Patents by Inventor John C. McKew

John C. McKew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making an aldehyde
    Patent number: 6984735
    Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: January 10, 2006
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark, Wei Li
  • Inhibitors of phospholipase enzymes
    Patent number: 6916841
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 12, 2005
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Inhibitors of cytosolic phospholipase A2
    Patent number: 6797708
    Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: September 28, 2004
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Process for making an aldehyde
    Publication number: 20040082785
    Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
    Type: Application
    Filed: November 26, 2003
    Publication date: April 29, 2004
    Applicant: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark, Wei Li
  • N-benzhydryl indole compounds
    Patent number: 6635771
    Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of phospholipase enzymes
    Patent number: 6630496
    Abstract: This invention provides substituted indole and indoline compounds useful in inhibiting phospholipase activity, particularly including cytosolic phospholipase A2 (cPLA2) activity, as well as pharmaceutical compositions containing the compounds and methods of using them to treat various maladies, including pain and inflammatory conditions.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: October 7, 2003
    Assignee: Genetics Institute LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Jean E. Bemis, YiBin Xiang, Lihren Chen
  • Methods for treating arthritic disorders
    Publication number: 20030166649
    Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • N-BENZHYDRYL INDOLE COMPOUNDS
    Publication number: 20030158405
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of phospholipase enzymes
    Publication number: 20030153751
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Application
    Filed: May 8, 2002
    Publication date: August 14, 2003
    Applicant: American Home Products Corporation
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Methods for treating asthmatic conditions
    Publication number: 20030149029
    Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20030144282
    Abstract: This invention provides substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf