Abstract: Compact packages including microelectromechanical system (MEMS) devices and multiple application specific integrated circuits (ASICs) are described. These packages are sufficiently small to be applicable to contexts in which space requirements are particularly strict, such as in consumer electronics. These packages involve vertical die stacks. A first ASIC may be positioned on one side of the die stack and another ASIC may be positioned on the other side of the die stack. A die including a MEMS device (e.g., an accelerometer, gyroscope, switch, resonator, optical device) is positioned between the ASICs. Optionally, an interposer serving as cap substrate for the MEMS device is also positioned between the ASICs. In one example, a package of the types described herein has an extension of 2 mm×2 mm in the planar axes and less than 500-800 ?m in height.

Abstract: One embodiment provides an apparatus comprising a memory stack including multiple memory dies and a parallel processor including a plurality of multiprocessors. Each multiprocessor has a single instruction, multiple thread (SIMT) architecture, the parallel processor coupled to the memory stack via one or more memory interfaces. At least one multiprocessor comprises a multiply-accumulate circuit to perform multiply-accumulate operations on matrix data in a stage of a neural network implementation to produce a result matrix comprising a plurality of matrix data elements at a first precision, precision tracking logic to evaluate metrics associated with the matrix data elements and indicate if an optimization is to be performed for representing data at a second stage of the neural network implementation, and a numerical transform unit to dynamically perform a numerical transform operation on the matrix data elements based on the indication to produce transformed matrix data elements at a second precision.

Abstract: The present disclosure describes various improvements for programmable nuclease-based detection assays. Also provided are compositions, methods, kits, systems, and devices for practicing the same. Such improvements include improved reporter designs to facilitate the cleavage of a reporter immobilized on a substrate by an activated programmable nuclease. Improved reporter designs may comprise various lengths and structures of the reporter. The substrate can also comprise immobilized guide nucleic acids and/or programmable nucleases.

Abstract: Disclosed herein is a method of treating Idiopathic Pulmonary Fibrosis (IPF). The method includes administering to a subject in need thereof the deuterium-enriched pirfenidonc LYT-100 at a total daily dose from about 1650 mg to about 2500 mg.

Abstract: A composite can include cellulose fiber; and foam binding the cellulose fiber. A method for manufacturing a composite can comprise mixing a plurality of ingredients to form a pre-foam mixture; foaming the pre-foam mixture to produce a foam; mixing the foam with cellulose fiber to form a composite material; and curing the composite material.

Abstract: Techniques are described for generating a composite display of multiple user interface elements, each of which presents datasets corresponding to the operational parameters of computing resources even though the computer resources may operate in different computing environments. In some cases, the composite display includes a feature that enables a comparison of operational performance data between a target measurement period relative to a selectable reference period. The reference period may be manually selectable from a menu of candidate time periods or identified and/or selected by the system based on a similarity between data characteristics in the target measurement period and a baseline measurement period.

Abstract: An optical film includes a plurality of alternating first and second polymeric layers, such that the first polymeric layers have a smaller average in-plane index of refraction than the second polymeric layers and the first polymeric layers have a glass transition temperature of at least 107 deg. C. The optical film may be a reflective polarizer. An optical stack includes a linear absorbing polarizer and the reflective polarizer disposed on, and bonded to, the absorbing polarizer. The reflective polarizer has an optical reflectance of at least 60% for a first polarization state and an optical transmittance of at least 60% for an orthogonal second polarization state. When heated at 105 deg. C. for 15 minutes, a difference in shrinkage of the reflective polarizer and the absorbing polarizer along the first and second polarization states is greater than about zero and 0.2%, respectively.

Abstract: Historical sleep metrics are accessed. Historical sensor data is accessed. Incidences of low quality sleep experienced by the user are identified. Particular environmental conditions that affected the user during the incidences of low quality sleep are identified. A corrective plan that specifies a change to an environmental control system to reduce the particular environmental conditions is created. The behavior of the environmental control system is modified such that the environmental control system reduces the particular environmental conditions when the user sleeps in the bed.

Abstract: Expandable hip stem implants, systems, and methods of implanting a hip stem during a hip arthroplasty are provided. The implant may include a proximal body having a neck terminating at a free end, a distal stem having a proximal portion coupled to the proximal body and a distal portion, and a plurality of expandable bodies aligned around the distal stem. The plurality of expandable bodies have a collapsed configuration and an expanded configuration such that the plurality of expandable bodies expand radially outward away from one another.

Abstract: A golf club head including a face defining a loft plane, a rear, and a crown, the crown having a turbulator comprising a plurality of ridges. Each ridge includes a front surface having a first end nearest the face, a second end nearest the ridge apex, and a rear surface nearest the rear portion of the club head. The turbulator is positioned in a forward two-fifths portion of the crown in a front end to a rear end direction. The ridge apex of each ridge is positioned within the first 50% of the ridge length.

Abstract: A memory instance comprises a plurality of banks of storage cells to store data values, and input/output circuitry shared between the plurality of banks for receiving write data or outputting read data. Each bank of storage cells supports a power saving mode and an operational mode. A control interface receives power control signals for controlling use of the power saving mode. Bank power control circuitry individually controls, for each of a plurality of subsets of banks of storage cells within the same memory instance, whether that subset of banks is in the power saving mode based on the power control signals. For at least one setting for the power control signals, one subset of banks is in the power saving mode while another subset of banks in the same memory instance is in the operational mode. Also disclosed is power control circuitry which selects the power mode to use for each subset of banks and generates the power control signals.

Abstract: A force sensor includes: a dielectric elastic base material; and a first electrode and three second electrodes that sandwich the elastic base material from both sides in a thickness direction. In a plan view seen along the thickness direction, the three second electrodes are arranged to overlap portions of the first electrode that are different from one another. In each case where an external force acts on the elastic base material along each of a first direction and a second direction that form a predetermined angle on a plane orthogonal to the thickness direction, among areas of the portions where each of the three second electrodes overlaps the first electrode, the areas corresponding to at least two of the second electrodes change.

Abstract: Methods and systems for structuring, storing and displaying time series data in a user interface. One system includes processors executing instructions to determine, from time series data from a first sensor, a first subset of time series data for the first batch from the first start time and the first end time, determine, from the time series data from the first sensor, a second subset of time series data for the second batch from the second start time and the second end time, generate a time series user interface comprising a chart, the chart including a first plot for the first subset of time series data and a second plot for the second subset of time series data, the first plot being aligned to the second plot, and cause presentation of the time series user interface.

Abstract: Medical devices and related methods are described, including a medical device that includes a handle including a housing. The housing may include a grip and an actuator. The handle may further include an imaging module including a printed circuit board, and a laser module including a first laser source configured to couple to a first laser fiber and a second laser source configured to couple to a second laser fiber. The laser module and the imaging module may be contained within the housing or the imaging module, the laser module, or both the imaging module and the laser module may be selectively attachable to and detachable from the housing.

Abstract: Methods and systems for determining clock signals for audio processing using different operating modes are provided. In one aspect, a transition control word is determined to transition from a first control word for a first operating mode to a second control word for the second operating mode. The transition control word may be used to process the received audio signal while transitioning between the operating modes. After the transition, the second control word may be used to process the received audio signal using the second operating mode. The transition control word may be used to transition between various aspects of the operating modes, including different frequencies or resolutions, control systems, power levels, and more.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: The present application relates to azaaromatic amide derivatives for the treatment of cancer. Specifically, the present application relates to a preparation method and use of azaaromatic amide derivatives. The present application relates to azaaromatic amide derivatives and anilino-pyrimidine compounds represented by formula (I), formula (II), formula (III), formula (IV), and formula (V), and pharmaceutically acceptable salts thereof; the compounds or salts thereof can be used to treat or prevent a disease or disorder by regulating certain mutant forms of epidermal growth factor receptors. The present application also relates to a pharmaceutical composition comprising the compounds or salts thereof, and a method for treating various diseases mediated by EGFR, or HER2, or HER4 by using the compounds and salts thereof.

Abstract: Systems, methods, and devices for providing a comfort dashboard are described herein. One method includes receiving operational data associated with an HVAC system of a facility, receiving credentials associated with a user of a user device including a number of display elements configurable by the user, and determining a particular portion of the operational data to provide to the user via the display elements of the user device based, at least in part, on the credentials.

Abstract: Aspects and embodiments herein pertain to global ML prediction applied in a data security context. In some examples, a global prediction pertaining to a data item as a whole (the ‘original’ data item) is generated using an ML predictor. A data element is masked by removing it from the data item, or obscuring it in some way (e.g., through modification or replacement). The same ML predictor is applied to the perturbed data item. A change in global confidence between the original data item and the perturbed data item denotes local significance of the individual data item (or subset of data items) that have been masked. Other significance indicators (such as start and end markers of significant sections) are also considered. Other methods of estimating local significance are considered. In some examples, one or more such methods are used to generate training data for training a self-interpretation ML model.

Abstract: On or more examples relate, generally, to an apparatus that includes a reconciliation sublayer of a physical layer, a reduced media independent interface (RMII) of the physical layer, and a logic circuit. Such a logic circuit may operate to receive a changed carrier sense signal provided by the reconciliation sublayer, generate a further changed carrier sense signal at least partially responsive to a prediction that the changed carrier sense signal would cause unintended signaling at the RMII, and provide the further changed carrier sense signal to the RMII.