Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A motion and orientation responsive device having a pendulum pivotally mounted between its ends, and means for detecting relative displacement of the upper pendulum end and a zero position reference on the pendulum support from certain normal relative positions thereof in response to either or both translational and rotational displacements of the device. Presently preferred embodiments of the invention are a seismic or earthquake alarm, an intrusion alarm, and a tilt alarm. In these preferred embodiments, the pendulum shaft is a slender resilient wire, and its pivot is situated close to its lower center of mass in order to amplify the lateral motion of the upper pendulum end for a given angle of pendulum rotation and thereby enhance the sensitivity of the device to low magnitude displacements.

Abstract: A hinge having at least three leaves pivotally joined along edges of the leaves and adapted for attachment to two members to be pivotally connected with at least one member secured to a pair of the leaves which are mutally inclined in such a way that each leaf of the pair resists bending of the other leaf of the pair. A present best mode embodiment of the hinge has four leaves and is designed primarily for use on so-called ultralight airplanes as aileron, rudder, and elevator hinges which are immune to fatigue stress failure. Another hinge embodiment is designed for use as a door hinge and has only three leaves.

Abstract: A parking stand for supporting the tongue of a parked trailer. The parking stand has a coupling ball at its upper end for engagement in the socket of a coupling part on the front end of the trailer tongue and a castor wheel or fixed base at its lower end for supporting the stand on the ground. A clamp on the upper end of the stand acts against the trailer coupling part to secure the stand against swivel movement relative to the trailer tongue.

Abstract: Readily portable apparatus for exterminating animal pests, particularly rodents such as gophers which burrow through the ground. The apparatus includes a small, lightweight internal combustion engine, and means for directing the engine exhaust into exterminating relationship to the pests, such as into a burrow or tunnel of a ground burrowing rodent. The preferred engine is a two-cycle engine which burns a fuel/oil mixture to produce exhaust containing smoke which asphyxiates, carbon monoxide which effectively poisons, and intense pressure pulsations which tend to drive a rodent from an underground tunnel, such that the rodent faces the delema of remaining underground and dying from the effects of the exhaust gas or coming to the surface and exposing himself to death in other ways above ground. In the presently preferred apparatus, the engine is mounted on an inverted bowl-shaped exhaust shroud which seats on the ground to direct the engine exhaust into an underground rodent burrow.

Abstract: A relatively simple, lightweight, low cost brake assembly for relatively light weight vehicles, particularly so-called ultralight airplanes which may be quickly and easily installed on and removed from a vehicle. The brake assembly has a housing to be fixed on a vehicle wheel support, such as an axle, and rotatably mounting a brake rotor having means for compling to a wheel. Operable between the housing and rotor are selectively operable brake means for applying a braking force to the rotor.

Abstract: An improved engine mount for model airplanes which significantly increases usable engine power by reducing engine oscillation and thereby also engine power loss due to such oscillation and which greatly facilitates installation and removal of the engine. The mount comprises a relatively stiff mounting block substantially coaxial with the engine crankshaft rotation axis and extending between and rigidly secured to the rear end of the engine crankcase and an engine mounting wall or the like on the airplane at the rear of the engine. The preferred engine mount has a generally cylindrical spool-like shape with front and rear end flanges containing holes to receive screws for securing the mount to the engine and engine mounting wall.

Abstract: This invention is a lubrication pumping means contained within one or more reciprocating rods to assure lubrication of the crankpin rod bearing and the wrist pin bearing during operation of a two-cycle internal combustion engine. The invention teaches a means to collect and retain a column of lubricating fluid within a longitudinal bore formed in the rod.

Abstract: This invention is a lubrication pumping means contained within one or more reciprocating rods to assure lubrication of the crankpin rod bearing and the wrist pin bearing during operation of a two-cycle internal combustion engine.

Abstract: This invention is a unique lubrication means contained within a hollow shank of a reciprocating rod including a valve means to maintain a supply of lubricant within the shank of the rod to assure proper lubrication of both the crankpin and wrist pin rod bearings during operation of a two-cycle internal combustion engine.

Abstract: This invention is a lubrication pumping means contained within one or more reciprocating rods to assure lubrication of the crankpin rod bearing and the wrist pin bearing during operation of a two-cycle internal combustion engine.

Abstract: A positive displacement liquid pump having a free-moving weight mass spaced from and oscillatably positioned concentrically within a cylindrical housing is disclosed. A pair of cooperating one-way valves, one valve communicating with a central passage defined by the weight mass while the other valve communicates with an inlet to the housing, coact to draw in fluid or liquid from a supply source. As the oscillatable weight mass moves away from the inlet, the one-way inlet valve opens, filling a chamber behind the weight mass. The one-way valve in the weight mass simultaneously closes enabling the weight mass to drive fluid out of the reservoir chamber at an exit end of the housing, the valves acting oppositely when the weight mass oscillates back toward the housing inlet. The free-moving weight mass suspended within the pump housing is set in motion by the oscillatory motion of a vibration source without direct mechanical actuation of the device from a power source.

Abstract: This invention relates to a positive displacement pump. The pump utilizes a source of rotary motion in the back and forth, clockwise, counterclockwise direction. The rotary oscillatory motion drives an annular piston weight mass in a toroidal rotary track, back and forth within the track in combination with at least a pair of one-way valves to pump fluid through the pump. Specially designed electric motors that rock back and forth, without a 360.degree. rotation, for example, may be coupled to a positive displacement pump of this invention. In the medical profession, this pump may be used to pump liquids at a very slow, precise rate to transmit, for example, a variety of medications into a patient.

Abstract: A positive displacement liquid pump having a free stroking piston slidably positioned within a cylindrical housing is disclosed. A pair of cooperating one-way valves, one valve communicating with a central passage defined by the piston while the other valve communicates with an inlet to the housing, coact to draw in fluid from a source of liquid. As the piston moves away from the inlet the one-way inlet valve opens filling a chamber behind the piston. The one-way valve in the piston simultaneously closes enabling the piston to drive fluid out of the reservoir chamber at an exit end of the housing, the valves acting oppositely when the piston oscillates back toward the housing inlet. The free stroking piston within the pump is set in motion by the oscillatory motion of vibration alone without direct mechanical piston actuation from a power source. The pump may cooperate with a fluid regulator to control flow of fluid from the pump housing.

Abstract: This invention is a heavy-duty flexible shaft that accommodates for misalignments between an input and output shaft. The flexible shaft is comprised of a multiplicity of hollow, individually fabricated, interfitting members housed in a tubular, bendable shaft. Each segment is intimately engaged, one within the other, yet the segments are so designed to allow for limited longitudinal movement while restricting circumferential movement between segments during torsional transmissions from the input to the output shafts.

Abstract: A two cycle internal combustion engine with improved cylinder scavenging. The described engine embodiment is a baffled piston two cycle internal combustion engine whose power is substantially increased by directing fuel mixture in the normally spent gas filled region behind the piston baffle during each intake-exhaust portion of the engine cycles to scavenge spent gas from this region and increase the total volume of fuel mixture in the cylinder at the time of ignition. According to the preferred practice of the invention a portion of the fuel mixture displaced from the engine crankcase to the cylinder intake port or ports is diverted to auxiliary ports in the cylinder wall which direct the mixture against the rear side of the piston baffle to effect through scavenging of the region directly behind the baffle.

Abstract: A trimming wedge is disclosed to trim a propeller driven boat for better performance. The wedge is fixed at its base to the center shaft housing of a propeller driven power boat. The trimming wedge extends approximately the length of one blade of the propeller and is positioned in front of and in line with the propeller blade. The trimming wedge or vane splits the water in front of the propeller so that the blade of the propeller passes through a void in the water. For example, when the wedge is positioned vertically downwardly from the shaft housing, the void occurs when the clockwise arc of the blade is in about the downward four o'clock to eight o'clock position when viewed from the rear. A trimming wedge with the proper wedge angle neutralizes the tendency of the propeller to "walk" the boat sideways or to the right with a clockwise turning propeller, thus transferring the side load thrust to forward thrust when the boat is propelled through the water, resulting in an increase in forward speed.

Abstract: A fuel pump for an internal combustion engine of the type wherein cyclic pressure fluctuations are produced in the engine crankcase chamber during engine operation by the reciprocating motion of an engine piston. The pump embodies fuel pumping means including a pulsatory pumping member or pulsator, such as a diaphragm, and is mounted directly on the engine with the pumping pulsator exposed directly to the engine crankcase chamber in such a way that the chamber pressure fluctuations drive the pulsator in its pulsating pumping motion to pump fuel from the fuel inlet to the fuel outlet of the pump. Also embodied in the pump are a novel fuel pressure regulating valve for maintaining a substantially constant fuel outlet pressure regardless of engine speed and an automatic fuel shut-off valve for blocking fuel leakage through the pump under the action of head pressure or other forces when engine operation ceases.