Abstract: One or more techniques for optimizing cancer classification based on covariate characteristics is disclosed. In a first approach, an analytics system may determine separate cutoff thresholds for positively detecting disease signal for different labels for a covariate characteristic. The system may subdivide training samples based on their labels for the covariate characteristic, to separately determine the cutoff thresholds. In other approaches, the system may train disparate classifiers for each population. The system separates the training samples based on their labels for the covariate characteristic, and separately trains classifiers to generate a signal vector representing an amount of disease signal detected in a sample. The classifiers may be trained on different feature sets as determined based on mutual information gain, genomic region coverage, and healthy activation fraction.

Abstract: In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.

Abstract: An automated carrier system is disclosed for moving objects to be processed. The automated carrier system includes a discontinuous plurality of track sections on which an automated carrier may be directed to move, and the automated carrier includes a base structure on which an object may be supported, and at least two wheels assemblies being pivotally supported on the base structure for pivoting movement from a first position to a second position to effect a change in direction of movement of the carrier.

Abstract: A system is disclosed for providing high flow vacuum control to an end-effector of a programmable motion device. The system includes a vacuum source for providing a high flow vacuum, a conduit path leading from the end-effector to the high flow vacuum source, a sensor system for sensing any of a pressure or a flow at any of the end-effector, the conduit path, and the vacuum source, and providing sensor information, and a pneumatic control module including a vacuum pressure adjustment system for adjusting the high flow vacuum within the conduit path responsive to the sensor information.

Abstract: An antenna for an electronic device comprising of a metal-sheet antenna and an antenna feed connecting the metal-sheet antenna to a radio frequency (RF) printed circuit board (PCB). A screw configured to operate as a ground feed for the metal-sheet antenna and to provide mechanical support in the electronic device wherein the screw is further configured to provide radiation for additional bands for the antenna. The metal-sheet antenna supports a first band, and the screw supports a second band, based on dimensions of a screw boss, and a third band, based on a gap between the screw boss and the metal-sheet antenna.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: Systems and methods include the following. Information about a first electronic communication device is transmitted to at least one server and/or decentralized infrastructure. The information includes vicinity information. A status signal associated with a first user of the first electronic communication device is optionally transmitted. Contact proximity network information about a contact proximity network is received. The contact proximity network is based on the information from a plurality of electronic communication devices and information about the association between users and electronic communication devices. The contact proximity network information includes status signal information and interconnected nodes corresponding to different users and pairwise connections between users based upon their relative physical space and time proximity.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a movable carriage for receiving the selected object from the end effector of the programmable motion device, and for carrying the selected object to one of a plurality of destination bins.

Abstract: Systems and methods include the following. Information about a first electronic communication device is transmitted to at least one server and/or decentralized infrastructure. The information includes vicinity information. A status signal associated with a first user of the first electronic communication device is optionally transmitted. Contact proximity network information about a contact proximity network is received. The contact proximity network is based on the information from a plurality of electronic communication devices and information about the association between users and electronic communication devices. The contact proximity network information includes status signal information and interconnected nodes corresponding to different users and pairwise connections between users based upon their relative physical space and time proximity.

Abstract: In some embodiments, a configurable lighting device, connectors, controllers, and methods for layout detection are provided. The configurable lighting devices, suitably connected, form an assembly of configurable lighting devices that can be removably connected with one another and re-arranged. Connectors are provided that form mechanical and electrical connections between configurable lighting devices such that a flow of electricity and control signals may be propagated without the need for direct connection between every configurable lighting device and a controller. The controller or devices connected to the controller are configured to perform layout detection such that pleasing visualizations may be rendered across the assembly that are rendered using at least the detected layout. When the configuration of the configurable lighting devices changes, the layout detection is automatically updated.

Abstract: The present invention relates to novel compounds and compositions thereof that are useful as antimicrobial agents. The present invention also relates to methods of generating said antimicrobial compounds and compositions thereof as well as methods for treating or preventing a bacterial infection using said compounds or compositions thereof. The present invention further discloses methods for preventing or reducing the growth or proliferation of microorganisms.

Abstract: The present application provides a character input method and apparatus, an electronic device and a medium. The method includes: acquiring and displaying at least one input stroke; retrieving and displaying candidate components containing the at least one input stroke; in response to a component selection instruction to select a target component from the candidate components, displaying the target component and at least one position selection button for selecting a position of the target component; in response to a position selection instruction to select the position of the target component, acquiring a target position corresponding to the position selection instruction; retrieving and displaying candidate characters with the target component at the target position; and in response to a character selection instruction to select a target character from the candidate characters, acquiring the target character.

Abstract: A dental implant includes a body and a threaded surface. The body has an upper portion, a middle portion, and a lower portion. The upper portion of the body includes a generally cylindrical region. The lower portion of the body includes a generally inwardly tapered region. The middle portion of the body includes an outwardly extending bulge. A maximum outer diameter of the bulge is greater than (i) a maximum outer diameter of the upper portion and (ii) a maximum outer diameter of the lower portion. The threaded surface is on the body within at least the upper portion of the body, the bulge, and the lower portion of the body.

Abstract: A dental implant includes a body and a threaded surface. The body has an upper portion, a middle portion, and a lower portion. The upper portion of the body includes a generally cylindrical region. The lower portion of the body includes a generally inwardly tapered region. The middle portion of the body includes an outwardly extending bulge. A maximum outer diameter of the bulge is greater than (i) a maximum outer diameter of the upper portion and (ii) a maximum outer diameter of the lower portion. The threaded surface is on the body within at least the upper portion of the body, the bulge, and the lower portion of the body.

Abstract: A dental implant includes a body and a threaded surface. The body has an upper portion, a middle portion, and a lower portion. The upper portion of the body includes a generally cylindrical region. The lower portion of the body includes a generally inwardly tapered region. The middle portion of the body includes an outwardly extending bulge. A maximum outer diameter of the bulge is greater than (i) a maximum outer diameter of the upper portion and (ii) a maximum outer diameter of the lower portion. The threaded surface is on the body within at least the upper portion of the body, the bulge, and the lower portion of the body.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: A dental implant includes a body and a threaded surface. The body has an upper portion, a middle portion, and a lower portion. The upper portion of the body includes a generally cylindrical region. The lower portion of the body includes a generally inwardly tapered region. The middle portion of the body includes an outwardly extending bulge. A maximum outer diameter of the bulge is greater than (i) a maximum outer diameter of the upper portion and (ii) a maximum outer diameter of the lower portion. The threaded surface is on the body within at least the upper portion of the body, the bulge, and the lower portion of the body.

Abstract: A selectively permeable protective structure and a method for limiting damage to the article due to corrosion or mold growth, comprising wrapping or covering the article in the selectively permeable protective structure. The selectively permeable structure comprises a membrane having a moisture vapor permeation value of at least 200 g-mil/m2/24 h and barrier to liquid water, and optionally a supporting substrate.