Patents by Inventor John C. Manteiga

John C. Manteiga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATION OF TRANSCRIPTION THROUGH CTCF LOOP ANCHORS
    Publication number: 20240141335
    Abstract: Disclosed are methods of altering expression of a gene with a promoter region CTCF binding site. Also disclosed are compositions and methods useful for treating a disease or condition involving over-expression or under-expression of a gene with a promoter region CTCF binding site. Further disclosed are cells and non-human animals with modified a promoter region CTCF binding site, as well as methods for screening for compounds that can modify the expression of a gene with a promoter region CTCF binding site.
    Type: Application
    Filed: June 5, 2023
    Publication date: May 2, 2024
    Inventors: Jurian Schuijers, Abraham S. Weintraub, John C. Manteiga, Richard A. Young
  • METHODS OF IDENTIFYING A CONDENSATE PHENOTYPE AND USES THEREOF
    Publication number: 20240145034
    Abstract: The present application provides, in some aspects, methods of identifying a condensate of interest associated with a el disease. Also provided are methods of identifying a marker for identifying a condensate of interest associated with a disease. In other aspects, provided herein are methods of identifying a therapeutic agent useful for treating a disease via the identified condensate of interest.
    Type: Application
    Filed: March 1, 2022
    Publication date: May 2, 2024
    Inventors: William W. CHEN, John C. MANTEIGA, Violeta YU, Ann D. KWONG, Peter Jeffrey DANDLIKER, Bruce Aaron BEUTEL, Chi ZHANG, Lingyao ZENG, Andreas STEFFEN, Daniel Franz FREITAG
  • COMPOSITIONS, SYSTEMS, AND METHODS FOR IDENTIFYING A COMPOUND THAT MODULATES ONE OR MORE CHARACTERISTICS ASSOCIATED WITH A RBM20 CONDENSATE AND/OR A RBM20 POLYPEPTIDE
    Publication number: 20220365070
    Abstract: The present disclosure, in some aspects, is directed to methods for screening and identifying compounds that modulate one or more characteristics associated with a condensate comprising a RBM20 polypeptide and/or the RBM20 polypeptide. In other aspects, the disclosure is directed to systems and composition components thereof, such as cellular models useful for the methods described herein.
    Type: Application
    Filed: September 17, 2020
    Publication date: November 17, 2022
    Inventors: Avinash PATEL, Mark Andrew MURCKO, Stephen Paul HALE, Bruce Aaron BEUTEL, Bozena KESIC, Juwina WIJAYA, John C. MANTEIGA, Peter Jeffrey DANDLIKER, Ann D. KWONG
  • METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES
    Publication number: 20220120736
    Abstract: Described herein are compositions and methods for modulating gene regulation by modulating condensate formation, composition, maintenance, dissolution and regulation.
    Type: Application
    Filed: March 22, 2019
    Publication date: April 21, 2022
    Inventors: Richard A. Young, Phillip A. Sharp, Arup K. Chakraborty, Alessandra Dall'Agnese, Krishna Shrinivas, Brian J. Abraham, Ann Boija, Eliot Coffey, Daniel S. Day, Yang E. Guo, Nancy M. Hannett, Tong Ihn Lee, Charles H. Li, Isaac Klein, John C. Manteiga, Benjamin R. Sabari, Jurian Schuijers, Abraham S. Weintraub, Alicia V. Zamudio, Lena K. Afeyan, Ozgur Oksuz, Jonathan E. Henninger
  • REGULATION OF TRANSCRIPTION THROUGH CTCF LOOP ANCHORS
    Publication number: 20200149039
    Abstract: Disclosed are methods of altering expression of a gene with a promoter region CTCF binding site. Also disclosed are compositions and methods useful for treating a disease or condition involving over-expression or under-expression of a gene with a promoter region CTCF binding site. Further disclosed are cells and non-human animals with modified a promoter region CTCF binding site, as well as methods for screening for compounds that can modify the expression of a gene with a promoter region CTCF binding site.
    Type: Application
    Filed: December 12, 2017
    Publication date: May 14, 2020
    Inventors: Jurian Schuijers, Abraham S. Weintraub, John C. Manteiga, Richard A. Young