Patents by Inventor John Chute

John Chute has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Signatures of radiation response
    Patent number: 10316365
    Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: June 11, 2019
    Assignee: Duke University
    Inventors: John Chute, Joseph Nevins, Holly Dressman, Nelson Chao
  • SIGNATURES OF RADIATION RESPONSE
    Publication number: 20140243226
    Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
    Type: Application
    Filed: November 27, 2013
    Publication date: August 28, 2014
    Applicant: Duke University
    Inventors: John Chute, Joseph Nevins, Holly Dressman, Nelson Chao
  • SIGNATURES OF RADIATION RESPONSE
    Publication number: 20110028338
    Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
    Type: Application
    Filed: April 2, 2009
    Publication date: February 3, 2011
    Inventors: John Chute, Joseph Nevins, Holly Dressman, Nelson Chao
  • Ex-vivo rescue of hematopoietic stem cells after lethal irradiation
    Publication number: 20060039895
    Abstract: A method of autologous rescue of an individual exposed to a harmful hematopoietic stem cell condition is described. The method includes removing hematopoietic stem cells from the individual, culturing the hematopoietic stem cells and reintroducing cultured hematopoietic stem cells into the individual. Stem cells are grown in a stromal-cell free medium. The harmful condition can be radiation. The culture medium can contain any of several growth stimulating factors.
    Type: Application
    Filed: January 31, 2005
    Publication date: February 23, 2006
    Applicant: LARGE SCALE BIOLOGY CORPORATION
    Inventor: John Chute
  • Ex-vivo rescue of transplantable hematopoietic stem cells following myeloablative injury
    Publication number: 20040151700
    Abstract: An ex-vivo method of treating myeloablation of hematopoietic stem and progenitor cells, particularly myeloablation due to ionizing radiation is disclosed. An ex-vivo method of restoring a depleted population of rapidly proliferating hematopoietic stem cells is also disclosed. The methods comprise co-culturing resistant hematopoietic stem cells in a culture medium comprising a monolayer of endothelial cells and various cytokines. Bone marrow stem cells harvested from animals exposed to 1050 cGy were incapable of providing hematopoietic recovery in secondary irradiated recipients. Bone marrow stem cells harvested from animals exposed to 1050 cGy and then co-cultured×10 days with endothelial cell monolayers showed complete recovery of hematopoietic repopulating capacity which was equivalent to normal BM stem cells.
    Type: Application
    Filed: October 30, 2002
    Publication date: August 5, 2004
    Inventors: David M. Harlan, Thomas Davis, John Chute