Abstract: A method for preparing an aqueous suspension may include providing a fibrous substrate comprising cellulose having a Canadian Standard freeness equal to or less than 450 cm3, and microfibrillating the fibrous substrate in an aqueous environment by grinding in the presence of a grinding medium consisting essentially of mullite. The grinding may be carried out in the absence of grindable inorganic particulate material. The grinding medium may be present in an amount of at least about 10% by volume of the aqueous environment. The microfibrillated cellulose may have a fibre steepness of from about 20 to about 50.

Abstract: A head-worn see-through display includes a display panel adapted to generate image content light, a combiner adapted to reflect the image content light towards an eye of a user, wherein the combiner transmits scene light from a surrounding environment to the eye of the user, and an image expansion optic intermediate the display panel and the combiner. The image expansion optic includes a flat partially reflective and partially reflective surface (the “flat surface”), a curved partially reflective and partially reflective surface (the “curved surface”), and the flat surface adapted to reflect the image content light towards the curved surface and the curved surface adapted to reflect the image light back towards the flat surface, wherein the image light transmits through the flat surface towards the combiner.

Abstract: The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns. Further provided herein are methods of designing, making, and using the cancer assay panel for the diagnosis of cancer.

Abstract: The use of pectins and/or polymers to prevent nicotine oxidation in tobacco containing products is disclosed. These polymers may be naturally occurring anionic polymers or synthetic polymers. These pectins and/or polymers prevent nicotine from oxidizing into cotinine, nicotine-cis-N-oxide, nicotine-trans-N-oxide, and/or nicotine-1,1-di-N-oxide. Molluscicides, algaecides, pesticides, and stabilized nicotine compositions comprising nicotine and pectin, anionic polymers, or combinations thereof are disclosed.

Abstract: A microcurrent migraine treatment device includes an adaptive trigger circuit configured to dynamically determine a triggering threshold for applying a therapeutic microcurrent via a treatment electrode to a treatment location on a person's skin for treatment of a migraine condition.

Abstract: A microcurrent temporomandibular joint (TMJ) symptom treatment device includes an adaptive trigger circuit configured to dynamically determine a triggering threshold for applying a therapeutic microcurrent via a treatment electrode to a treatment location on a person's skin for treatment of a TMJ symptom.

Abstract: A temporomandibular joint (TMJ) disorder microcurrent treatment device and methods of operating the microcurrent device that includes a treatment electrode and at least one return electrode. The TMJ microcurrent treatment device may output and maintain a constant current treatment waveform.

Abstract: A magnetically driven pressure generator including a housing, flexible member, first magnetic force generator, and second magnetic force generator. The magnetically driven pressure generator oscillates the flexible member to increase or decrease the volume of a chamber, inversely increasing or decreasing the pressure of the chamber.

Abstract: Unitary measuring pipettes include a tubular body of biaxially oriented thermoplastic material, together with size reduction, elimination, and/or reorientation of longitudinally spaced, raised circumferential witness features, to mitigate or avoid interference between such witness features and graduated volumetric markings on an outside surface of the tubular body. Methods and apparatus for vacuum forming of unitary measuring pipettes are also provided. Gas permeable apertures or pores having a maximum width of no greater than 150 microns, in ranges of 10-100 microns, 10-50 microns, or subranges thereof, may be defined in face plates or inserts received by mold blanks, or defined in molding surface of cooperating mold bodies, and may be used to produce a tubular pipette body having reduced height witness features. Cooperating mold bodies may each be produced from multiple mold body sections with gas passages defined therein and/or therebetween.

Abstract: Unitary measuring pipettes include a tubular body of biaxially oriented thermoplastic material, together with size reduction, elimination, and/or reorientation of longitudinally spaced, raised circumferential witness features, to mitigate or avoid interference between such witness features and graduated volumetric markings on an outside surface of the tubular body. Methods and apparatus for vacuum forming of unitary measuring pipettes are also provided. Gas permeable apertures or pores having a maximum width of no greater than 150 microns, in ranges of 10-100 microns, 10-50 microns, or subranges thereof, may be defined in face plates or inserts received by mold blanks, or defined in molding surface of cooperating mold bodies, and may be used to produce a tubular pipette body having reduced height witness features. Cooperating mold bodies may each be produced from multiple mold body sections with gas passages defined therein and/or therebetween.

Abstract: Methods of preparing partially dried or essentially completely dried compositions comprising microfibrillated cellulose and an inorganic particulate material may include microfibrillating a fibrous substrate comprising cellulose in an aqueous environment by grinding in the presence of an inorganic particulate material to form an aqueous composition comprising microfibrillated cellulose and inorganic particulate material, wherein the fibrous substrate comprising cellulose has a Canadian Standard freeness equal to or less than 450 cm, wherein the fibrous substrate to the inorganic particulate material are in a ratio of about 99.5:0.5 to about 0.5:99.

Abstract: The present invention relates to compositions and methods for coating paper products

Abstract: The present invention relates to compositions, such as filled and coated papers, comprising microfibrillated cellulose and inorganic particulate material.

Abstract: A sinus treatment device and methods of operating the sinus treatment device that include an enhanced conductive tip and at least one return electrode are disclosed.

Abstract: Measuring pipettes including integral or encapsulated filters, as well as methods and apparatuses for forming the same, are provided. A filter material (e.g., a discrete element in solid form) or a filter material precursor (e.g., a foamable thermoplastic composition and a blowing agent) to be introduced into a hollow interior of a softened thermoplastic material present within a mold during pipette fabrication. A pipette includes a filter element comprising foamed polymeric material within a mouthpiece region, wherein an outer portion of the filter element is bound to or encapsulated in an inner wall of the mouthpiece region. A filter material precursor may be supplied coaxially with a tubular flow of thermoplastic material into the mold, may be supplied laterally through a mold wall, or may be injected into a molten thermoplastic pipette forming material upstream of an extruder outlet.

Abstract: Provided is a method of treating patients with cluster headache comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, a method of reducing or eliminating side effects of ketamine when used in the treatment of Cluster headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of cluster headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: A method for preparing an aqueous suspension may include providing a fibrous substrate comprising cellulose having a Canadian Standard freeness equal to or less than 450 cm3, and microfibrillating the fibrous substrate in an aqueous environment by grinding in the presence of a grinding medium consisting essentially of mullite. The grinding may be carried out in the absence of grindable inorganic particulate material. The grinding medium may be present in an amount of at least about 10% by volume of the aqueous environment. The microfibrillated cellulose may have a fibre steepness of from about 20 to about 50.

Abstract: A method for producing pipettes (110, 111, 112) is provided. The method includes extruding a polymer melt into at least one mold segment of a mold assembly (120) having a plurality of mold segments to form a parison (50) or preform, wherein the plurality of mold segments (122) comprise cavities (42) that are shaped to form pipettes when in communication with the cavity of an adjacent mold segment; forming at least two pipettes in the shape of the mold segment cavities by blow-molding or vacuum forming the parison or preform, each of the at least two pipettes having proximal and distal ends; heating the pipettes to form a locally heated portion of the at least two pipettes; and separating the pipettes by cutting the locally heated portion of the at least two pipettes with separation feature (64, 66, 194, 196).

Abstract: Provided is a method of treating patients with Cluster Headache (CH) including chronic Cluster Headache (cCH) comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, which may reduce or eliminate side effects of ketamine when used in the treatment of Cluster Headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of Cluster Headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: A method for preparing an aqueous suspension may include providing a fibrous substrate comprising cellulose having a Canadian Standard freeness equal to or less than 450 cm3, and microfibrillating the fibrous substrate in an aqueous environment by grinding in the presence of a grinding medium consisting essentially of mullite. The grinding may be carried out in the absence of grindable inorganic particulate material. The grinding medium may be present in an amount of at least about 10% by volume of the aqueous environment. The microfibrillated cellulose may have a fibre steepness of from about 20 to about 50.