Abstract: New nicotinic acid glycerol ester compound(s) (NAEs); topical personal care compositions containing NAEs; and methods for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of one or more of the nicotinic acid glycerol ester compounds for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of a skin benefit agent comprising certain nicotinic acid glycerol ester compounds in the manufacture of a topical personal care composition for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described.

Abstract: Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and S-adenosyl-L-methionine. Use of niacinamide and S-adenosyl-L-methionine in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.

Abstract: Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in the cells of an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and of one or more cooperative skin benefit agents for reducing cellular mitochondrial fragmentation, which cooperative agents are selected from the group consisting of 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof. Use of niacinamide and cooperative skin benefit agent selected from 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.

Abstract: The invention provides a method for obtaining information useful to determine the effect of the use of sun protection products on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg

Abstract: New nicotinic acid glycerol ester compound(s) (NAEs); topical personal care compositions containing NAEs; and methods for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of one or more of the nicotinic acid glycerol ester compounds for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described. Use of a skin benefit agent comprising certain nicotinic acid glycerol ester compounds in the manufacture of a topical personal care composition for modulating or activating cellular AMPK levels; and for increasing skin cellular bioenergetics are described.

Abstract: Certain novel substituted 3-(phenoxymethyl) benzyl amines and personal care compositions comprising such, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.

Abstract: Skin care compositions comprising certain phenoxyalkylamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.

Abstract: Certain novel substituted 3-(phenoxymethyl) benzyl amines and personal care compositions comprising such, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.

Abstract: Skin care compositions comprising certain phenoxyalkylamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.