Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: An information storage device may be semi-permanently attached to a wearer. The device can include an outer casing configured to be compatible with long term contact with a human body. A data storage component may store information of the wearer and a transceiver may wirelessly communicate information from the data storage component. The stored information can be, for example, the complete medical history of the wearer, “emergency” medical information, prescriptions, medical warnings (e.g., past history of coronary problems), financial information, social security numbers, or other useful information.

Abstract: An email review tool gives users a simple, quick, and safe method of initiating review of an email document. The email review tool may provide a window to a user which allows the user to select another person to review the email or skip the review process and send the email directly to the recipients. Transmission of the email is thus deferred until the email has been reviewed.

Abstract: An email review tool gives users a simple, quick, and safe method of initiating review of an email document. The email review tool may provide a window to a user which allows the user to select another person to review the email or skip the review process and send the email directly to the recipients. Transmission of the email is thus deferred until the email has been reviewed.

Abstract: An email review tool gives users a simple, quick, and safe method of initiating review of an email document. The email review tool may provide a window to a user which allows the user to select another person to review the email or skip the review process and send the email directly to the recipients. Transmission of the email is thus deferred until the email has been reviewed.

Abstract: An automatic weight selector for exercise equipment is characterized by a screw mechanism for adding or subtracting weight applied to a carriage on the equipment. A plurality of weights are slidably connected with the equipment. The weights contain central threaded through-openings which are in alignment when the weights are arranged in a stack. The screw mechanism has a vertical axis aligned with the threaded openings in the weights. Thus, the screw can be rotated to connect or disconnect one or more weights to the carriage. A remote-controlled motor is provided to rotate the screw, thereby enabling a user to easily and automatically adjust the weight applied to the exercise equipment.

Abstract: A one-piece leg strap for a U-shaped fluorescent lamp having two longitudinally extending leg members joined together by a U-bend portion. The leg brace includes an elongated central body portion and a pair of generally circular end portions. Each of the circular end portions defines an opening therewithin having an inside diameter relative to the outside diameter of a respective lamp base member. A non-slip friction fit retains the leg strap on the lamp base members. Means are provided in the leg strap to compensate for variations in the outside diameter of the lamp base members. In a preferred embodiment, a pair of notches are located at opposite ends of the central body portion and define first and second laterally flexible projecting members which allow the end portions of the leg brace to be easily slipped over the lamp base members.