preparing a document for transmission over a network in a manner that increases the security of URLs included in the document. A server accesses a document that contains a number of URLs. For one or more of those URLs, the server calculates a digital signature that is unique to the intended recipient client, or unique to the user of the client. The server then modifies each of those URLs by including the digital signature in the URL. The document with the modified URLs in then transmitted over the network to the client. Thus, even if a sensitive URL is discovered, that modified URL is unique to the client only or to the user of the client only. Therefore, the damage that may be caused by an unauthorized user is limited to just that client or user.
    Type: Application
    Filed: May 18, 2001
    Publication date: November 21, 2002
    Inventors: Jay D. Logue, John C. Graham
  • Patent number: 6035702
    Abstract: A drain plug sensor for determining whether a drain plug is inserted into a drain hole of a watercraft is provided. In a preferred embodiment, a reed switch for sensing a magnetic field is threadably mated with a receiver at one end thereof. The receiver and reed switch are emplaced into the drain hole. The drain plug, which is capable of being inserted into another end of the receiver, is formed together with a samarium cobalt magnet such that a magnetic field is created and emanated therefrom. In this manner, whenever the drain plug is inserted into the receiver, the reed switch detects the presence of the magnetic field. Conversely, whenever the drain plug is not inserted into the drain hole, no magnetic field is detected. Regardless of whether the drain plug is inserted into the drain hole, an indication is supplied to a user to alert the user as to whether the drain hole is operational.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: March 14, 2000
    Inventor: John C. Graham
  • Patent number: 4183796
    Abstract: A radiation curable oligomer which cures to provide a combination of improved elongation and tensile strength is constituted by a selected hydroxy functional polyester having its active hydrogen atoms end-capped by reaction with ethylenically unsaturated monoisocyanate. This polyester is the reaction product of one mole of tris (2-hydroxyethyl) isocyanurate with three moles of saturated dicarboxylic acid and three moles of diol, these proportions being variable within the limits of .+-.20%, the polyester reaction product having an acid value of less than 20, preferably less than 5, and providing hydroxyl-terminated branches having an average length corresponding to a calculated molecular weight of 100-1500.
    Type: Grant
    Filed: February 9, 1978
    Date of Patent: January 15, 1980
    Assignee: DeSoto, Inc.
    Inventors: Robert E. Ansel, John C. Graham
  • Patent number: 4031147
    Abstract: A process for the production of nuclear chlorinated alkylbenzenes comprises reacting, in the liquid phase, an alkylbenzene with chlorine in the presence of a Lewis acid catalyst and a co-catalyst comprising a thianthrene compound or mixture of thianthrene compounds characterized by the formula: ##STR1## where each n is 0 to 1, and each x is hydrogen or an electron-withdrawing substituent with the proviso that at least one x is an electron withdrawing substituent. The monochlorinated alkylbenzene products prepared in this manner are characterized by a desirably low ratio of ortho to para isomer.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: June 21, 1977
    Assignee: Hooker Chemicals & Plastics Corporation
    Inventor: John C. Graham
  • Patent number: 4031142
    Abstract: A process for the production of nuclear chlorinated alkylbenzenes comprises reacting an alkylbenzene with chlorine in the presence of a catalyst system comprising a Lewis acid catalyst and a thianthrene co-catalyst. The nuclear chlorinated alkylbenzene products prepared in this manner are characterized by a substantially reduced ratio of orthochloro to parachloro isomer.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: June 21, 1977
    Assignee: Hooker Chemicals & Plastics Corporation
    Inventor: John C. Graham
  • Patent number: 4013730
    Abstract: A process for the chlorination of toluene comprises reacting toluene with chlorine in the presence of a catalyst system comprising a Lewis acid catalyst and a co-catalyst selected from the group consisting of diphenyl selenide and aluminum selenide. The monochlorotoluene product obtained is characterized by a substantially reduced ratio of orthochlorotoluene to parachlorotoluene.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: March 22, 1977
    Assignee: Hooker Chemicals & Plastics Corporation
    Inventor: John C. Graham
  • Patent number: 3989715
    Abstract: Thianthrene in monochlorotoluene, is reacted with excess chlorine in the presence of a Lewis acid catalyst, to yield a mixture of chlorothianthrenes, the major component of which is 2,3,7,8-tetrachlorothianthrene. Recrystallization of the chlorothianthrene mixture from a suitable solvent, such as tetrahydrofuran yields 2,3,7,8-tetrachlorothianthrene of greater than 90 percent purity.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 2, 1976
    Assignee: Hooker Chemicals & Plastics Corporation
    Inventors: Harry E. Buckholtz, Arun C. Bose, John C. Graham