Abstract: Provided is a method of treating patients with cluster headache comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, a method of reducing or eliminating side effects of ketamine when used in the treatment of Cluster headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of cluster headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: Provided is a method of treating patients with Cluster Headache (CH) including chronic Cluster Headache (cCH) comprising intranasal administration to a patient in need thereof of an aqueous composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine, which may reduce or eliminate side effects of ketamine when used in the treatment of Cluster Headache, and to a composition, e.g., pharmaceutical composition, comprising a therapeutically effective amount of ketamine for use in the treatment of Cluster Headache, wherein the composition is in a nasal dosage form such as a nasal spray.

Abstract: Levetiracetam, an N-type calcium channel antagonist drug, has been discovered to be highly effective in treating migraine headaches. When administered orally on a daily basis, it reduces the adverse traits (including frequency, severity, and duration) of migraines among chronic sufferers. When injected intravenously, it was highly effective in entirely curing or greatly reducing full-blown acute migraine headaches, even among patients who could not be treated adequately by triptans or any other known drugs.