Abstract: Embodiments include humanized anti-LGR5 antibodies for the treatment of cancer. Some embodiments include antibodies which may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Some embodiments include heavy and light chain polypeptide sequences for the binding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.

Abstract: Disclosed herein is an apparatus for containing and dispensing reagent into a microfluidic cartridge for use in sample-to-answer or point-of-care instruments. The apparatus contains a reagent dispensing unit, such as a reagent blister. The blister can contain one or more vessels for containment of reagents and a rupturable seal that blocks the flow of reagent from the reagent blister through an interface and into the microfluidic cartridge.

Abstract: Systems and methods are provided for collecting eye-gaze data for training an eye-gaze prediction model. The collecting includes selecting a scan path passing through a series of regions of a grid on a screen of a computing device, moving a symbol as an eye-gaze target along the scan path, and receiving facial images at eye-gaze points. The eye-gaze points are uniformly distributed within the respective regions. Areas of the regions that are adjacent to edges and corners of the screen are smaller than other regions. The difference in areas shifts centers of the regions toward the edges, density of data closer to the edges. The scan path passes through locations in proximity to the edges and corners of the screen for capturing more eye-gaze points in the proximity. The methods interactively enhance variations of facial images by displaying instructions to the user to make specific actions associated with the face.

Abstract: A cassette for holding fluid path components for a fluid injector may include a body defining at least one feature for holding at least one fluid path component for the fluid injector; and a connecting member for removably connecting the body of the cassette to the fluid injector, the connecting member operatively connected to the body, wherein the connecting member comprises at least one pivotable connecting feature protruding from the body, and wherein each of the at least one pivotable connecting feature is configured for removably connecting to a corresponding connecting feature receiver on the fluid injector such that the body is pivotally movable relative to the fluid injector between a first, unlatched position and a second, latched position in which the at least one fluid path component on the body of the cassette is positioned for operative connection to a corresponding feature of the fluid injector.

Abstract: The disclosed end-to-end product customization systems and methods receive custom orders from customers or consumers, evaluate them, and generate production-ready custom orders that are able to be used by decorator to create the custom products. The system receives a customization option and an order file type in the custom order. The system or a third party evaluates that customization option to identify a change order that is required and also determines a conversion recommendation to convert the order file type or a production-ready file type. The production-ready custom order is generated based on the change order and the conversion recommendation.

Abstract: Presented here is an audio device, such as a headphone, that can create, maintain and use secure data. The secure data can include an amount of time that the user has used the audio device and/or an amount of time allocated to the user. When the amount of time the user has used the audio device exceeds the amount of time allocated to the user, the audio device can stop emitting the audio. The secure data can also include a hearing profile of the user, which ca uniquely identify the user. The secure data associated with the headphone can be encrypted to prevent tampering.

Abstract: Compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification, as are uses of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

Abstract: Presented herein are techniques for monitoring the insertion of an intra-cochlear stimulating assembly for the occurrence of one or more insertion stop conditions. The insertion stop conditions are detectable events indicating that movement of the stimulating assembly into a recipient's cochlea should be at least temporarily stopped. The insertion monitoring is based on objectively measured inner ear potentials, such as acoustically-evoked potentials.

Abstract: Introduced here are systems and methods to increase accuracy of speech recognition by utilizing multiple sensors placed at multiple speech transmission regions such as a user's lips, throat, ear canal, etc. The various speech transmission regions are better at transmitting certain phonemes, and a sensor placed close to a particular speech transition region can more accurately detect the phoneme transmitted through the particular speech transmission region. For example, a microphone placed close to the lips can better detect labial phonemes such as m, n, p, and b, than a microphone placed close to the throat. Further, disclosed here are ways to reduce energy consumption while performing speech recognition.

Abstract: Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.

Abstract: Disclosed herein are systems and methods for setting, accessing, and modifying user privacy settings using a distributed ledger. In an aspect, a system can search previously stored software contracts to locate an up-to-date version of a software contract associated with a user based on a request for access to user data for the particular user. Then, the system determines that the user data is permitted to be shared. The system transmits, to a data virtualization platform, instructions to extract encrypted user data from a data platform. The system can then make available, to a data verification system, a private encryption key and details associated with the software contract to verify that the private encryption key and the user data match. Then the system transmits, to the data virtualization platform, the private encryption key so that the data virtualization platform can decrypt the encrypted user data.

Abstract: A system and method for providing video conferencing are described herein. Original video streams from one or more cameras are sampled to form downscaled versions of the video stream. The downscaled version is analyzed to find regions of interest and generate metadata describing aspects of the regions of interest, including a region that includes a preferred speaker and the best view of each participant present together in the video conference. Cropping instructions are generated from the metadata, and portions of the original video stream are removed to form a set of presentation views for each participant, including the preferred speaker. The set of presentation views is stitched together to form a composite display for each participant viewing the stream remotely.

Abstract: A fiber optic telecommunications device includes a frame and a fiber optic module including a rack mount portion, a center portion, and a main housing portion. The rack mount portion is stationarily coupled to the frame, the center portion is slidably coupled to the rack mount portion along a sliding direction, and the main housing portion is slidably coupled to the center portion along the sliding direction. The main housing portion of the fiber optic module includes fiber optic connection locations for connecting cables to be routed through the frame. The center portion of the fiber optic module includes a radius limiter for guiding cables between the main housing portion and the frame, the center portion also including a latch for unlatching the center portion for slidable movement. Slidable movement of the center portion with respect to the rack mount portion moves the main housing portion with respect to the frame along the sliding direction.

Abstract: Introduced here is a wearable audio system including modular ear-cup and ear-bud that can be attached and detached to the user together, or independently of each other. Further, the modular ear-cup and ear-bud can operate together, or independently of each other. The wearable audio system can perform active noise cancellation by measuring noise inside the ear-cup and/or the ear-bud, computing the noise canceling sound, and forwarding the noise canceling sound to a speaker inside the ear-cup and/or the ear-bud. The wearable audio system can be wirelessly charged while operating, thus allowing the user to continuously listen to music more than previously possible. The wearable audio system can optimize power consumption by redistributing power intensive tasks to power sources with the highest amount of power. Further, the ambient sound outside the ear-cup can be measured and played by the speakers in the earbud allowing the user to hear the surrounding environment.

Abstract: A system may include an external device configured to transmit a first audio data to an ear-bud. A system may include the ear-bud configured to be positioned within an ear canal of a user, the ear-bud comprising: a microphone configured to generate audio data responsive to detecting audio, a storage device, configured to store computer-executable instructions; and one or more processors in communication with the storage device, wherein the computer-executable instructions, when executed by the one or more processors, cause the one or more processors to: receive the first audio data from the external device, receive a second audio data from the microphone, estimate an acoustic environment based on the first audio data and the second audio data, generate a third audio data based on the acoustic environment, and cause a speaker to emit the third audio data.

Abstract: Disclosed are systems and methods for document branching. In some embodiments, the method includes the steps of: obtaining a branch model associated with a set of related documents, the branch model comprising one or more branches, each branch of the one or more branches comprising a branch type and one or more nodes, the one or more branches comprising a primary branch associated with a primary document, the set of related documents comprising the primary document having a first document identifier; generating a secondary branch based upon a revision of the primary document, the secondary branch associated with a secondary document of the set of related documents, the secondary document having a second document identifier; and adding the secondary branch to the branch model.

Abstract: A powered fluid injector including an assembly for retaining a pressure jacket and a syringe on a fluid injector is provided. The assembly includes a base plate comprising a body; a first retaining arm and a second retaining arm operatively mounted on the body of the base plate, wherein the first retaining arm have a first retaining surface and the second retaining arm having a second retaining surface. The first retaining surface and the second retaining surface abut a distal surface of at least one of the pressure jacket and the syringe. The assembly also includes a linkage assembly connected to at least one of the first retaining arm and/or the second retaining arm to move the retaining arms between at least a first open position and a closed position.

Abstract: Methods and systems for additive manufacturing are provided. An exemplary method includes calculating a slice area distribution of a desired 3D design including slice areas of slices of the desired design, wherein the slices have an initial slice area differential. The method further includes obtaining a slice area distribution of a sacrificial 3D design comprising slice areas of slices of the sacrificial design. The method includes planning a 3D layout of the desired and sacrificial design, wherein at each respective parallel plane in the layout a total slice area includes a respective slice area of the desired design and a respective slice area of the sacrificial design, and wherein the layout has a total slice area differential that is less than the initial slice area differential. Also, the method includes generating instructions for printing slices of the desired design and the sacrificial design according to the layout.