Abstract: A method of making a model test system in guinea pigs for leiomyomas and early stage atherosclerosis by ovariectomizing young female guinea pigs, and co-implanting a continuous slow release device for releasing an estrogenic compound or analog thereof and a retinoid compound or analogs thereof.

Abstract: Serial assay of guaiacol peroxidase (G-P.sub.x) in the cervical mucus of human females during the menstrual cycle demonstrated that G-P.sub.x levels decrease 20- to 100-fold in the middle of the cycle relative to levels at other times in the cycle. Cervical mucus can be sampled either at the external cervical os or in the vaginal canal. The test for assaying G-P.sub.x includes extracting the sample with a Ca.sup.++ -containing buffer solution at a slightly alkaline pH, and thereafter adding guaiacol and a peroxide. Decreasing levels of G-P.sub.x are indicated by a color change from deep red to pink to yellow. The decrease was found to coincide with the peak of plasma estrogens that normally precedes ovulation. Accordingly, the test provides a reliable prediction of impending ovulation and is therefore useful in the practice of natural fertility control.

Abstract: A polymer suitable for use in affinity chromatography comprising a polymer f an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction with a portion of the pendant halo-methyl groups and the remainder of said pendant halo-methyl groups are reacted with an amine containing a pendant hydrophilic group. The invention also comprises a method of coating a substrate with the above polymer and a method of fractionating mixtures by affinity chromatography employing the above polymer as an adsorbent.

Abstract: A polymer suitable for use in affinity chromatography comprising a polymer of an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction with a portion of the pendant halo-methyl groups and the remainder of said pendant halo-methyl groups are reacted with an amine containing a pendant hydrophilic group.

Abstract: A polymer suitable for use in affinity chromatography comprising a polymer f an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction with a portion of the pendant halo-methyl groups and the remainder of said pendant halo-methyl groups are reacted with an amine containing a pendant hydrophilic group. The invention also comprises a method of coating a substrate with the above polymer and a method of fractionating mixtures by affinity chromatography employing the above polymer as an adsorbent.

Abstract: A polymer suitable for use in affinity chromatography comprising a polymer f an aminimide and a vinyl compound having at least one pendant halo-methyl group and the said polymer wherein an amine ligand which affords sites for binding in affinity chromatography is coupled to the polymer by reaction with a portion of the pendant halo-methyl groups and the remainder of said pendant halo-methyl groups are reacted with an amine containing a pendant hydrophilic group.The invention also comprises a method of coating a substrate with the above polymer and a method of fractionating mixtures by affinity chromatography employing the above polymer as an adsorbent.