Abstract: The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract: A system and method for presenting a skippable pre-roll interactive advertisement (e.g., a pre-roll video). The interactive advertisement is configured to be presented in advance of content requested by a user and convey a brand message to a user while at the same time providing the user with an associated type-in challenge (i.e., a challenge or question relating to the pre-roll advertisement) which, if answered appropriately, allows the user to skip or bypass the pre-roll advertisement and advance to the desired content. The user response to the interactive advertisement may be collected and utilized to generate marketing reports which illustrate the effectiveness of an interactive advertisement in conveying an advertiser's message.

Abstract: Compounds of Formula 1 where the variables have the meaning defined in the specification are used to activate alpha2 adrenergic receptors. The compounds of Formula 1 are incorporated in pharmaceutical compositions and are used as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors.