Abstract: An irrigation attachment system for automated or autonomous delivery of lawn-treatment solutions through an existing sprinkler network is disclosed. The system includes an in-ground housing containing a refillable reservoir of concentrated pesticide or fertilizer, a mixing unit coupled downstream of a water supply line, and an electronic control unit programmed with a watering schedule and treatment concentration ratio. During operation, the mixing unit selectively withdraws treatment solution from the reservoir and outputs a treated water and solution mixture through sprinkler heads. The control unit includes memory for storing operational instructions, a processor to regulate dosing events in accordance with user-defined parameters, and a wireless communication module to interface with a mobile device. A day-of-week scheduling interface enables remote configuration of flow percentages and treatment add-in ratios.

Abstract: The present invention relate to autologous isolated unpolarized human macrophages for use in the treatment of liver disease and macrophages for use in a method of treating fibrosis in a human in need thereof.

Abstract: The present invention relate to autologous isolated unpolarized human macrophages for use in the treatment of liver disease and macrophages for use in a method of treating fibrosis in a human in need thereof.

Abstract: An apparatus and method is disclosed for forming an item in a mould using a casting process, typically a counter gravity casting system. Heating assembly, transfer assembly and mould filling assembly can be used in combination. The transfer assembly includes apparatus and method for removing sedimentation from the liquid metal and/or metal alloy received from the heating assembly and extracting the same prior to the metal and/or metal alloy reaching the mould filling assembly at which the same is supplied to fill a cavity of a mould and which, once filled, can be slid to a location to cool and thereby make available the mould filling assembly for the next mould to be filled. This apparatus and method provide an efficient, high throughput system, along with high quality cast items.

Abstract: Disclosed herein are systems and methods for setting, accessing, and modifying user privacy settings using a distributed ledger. In an aspect, a system can search previously stored software contracts to locate an up-to-date version of a software contract associated with a user based on a request for access to user data for the particular user. Then, the system determines that the user data is permitted to be shared. The system transmits, to a data virtualization platform, instructions to extract encrypted user data from a data platform. The system can then make available, to a data verification system, a private encryption key and details associated with the software contract to verify that the private encryption key and the user data match. Then the system transmits, to the data virtualization platform, the private encryption key so that the data virtualization platform can decrypt the encrypted user data.

Abstract: Compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification, as are uses of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

Abstract: Disclosed herein are systems and methods for setting, accessing, and modifying user privacy settings using a distributed ledger. In an aspect, a system can search previously stored software contracts to locate an up-to-date version of a software contract associated with a user based on a request for access to user data for the particular user. Then, the system determines that the user data is permitted to be shared. The system transmits, to a data virtualization platform, instructions to extract encrypted user data from a data platform. The system can then make available, to a data verification system, a private encryption key and details associated with the software contract to verify that the private encryption key and the user data match. Then the system transmits, to the data virtualization platform, the private encryption key so that the data virtualization platform can decrypt the encrypted user data.

Abstract: The development of the method of the invention enables the efficient and reproducible production of genetically modified GMP-grade human macrophages. The inventors have described the effects of the method described on cell viability and efficiency of introduction of genetic material into macrophages. Unlike previous methods of introducing genetic material into macrophages, excellent conditions are demonstrated which produce efficient transgene expression, without compromising cell viability. Critically, the method of the invention does not use virus to introduce genetic material, is efficacious on mature cells, are functional with in vitro assay and in vivo transfer in a liver disease model and complies with practices compatible with manufacture and delivery of these cells to patients.

Abstract: The improved 4-5 day, optionally 3-5 day GMP-compliant in-vitro method enables the production of macrophages from monocytes that benefits from a shorter cell culture time, fewer interventions whilst maintaining the desired characteristics of the human macrophages. The present invention describes a method wherein the monocytes are cultured in medium comprising one or more growth actors to stimulate macrophages with a pro-regenerative phenotype. The method described herein is xeno-free, serum-free and GMP compliant. In addition, further disclosed are macrophages produced according to the present invention and the use of said macrophages in the treatment of liver diseases, such as liver cirrhosis.

Abstract: Natural gestures for interacting with spreadsheet documents are provided. A user may interact with a spreadsheet document using a variety of touch-based gestures. Gestures applied to a spreadsheet document may be used for making structural and display changes to the document. For example, gestures may be used on the spreadsheet document for inserting new columns and rows; for revealing hidden columns and rows; for deleting columns and rows; for extending functionalities across columns and rows; for moving objects displayed in a spreadsheet document; and for navigating various parts of a spreadsheet document.

Abstract: The present invention relates to a method of improving the viability of macrophages subjected to cryopreservation, particularly for macrophages which are to be used in therapy, wherein the method comprises a step of maintaining the macrophages at a temperature of 2-12° C. for at least 30 minutes during either freezing or thawing procedures. Following the holding step during cooling, a cooling rate of 1 to 5° C. is used until the macrophages in a medium are frozen. For thawing the macrophages, a warming rate of 1 to 5° C. per minute is used until a temperature of 35-37° C. is reached. The present invention further relates to the cryopreserved macrophages, and the thawed macrophages produced by such methods. The technique may provide macrophages that are GMP-compliant and have a viability of at least 60%.

Abstract: Described herein are CpG-adjuvanted SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

Abstract: The present disclosure describes a value referred to as a compound object that stores multiple values in a single cell, wherein those multiple values are organized according to a defined structure. The compound object may store multiple values according to a known defined data structure such as, for example, a record, vector, matrix, table, or array. In other embodiments, the compound object may store multiple values as any nested combination of any one of the known or user-defined data structures. Each of the values stored in the compound object are individually referenceable and can fully participate with spreadsheet functionality including calculations, referencing, and formatting.

Abstract: The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

Abstract: Described herein are CpG-adjuvanted SARS-CoV-2 vaccines and compositions and methods of producing and administering said vaccines to subjects in need thereof.

Abstract: An apparatus and method is disclosed for forming an item in a mould using a casting process, typically a counter gravity casting system. Heating assembly, transfer assembly and mould filling assembly can be used in combination. The transfer assembly includes apparatus and method for removing sedimentation from the liquid metal and/or metal alloy received from the heating assembly and extracting the same prior to the metal and/or metal alloy reaching the mould filling assembly at which the same is supplied to fill a cavity of a mould and which, once filled, can be slid to a location to cool and thereby make available the mould filling assembly for the next mould to be filled. This apparatus and method provide an efficient, high throughput system, along with high quality cast items.

Abstract: Text messages are used to interact with objects in a spreadsheet. For example, text messages may be used to enter/receive data in the spreadsheet. One or more text messages may be associated with a spreadsheet. Text messages may be associated with cells, tables, charts and other objects of the spreadsheet. When the spreadsheet receives a text message, the text message is parsed and information that is contained within the text message is used to interact with one or more objects within the spreadsheet. The spreadsheet may also generate and send text messages that provide information about the spreadsheet and/or request information to be entered within the spreadsheet. For example, the spreadsheet may send out an update of one or more values/objects within a spreadsheet and/or send a request within a text message requesting information to update a table.

Abstract: Disclosed herein are systems and methods for setting, accessing, and modifying user privacy settings using a distributed ledger. In an aspect, a system can search previously stored software contracts to locate an up-to-date version of a software contract associated with a user based on a request for access to user data for the particular user. Then, the system determines that the user data is permitted to be shared. The system transmits, to a data virtualization platform, instructions to extract encrypted user data from a data platform. The system can then make available, to a data verification system, a private encryption key and details associated with the software contract to verify that the private encryption key and the user data match. Then the system transmits, to the data virtualization platform, the private encryption key so that the data virtualization platform can decrypt the encrypted user data.

Abstract: A system and method for juror selection tracking and analysis in a juror-tracking app interface. The method can include displaying on an electronic device's display screen a bounded area and selectable juror icons positioned therein, representing a courtroom and prospective jurors therein, respectively. The juror icons can be selectable, rotatable, and relocatable within the bounded area to mimic the courtroom configuration. The juror-tracking app interface can also display questions and corresponding selectable answers to track answers given by each of the prospective jurors. Points associated with each of the selectable answers can also be added to a running total of points for each of the prospective jurors displayed on a juror list or otherwise associated with the juror icons. Statuses of the prospective jurors (such as request or grant of a peremptory strike) can be selected from a menu and graphically displayed onto each of the corresponding juror icons.

Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.