Patents by Inventor John C. Price

John C. Price has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9658213
    Abstract: An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins. Tissue samples are removed from the subject at different points in time and proteins are extracted and separated so that different proteins of different tissues can be individually analyzed and their amount and pattern of isotopic labeling can be determined. In a preferred embodiment, the methodology can be combined with proteolytic digestion to peptides and analysis by mass spectrometry in order to measure rates of protein turnover in vivo relating to thousands of different proteins.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: May 23, 2017
    Assignee: The Regents of the University of California
    Inventors: Stanley B. Prusiner, John C. Price, Sina Ghaemmaghami, Al Burlingame, Shenheng Guan
  • Patent number: 8847596
    Abstract: A shim coil assembly for positioning shim coils in a narrow gap between magnetic poles of miniature NMR devices around the magnetic center includes electric traces on multiple levels of printed circuit board layers in various, overlapping configurations. Mirror image shim coils can be connected in series in a symmetric sense or connected in series in a antisymmetric sense.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 30, 2014
    Assignee: picoSpin, LLC
    Inventors: John C. Price, Michael Steinbach, Chris Jonkman
  • Publication number: 20140287957
    Abstract: An entire complement or plurality of isotopically labeled amino acids are introduced into the diet of a test subject. Sufficient amounts of the isotopically labeled amino acids are provided to the subject in order to ensure that the subject incorporates a large percentage of isotopically labeled amino acids into newly synthesized proteins. Tissue samples are removed from the subject at different points in time and proteins are extracted and separated so that different proteins of different tissues can be individually analyzed and their amount and pattern of isotopic labeling can be determined. In a preferred embodiment, the methodology can be combined with proteolytic digestion to peptides and analysis by mass spectrometry in order to measure rates of protein turnover in vivo relating to thousands of different proteins.
    Type: Application
    Filed: June 17, 2011
    Publication date: September 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Stanley B. Prusiner, John C. Price, Sina Ghaemmaghami, Al Burlingame, Shenheng Guan
  • Patent number: 8754646
    Abstract: A method is provided for acquiring multiple NMR response signal data in rapid succession for averaging NMR spectral data from a sample. The fluid sample is placed in a capillary that extends through the magnetic field of the NMR spectrometer, including through the center of the magnetic field to place a segment of the sample in the magnetic center. After the sample fluid, initially magnetized by the magnetic field, is activated to emit an NMR pulse signal, the fluid in the capillary is advanced rapidly to put another pre-magnetized segment of the sample fluid in the fluid center, acquiring an NRM pulse signal, and continuing the cycle until a desired number of NMR response data signals from the sample have been acquired. Those response data from multiple acquisitions are then averaged.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: June 17, 2014
    Assignee: Picospin, LLC
    Inventors: John C. Price, Charles Miller, Erick Winston
  • Patent number: 8729898
    Abstract: A capillary cartridge assembly for positioning a sample fluid at a geometric center between juxtaposed pole pieces of a NMR magnet assembly for NMR analysis comprises a capillary captured in a channel in a printed circuit board assembly that is sized to fit between the pole pieces. The assembly includes a RF coil surrounding a portion of the capillary. Electric traces shaped to function as shim coils can be included in the printed circuit board. An end of the printed circuit board includes electrically conductive contacts that plug into a receptacle to connect the RF coil and traces to external electrical circuitry when the RF coil is in the geometric center. The capillary can be a continuous flow-through capillary or a closed cartridge.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: May 20, 2014
    Assignee: Picospin, LLC
    Inventors: John C. Price, Chris Jonkman
  • Patent number: 8674698
    Abstract: A single-pole, double-throw, transmit/receive switch for switching a NMR coil between a transmit mode and a receive mode comprises two diode bridge switches on opposites sides of a node the is common with the two diode bridges and the NMR coil. One of the two diode bridges is positioned between the coil and a preamplifier for signals received from the coil, and the other diode bridge is positioned between the coil and a RF signal transmitter for connecting and disconnecting transmitted signals to and from the coil. The NMR coil is connected to the switches through a resonant impedance matching network.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: March 18, 2014
    Assignee: picoSpin, LLC
    Inventor: John C. Price
  • Patent number: 8349080
    Abstract: A micro-manipulator machine for harvesting and cryofreezing crystals for cryogenic storage and subsequent analysis includes a micropositioner mechanism for converting motions manually input to a position control knob to fractionally-scaled motions of a follower mechanism which includes a tool head support arm and tool head that releasably holds a filamentary polymer cryoloop for immersion into a liquid crystal growth media and extraction of a liquid drop containing a selected crystal from the media. A first automatic actuator mechanism orbits the tool head support arm, tool head, cryoloop, liquid drop and harvested crystal from a harvesting location to a retrieval location when the micropositioner input control arm has been moved manually away from the crystal harvesting location by the operator after extracting a crystal drop, and a second automatic actuator mechanism pivots the toll head into a flowing stream of a cryogenic gas to freeze the liquid drop and crystal.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: January 8, 2013
    Assignee: West Bond, Inc.
    Inventor: John C. Price
  • Publication number: 20120001636
    Abstract: A shim coil assembly for positioning shim coils in a narrow gap between magnetic poles of miniature NMR devices around the magnetic center includes electric traces on multiple levels of printed circuit board layers in various, overlapping configurations. Mirror image shim coils can be connected in series in a symmetric sense or connected in series in a antisymmetric sense.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 5, 2012
    Inventors: John C. Price, Michael Steinbach, Chris Jonkman
  • Publication number: 20110316535
    Abstract: A capillary cartridge assembly for positioning a sample fluid at a geometric center between juxtaposed pole pieces of a NMR magnet assembly for NMR analysis comprises a capillary captured in a channel in a printed circuit board assembly that is sized to fit between the pole pieces. The assembly includes a RF coil surrounding a portion of the capillary. Electric traces shaped to function as shim coils can be included in the printed circuit board. An end of the printed circuit board includes electrically conductive contacts that plug into a receptacle to connect the RF coil and traces to external electrical circuitry when the RF coil is in the geometric center. The capillary can be a continuous flow-through capillary or a closed cartridge.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Inventors: John C. Price, Chris Jonkman
  • Publication number: 20110316540
    Abstract: A single-pole, double-throw, transmit/receive switch for switching a NMR coil between a transmit mode and a receive mode comprises two diode bridge switches on opposites sides of a node the is common with the two diode bridges and the NMR coil. One of the two diode bridges is positioned between the coil and a preamplifier for signals received from the coil, and the other diode bridge is positioned between the coil and a RF signal transmitter for connecting and disconnecting transmitted signals to and from the coil. The NMR coil is connected to the switches through a resonant impedance matching network.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Inventor: John C. Price
  • Publication number: 20110316536
    Abstract: A method is provided for acquiring multiple NMR response signal data in rapid succession for averaging NMR spectral data from a sample. The fluid sample is placed in a capillary that extends through the magnetic field of the NMR spectrometer, including through the center of the magnetic field to place a segment of the sample in the magnetic center. After the sample fluid, initially magnetized by the magnetic field, is activated to emit an NMR pulse signal, the fluid in the capillary is advanced rapidly to put another pre-magnetized segment of the sample fluid in the fluid center, acquiring an NRM pulse signal, and continuing the cycle until a desired number of NMR response data signals from the sample have been acquired. Those response data from multiple acquisitions are then averaged.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Inventors: John C. Price, Charles Miller, Erick Winston
  • Publication number: 20110001474
    Abstract: Methods and apparatus for obtaining NMR signals from a flowing fluid include permanent magnet assemblies for producing magnetic fields for NMR applications and instrumentations, including, but not limited to, flow metering.
    Type: Application
    Filed: December 10, 2009
    Publication date: January 6, 2011
    Applicant: CEMA TECHNOLOGIES, LLC
    Inventors: Charles E. Miller, John C. Price
  • Patent number: 6628016
    Abstract: Molecular dipolar rotors comprising a base, an axle connected to said base and oriented substantially perpendicular to said base, and a rotor portion having an electric dipole moment are provided. The molecular dipolar rotors may be attached to a surface. Arrays of molecular dipolar rotors attached to surfaces are provided. Molecular dipolar rotors are useful in preparation of small devices.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: September 30, 2003
    Assignee: California Molecular Electronics Corporation
    Inventors: Josef Michl, John C. Price, Thomas F. Magnera
  • Patent number: 6337453
    Abstract: An improved apparatus and method for forming a fusion ball at the end of a wire protruding from an ultrasonic bonding tool preparatory to making a ball bond to a workpiece includes shielding means for attenuating electromagnetic interference (EMI) emissions from an electrical arc discharge used to form the ball, which EMI emissions may damage sensitive electronic circuitry on a workpiece. In a preferred embodiment, a ball-forming arc discharge to a wire end occurs with a spark chamber in an electrically conductive electrostatic shield and preferably includes a ferromagnetic shield cup surrounding the chamber. According to the method of the present invention, a capillary ultrasonic bonding tool having a severed end of a gold bonding wire protruding from a capillary bore through the tool is moved away from a vertical line of action between the tool and a workpiece.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: January 8, 2002
    Assignee: West Bond, Inc.
    Inventors: Charles F. Miller, John C. Price
  • Publication number: 20010033937
    Abstract: Molecular dipolar rotors comprising a base, an axle connected to said base and oriented substantially perpendicular to said base, and a rotor portion having an electric dipole moment are provided. The molecular dipolar rotors may be attached to a surface. Arrays of molecular dipolar rotors attached to surfaces are provided. Molecular dipolar rotors are useful in preparation of small devices.
    Type: Application
    Filed: March 20, 2001
    Publication date: October 25, 2001
    Inventors: Josef Michl, John C. Price, Thomas F. Magnera
  • Patent number: 5589845
    Abstract: The disclosure relates to ferroelectric and superconducting thin films used in combination to produce low-loss passive microwave and millimeter wave devices which are frequency tuneable. Various metal oxide superconducting and ferroelectric thin films can be deposited in numerous multilayer geometries via a variety of deposition techniques to produce devices which can manipulate microwave and millimeter wave signals through the application of voltage bias signals across the ferroelectric films. Numerous superconducting microwave and millimeter wave devices, including delay lines, phase shifters, resonators, oscillators, filters, electrically-small antennas, half-loop antennas, directional couplers, patch antennas, and various radiative gratings, are made frequency-tuneable by utilizing voltage-tuneable capacitor structures fabricated from voltage-biased ferroelectric thin films.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 31, 1996
    Assignee: Superconducting Core Technologies, Inc.
    Inventors: Robert M. Yandrofski, John C. Price, Frank Barnes, Allen M. Hermann, James F. Scott
  • Patent number: 5472935
    Abstract: The disclosure relates to ferroelectric and superconducting thin films used in combination to produce low-loss passive microwave and millimeter wave devices which are frequency tuneable. Various metal oxide superconducting and ferroelectric thin films can be deposited in numerous multilayer geometries via a variety of deposition techniques to produce devices which can manipulate microwave and millimeter wave signals through the application of voltage bias signals across the ferroelectric films. Numerous superconducting microwave and millimeter wave devices, including delay lines, phase shifters, resonators, oscillators, filters, electrically-small antennas, half-loop antennas, directional couplers, patch antennas, and various radiative gratings, are made frequency-tuneable by utilizing voltage-tuneable capacitor structures fabricated from voltage-biased ferroelectric thin films.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: December 5, 1995
    Inventors: Robert M. Yandrofski, John C. Price, Frank Barnes, Allen M. Hermann, James F. Scott
  • Patent number: 4257767
    Abstract: In controlling a slab reheat furnace, the average temperature of each slab in a zone, is predicted as a function of the radiation heat source temperature in the zone, and the thermal properties, dimensions, location, velocity, and past thermal history of the slabs. The predicted slab temperatures are compared with a range of desired slab temperatures and the slab requiring the greatest time to be heated to its desired temperature is identified. The furnace is controlled in such a manner that the identified slab will be heated to the desired temperature. Slabs likely to be overheated are identified and, if a predetermined temperature limit is to be exceeded, the furnace is controlled to prevent further heating of the slabs. Gas temperatures throughout the zone are predicted based upon only one sensed temperature in the zone.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: March 24, 1981
    Assignee: General Electric Company
    Inventor: John C. Price
  • Patent number: D373884
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: September 17, 1996
    Inventor: John C. Price