Abstract: This is a method and device for removing metal or depositing metal from the base metal of a vessel or performing crack and/or defect removal via excavation or other machine work in situ on cylindrical or other surfaces. In a one embodiment, the method and device is used for removing bonded alloy from carbon steel substrate in-situ. In one embodiment, the inventive system and method is used inside a coker unit to remove existing cladding along the weld seams and to prepare the machined area for application of new weld metal. In one embodiment, the method and device is used to deposit weld metal on a surface or in a groove. In one or more embodiments, the groove weld is then inspected for defects and repaired by the device, if required. In one or more embodiments, mapping is performed to autonomously direct the device.

Abstract: The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract: A system and method for presenting a skippable pre-roll interactive advertisement (e.g., a pre-roll video). The interactive advertisement is configured to be presented in advance of content requested by a user and convey a brand message to a user while at the same time providing the user with an associated type-in challenge (i.e., a challenge or question relating to the pre-roll advertisement) which, if answered appropriately, allows the user to skip or bypass the pre-roll advertisement and advance to the desired content. The user response to the interactive advertisement may be collected and utilized to generate marketing reports which illustrate the effectiveness of an interactive advertisement in conveying an advertiser's message.

Abstract: Compounds of Formula 1 where the variables have the meaning defined in the specification are used to activate alpha2 adrenergic receptors. The compounds of Formula 1 are incorporated in pharmaceutical compositions and are used as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors.