Abstract: A system and method for providing video conferencing are described herein. Original video streams from one or more cameras are sampled to form downscaled versions of the video stream. The downscaled version is analyzed to find regions of interest and generate metadata describing aspects of the regions of interest, including a region that includes a preferred speaker and the best view of each participant present together in the video conference. Cropping instructions are generated from the metadata, and portions of the original video stream are removed to form a set of presentation views for each participant, including the preferred speaker. The set of presentation views is stitched together to form a composite display for each participant viewing the stream remotely.

Abstract: Method and systems for cleaning and wetting a semiconductor substrate, are provided. Methods and systems include forming an atmosphere in a basin housing the semiconductor substrate with a gas having a higher solubility in a wetting agent than oxygen. Methods and systems include spraying the wetting agent with a spray head onto the substrate while maintaining the atmosphere. Methods and systems include rotationally translating the semiconductor substrate, the spray head, or both the semiconductor substrate and the spray head, Methods and systems include wetting a plurality of features defined in the substrate.

Abstract: In various examples, physical sensor data may be generated by a vehicle in a real-world environment. The physical sensor data may be used to train deep neural networks (DNNs). The DNNs may then be tested in a simulated environment—in some examples using hardware configured for installation in a vehicle to execute an autonomous driving software stack—to control a virtual vehicle in the simulated environment or to otherwise test, verify, or validate the outputs of the DNNs. Prior to use by the DNNs, virtual sensor data generated by virtual sensors within the simulated environment may be encoded to a format consistent with the format of the physical sensor data generated by the vehicle.

Abstract: The disclosed methods, systems, and kits provide the ability to deliver entire clean sheet designs from concept to first hot fire in under six weeks with instant specific impulses above 330 seconds in some of our engines. In examples, thrusters can be delivered that are at less than half of the mass budget allowable for them and they can be delivered in weeks.

Abstract: The present invention relates to protein markers for luminal A (LA)-like and luminal B1 (LB 1)-like breast cancer. Methods for differentiating LA-like and LB 1-like breast cancer in a ER-positive breast cancer subject are provided, such methods including the detection of levels of a variety of biomarkers for LA-like and LB 1-like breast cancer. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: A system for monitoring auditory health of a user can include an auricular device that can comprise a microphone configured to generate OAE audio data responsive to detecting one or more otoacoustic emissions originating from the inner ear of the user. One or more hardware processors associated with the auricular device can access the OAE audio data from the microphone; access physiological data of the user originating from a physiological sensor; determine a feature of the physiological data in a time-domain, the feature comprising a value of the physiological data exceeding a threshold; adjust a portion of the OAE audio data based on the feature of the physiological data, the portion of the OAE audio data corresponding to the feature of the physiological data in the time-domain; and determine one or more physiological characteristics of the user based on the OAE audio data.

Abstract: Protein constructs comprising a BTNL3/8 targeting moiety, a payload and an optional linker are described herein. Pharmaceutical compositions comprising the constructs, and methods of use thereof are presented.

Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.

Abstract: Disclosed herein are systems and methods for setting, accessing, and modifying user privacy settings using a distributed ledger. In an aspect, a system can search previously stored software contracts to locate an up-to-date version of a software contract associated with a user based on a request for access to user data for the particular user. Then, the system determines that the user data is permitted to be shared. The system transmits, to a data virtualization platform, instructions to extract encrypted user data from a data platform. The system can then make available, to a data verification system, a private encryption key and details associated with the software contract to verify that the private encryption key and the user data match. Then the system transmits, to the data virtualization platform, the private encryption key so that the data virtualization platform can decrypt the encrypted user data.

Abstract: A tissue anchor includes a memory metal wire configured to transition between an at least partially straightened delivery configuration and an expanded deployed configuration forming an anchor and a suture-attachment feature configured to have a suture coupled thereto. In the expanded deployed configuration, one or more portions of the memory metal wire extend radially outward from a center of the tissue anchor.

Abstract: Embodiments include humanized anti-LGR5 antibodies for the treatment of cancer. Some embodiments include antibodies which may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Some embodiments include heavy and light chain polypeptide sequences for the binding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.

Abstract: Disclosed herein is an apparatus for containing and dispensing reagent into a microfluidic cartridge for use in sample-to-answer or point-of-care instruments. The apparatus contains a reagent dispensing unit, such as a reagent blister. The blister can contain one or more vessels for containment of reagents and a rupturable seal that blocks the flow of reagent from the reagent blister through an interface and into the microfluidic cartridge.

Abstract: The disclosed end-to-end product customization systems and methods receive custom orders from customers or consumers, evaluate them, and generate production-ready custom orders that are able to be used by decorator to create the custom products. The system receives a customization option and an order file type in the custom order. The system or a third party evaluates that customization option to identify a change order that is required and also determines a conversion recommendation to convert the order file type or a production-ready file type. The production-ready custom order is generated based on the change order and the conversion recommendation.

Abstract: Presented here is an audio device, such as a headphone, that can create, maintain and use secure data. The secure data can include an amount of time that the user has used the audio device and/or an amount of time allocated to the user. When the amount of time the user has used the audio device exceeds the amount of time allocated to the user, the audio device can stop emitting the audio. The secure data can also include a hearing profile of the user, which ca uniquely identify the user. The secure data associated with the headphone can be encrypted to prevent tampering.

Abstract: A cassette for holding fluid path components for a fluid injector may include a body defining at least one feature for holding at least one fluid path component for the fluid injector; and a connecting member for removably connecting the body of the cassette to the fluid injector, the connecting member operatively connected to the body, wherein the connecting member comprises at least one pivotable connecting feature protruding from the body, and wherein each of the at least one pivotable connecting feature is configured for removably connecting to a corresponding connecting feature receiver on the fluid injector such that the body is pivotally movable relative to the fluid injector between a first, unlatched position and a second, latched position in which the at least one fluid path component on the body of the cassette is positioned for operative connection to a corresponding feature of the fluid injector.

Abstract: Systems and methods are provided for collecting eye-gaze data for training an eye-gaze prediction model. The collecting includes selecting a scan path passing through a series of regions of a grid on a screen of a computing device, moving a symbol as an eye-gaze target along the scan path, and receiving facial images at eye-gaze points. The eye-gaze points are uniformly distributed within the respective regions. Areas of the regions that are adjacent to edges and corners of the screen are smaller than other regions. The difference in areas shifts centers of the regions toward the edges, density of data closer to the edges. The scan path passes through locations in proximity to the edges and corners of the screen for capturing more eye-gaze points in the proximity. The methods interactively enhance variations of facial images by displaying instructions to the user to make specific actions associated with the face.

Abstract: Compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification, as are uses of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

Abstract: Presented herein are techniques for monitoring the insertion of an intra-cochlear stimulating assembly for the occurrence of one or more insertion stop conditions. The insertion stop conditions are detectable events indicating that movement of the stimulating assembly into a recipient's cochlea should be at least temporarily stopped. The insertion monitoring is based on objectively measured inner ear potentials, such as acoustically-evoked potentials.

Abstract: Introduced here are systems and methods to increase accuracy of speech recognition by utilizing multiple sensors placed at multiple speech transmission regions such as a user's lips, throat, ear canal, etc. The various speech transmission regions are better at transmitting certain phonemes, and a sensor placed close to a particular speech transition region can more accurately detect the phoneme transmitted through the particular speech transmission region. For example, a microphone placed close to the lips can better detect labial phonemes such as m, n, p, and b, than a microphone placed close to the throat. Further, disclosed here are ways to reduce energy consumption while performing speech recognition.