Abstract: The present disclosure relates to compounds, compositions, and methods for the treatment of primary hyperoxaluria type 1 and recurrent kidney stone formers. The present disclosure is directed to novel substituted heterocyclic carboxylate compounds and methods for their preparation and use as therapeutic or prophylactic agents. In particular, the present disclosure provides novel inhibitors of human glycolate oxidase enzyme, pharmaceutical compositions containing such compounds, and methods for using these compounds to treat primary hyperoxaluria type 1 and recurrent kidney stone formers.

Abstract: An integrated circuit may include multiple instances of a component (e.g. a processor) and a control circuit. The instances may be configured to operate in various modes. Some of the modes are incapable of presenting a worst-case load on the power supply. The control circuit may be configured to monitor the instances and detect the modes in which the instances are operating. Based on the monitoring, the control circuit may request to recover a portion of the voltage margin established for worst-case conditions in the instances.

Abstract: A gas treatment system configured to purify an influent gas stream including a hydrocarbon gas and a hydrogen sulfide gas comprises a reduction unit and an oxidation unit. The reduction unit includes at least one eductor configured to contact the influent gas stream with a primary stream including aqueous reducing reagent and release a purified hydrocarbon gas stream and a contacted primary stream including elemental sulfur. The oxidation unit includes at least one eductor configured to contact an oxidizing agent stream and a secondary stream including the primary stream and contacted primary stream and output a regenerated redox reagent stream.

Abstract: Secondary batteries and methods of manufacture thereof are provided. A secondary battery can comprise an offset between electrode and counter-electrode layers in a unit cell. Secondary batteries can be prepared by removing a population of negative electrode subunits from a negative electrode sheet, the negative electrode sheet comprising a negative electrode sheet edge margin and at least one negative electrode sheet weakened region that is internal to the negative electrode sheet edge margin, removing a population of separator layer subunits from a separator sheet, and removing a population of positive electrode subunits from a positive electrode sheet, the positive electrode sheet comprising a positive electrode edge margin and at least one positive electrode sheet weakened region that is internal to the positive electrode sheet edge margin, and stacking members of the negative electrode subunit population, the separator layer subunit population and the positive electrode subunit population.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Embodiments of secondary batteries having electrode assemblies are provided. A secondary battery can comprise an electrode assembly having a stacked series of layers, the stacked series of layers having an offset between electrode and counter-electrode layers in a unit cell member of the stacked series. A set of constraints can be provided with a primary constraint system with first and second primary growth constraints separated from each other in a longitudinal direction, and connected by at least one primary connecting member, and a secondary constraint system comprises first and second secondary growth constraints separated in a second direction and connected by members of the stacked series of layers. The primary constraint system may at least partially restrain growth of the electrode assembly in the longitudinal direction, and the secondary constraint system may at least partially restrain growth in the second direction that is orthogonal to the longitudinal direction.

Abstract: A method of routing call signalling to a destination address from a first cellular mobile communications network comprising a plurality of cells to one of a plurality of smaller cells collectively identified in said first mobile communications network by a single virtual cell identifier.

Abstract: An anti-piracy system for a vessel produces a non-lethal all of water along the side of the vessel to wash away a pirate. A cylindrical cap has a top, a bottom edge, a hollow interior, and an outside surface. A slit is defined within the outside surface forming a partial opening within the cap from the interior to the outside surface. A threaded hose fitting is formed within the interior, wherein the cap can be secured to a fire suppression node on the vessel with the downward face positioned over a side of the vessel for forcibly dispersing water through the slit downward over the side of the vessel. The cap is positioned near the deck of the vessel, just over the side of the vessel such that upon activation of the tire suppression system the water is directed downward over the side of the vessel.

Abstract: A telecommunications network termination device has the capability to connect to a network access point using a primary fixed line address by a first route and also, using a second network address, by a backup routing to a shared wireless access point. Connection status messages are transmitted over the primary routing. If these are not detected by the network, it causes traffic to the user device to be diverted over the backup routing to the second network address. It also transmits instructions to the user device to route outgoing traffic by the same secondary route. The secondary route is identified from network topology data stored by the network control server.

Abstract: A mobile communications handset (12) is capable of connection through two different networks (2, 27). When it is out of contact with its preferred local wireless access system (27), the handset will seek a hand-over to the cellular network (2), and will become registered as a “roaming” handset currently connected to the cellular network (2). The cellular network (2) reports this location information to the call server (28), as it would to the HLR of any normal visiting handset, so that incoming calls to the PSTN (6) destined for the user (12) can be routed by way of the cellular network. Outgoing calls are handled as conventional cellular telephony calls. When contact with a local wireless access system (27) is re-established, the contact information is passed to the call server 28, which reports to the cellular network (2) that a handover has occurred.

Abstract: A method of routing call signalling to a destination address from a first cellular mobile communications network comprising a plurality of cells to one of a plurality of smaller cells collectively identified in said first mobile communications network by a single virtual cell identifier.

Abstract: An anti-piracy system for a vessel produces a non-lethal all of water along the side of the vessel to wash away a pirate. A cylindrical cap has a top, a bottom edge, a hollow interior, and an outside surface. A slit is defined within the outside surface forming a partial opening within the cap from the interior to the outside surface. A threaded hose fitting is formed within the interior, wherein the cap can be secured to a fire suppression node on the vessel with the downward face positioned over a side of the vessel for forcibly dispersing water through the slit downward over the side of the vessel. The cap is positioned near the deck of the vessel, just over the side of the vessel such that upon activation of the tire suppression system the water is directed downward over the side of the vessel.

Abstract: An repeater device (11) connects to a master femtocell (cellular access point) (10) device, which in turn connects directly to the Internet (3) by means of a broadband access circuit (2), and through the Internet to the fixed infrastructure of a cellular network. The inbuilt radio configuration services of the repeater femtocell (11) and master femtocell (10) allow it to configure its co-existence with the main femtocell unit, to ensure the optimum coverage is provided for the user, without interference between the two units.

Abstract: A wireless terminal (1) capable of handling voice and data traffic is configured to use an internet connection (3) when available and a connection to a cellular network (7) otherwise. To allow handover between the systems, voice calls using the VoIP protocol are tunnelled to a bridging point (74) between the internet (3) and cellular network (7). However, to avoid the need for data to be routed by way of the cellular network and then back into the internet, the tunnelled connection between the hub and the mobile access bridge (74) is replaced with two separate tunnels (14, 47) respectively connecting the user (1) and MAB (74) with an intermediate breakout point, such as is a VoIP network controller (4). From this breakout point a third connection (46) is made to the internet, for carrying non-voice data traffic by way of a network access control proxy (5).

Abstract: Cordless access over an extended area is provided by a network of co-operating wireless access points (10, 20, 30) etc all operating on a common channel, such that continuous communication with a mobile handset (9) is possible within the combined coverage of the set of access points. The access points are all recognised by the handset (9) as being part of the same connection. The access points are in communication with each other, either by wireless connections (11, 51) or by wired connections (21, 41), so that they can communicate between each other, a home base site controller 60, and a connection (31) to the public network. Under the control of the HBSC (60), all the access points (10, 20), broadcast a common service set identifier SSID and operate on the channel selected by the HBSC (60), and consequently a communications session can continue seamlessly, regardless of which access point is currently in use.

Abstract: If an attempt by a first user to contact another party fails, a callback server sets a flag. The callback server monitors terminals that have such flags set and is arranged to transmit an alert to the calling party when the called party next becomes available. However, if at the time when the called party becomes available, the calling party is himself no longer available, being now switched off or busy, an additional flag in the store, indicative of activity by the calling party, prevents a callback alert from being generated until the monitoring process can obtain availability indications in respect of both parties simultaneously. Availability may be determined by factors such as available bandwidth or terminal capabilities. A callback may be initiated when a predetermined number of called parties become available to participate in a conference call.

Abstract: For each of a number of users (11, 12, 13), a network-based server (14) maintains a respective data set (141, 142, 143) of each data file currently stored on the user device, such as scheduling details, electronic mail, documents, etc. Each data set comprises a master copy (161) indicative of the latest data intended for that user (11). When a user (either the user associated with the user device, or some other user (151, 152, 153) authorised to do so) makes a change to the user data, for example rescheduling a meeting, the master copy (161) is updated. The server (14) also identifies how this data differs from that held on a second copy (171), which duplicates what is currently stored on the terminal, and generates a third dataset (181) identifying the changes that would need to be made to change the duplicate copy (171) to correspond to the master copy (161). This change data is forwarded to the user terminal when it next makes contact with the network.

Abstract: The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

Abstract: A telecommunications network termination device has the capability to connect to a network access point using a primary fixed line address by a first route and also, using a second network address, by a backup routing to a shared wireless access point. Connection status messages are transmitted over the primary routing. If these are not detected by the network, it causes traffic to the user device to be diverted over the backup routing to the second network address. It also transmits instructions to the user device to route outgoing traffic by the same secondary route. The secondary route is identified from network tolopogy data stored by the network control server.