Abstract: In general, scapular tethers and methods of using scapular tethers are provided. A tether is configured to be implanted in a body of a patient and to control movement of the patient's scapula. In an exemplary embodiment, the tether is configured to be attached to at least one body structure in a patient. The tether includes a flexible member configured to, when implanted in the patient, flex in response to movement of the patient's scapula accompanying arm movement of the patient.

Abstract: As disclosed herein, inhibition of the ornithine decarboxylase 1-driven pathway can restore immunotherapeutic efficacy in lung cancer with lost STK11 function. Therefore, disclosed herein are compositions and methods for treating a lung cancer in a subject using an ornithine decarboxylase (ODC) inhibitor, such as difluoromethylornithine. In particular, disclosed is a method for using an ODC inhibitor to sensitize a lung cancer to immunotherapy. The method can involve assaying the subject for STK11 function. The method can also involve treating the subject with an immunotherapy, such as anti-PD-1/PD-L1 immunotherapy.

Abstract: Rupture fairings are disclosed. A disclosed example fairing for use with an aircraft includes a surface to at least partially define an exterior surface of the aircraft when the fairing is installed onto the aircraft, and a membrane to rupture during flight of the aircraft, where the membrane defines at least a portion of the exterior surface.

Abstract: Rupture fairings are disclosed. A disclosed example fairing for use with an aircraft includes a surface to at least partially define an exterior surface of the aircraft when the fairing is installed onto the aircraft, and a membrane to rupture during flight of the aircraft, where the membrane defines at least a portion of the exterior surface.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, which pumps have different strokes, an exit orifice, and an actuator assembly. The difference between the first stroke and the second stroke is accommodated through flexure of a flexing member in the actuator assembly. The first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: The present invention relates to a multi-component fragrance dispensing apparatus comprising at least an aqueous based composition and a volatile solvent based composition, wherein the apparatus comprises two separate containers, two separate non-spray dispensers, and one exit orifice therein. Methods of using the apparatus for providing a longer lasting fragrance is also encompassed by the present invention.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, which pumps have different strokes, an exit orifice, and an actuator assembly. The difference between the first stroke and the second stroke is accommodated through flexure of a flexing member in the actuator assembly. The first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions, at least two pumps for pumping the at least two compositions, a premix chamber containing a mixing element for mixing the two compositions, at least two channels for delivering the compositions from the reservoirs to the premix chamber, an exit orifice, optionally a swirl chamber, and an actuator.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, which pumps have different strokes, an exit orifice, and an actuator assembly. The difference between the first stroke and the second stroke is accommodated through flexure of a flexing member in the actuator assembly. The first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, an optional premix chamber for mixing the two compositions before dispensing, at least two channels for delivering the compositions from the reservoirs to the premix chamber or swirl chamber, an exit orifice, an actuator, and a lever assembly for reducing the actuation force required to activate the two pumps; wherein the first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: The present invention relates to a multi-component fragrance dispensing apparatus comprising at least an aqueous based composition and a volatile solvent based composition, wherein the apparatus comprises at least two separate containers, two separate dispensers, and two separate exit orifices therein. Methods of using the apparatus for providing a longer lasting fragrance is also encompassed by the present invention.

Abstract: The present invention relates to a portable multi-fragrance compositional dispensing system comprising at least an aqueous based composition and a volatile solvent based composition, wherein the system comprises at least two separate containers, two separate dispensers, and two separate exit orifices therein. Methods of using the system for providing a longer lasting fragrance is also encompassed by the present invention.

Abstract: The present invention relates to a multi-component fragrance dispensing apparatus comprising at least an aqueous based composition and a volatile solvent based composition, wherein the apparatus comprises two separate containers, two separate non-spray dispensers, and one exit orifice therein. Methods of using the apparatus for providing a longer lasting fragrance is also encompassed by the present invention.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions, at least two pumps for pumping the at least two compositions, a premix chamber containing a mixing element for mixing the two compositions, at least two channels for delivering the compositions from the reservoirs to the premix chamber, an exit orifice, optionally a swirl chamber, and an actuator.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, an optional premix chamber for mixing the two compositions before dispensing, at least two channels for delivering the compositions from the reservoirs to the premix chamber or swirl chamber, an exit orifice, an actuator, and a lever assembly for reducing the actuation force required to activate the two pumps; wherein the first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: A dual dispenser having two pumps associated with a first and second receptacle and a common dispenser head, said common dispenser head having an output forming a dispensing orifice, said output channel being fed with the fluid products coming out of the two pumps, such that the two pumps have actuating rods that are movable axially over travel paths of different lengths, i.e.

Abstract: A dispenser for applying at least two compositions, the dispenser including at least two reservoirs for storing the at least two compositions separately, at least two pumps for pumping the at least two compositions, which pumps have different strokes, an exit orifice, and an actuator assembly. The difference between the first stroke and the second stroke is accommodated through flexure of a flexing member in the actuator assembly. The first composition includes microcapsules and the second composition includes a volatile solvent.

Abstract: A dual dispenser having two pumps associated with a first and second receptacle and a common dispenser head, said common dispenser head having an output forming a dispensing orifice, said output channel being fed with the fluid products coming out of the two pumps, such that the two pumps have actuating rods that are movable axially over travel paths of different lengths, i.e.

Abstract: The present invention relates to a process for making a container having an integral handle, comprising the steps of: a) providing a preform (6) in a mould cavity (1); b) stretch-blow moulding the preform (6) to form an intermediate container (8) which comprises at least one, preferably two, convex bubble(s) (9); c) deforming the or each convex bubble (9) by means of an inwardly moving plug (5) to form one or more concave gripping region(s), whilst maintaining the pressure within the intermediate container (8) above 1 bar and whilst the temperature of the material in the gripping region of the intermediate container is maintained at a temperature between the glass transition temperature, Tg, and the melt temperature, Tm; d) releasing excess pressure within the container, preferably prior to withdrawing the plug (5) from within the container; and e) ejecting the finished container from the mould cavity (1, 3).

Abstract: The present invention relates to a process for making a container having an integral handle, comprising the steps of: a) providing a preform (6) in a mold cavity (1); b) stretch-blow molding the preform (6) to form an intermediate container (8) which comprises at least one, preferably two, convex bubble(s) (9); c) deforming the or each convex bubble (9) by means of an inwardly moving plug (5) to form one or more concave gripping region(s), while maintaining the pressure within the intermediate container (8) above 1 bar and while the temperature of the material in the gripping region of the intermediate container is maintained at a temperature between the glass transition temperature, Tg, and the melt temperature, Tm; d) releasing excess pressure within the container, preferably prior to withdrawing the plug (5) from within the container; and e) ejecting the finished container from the mold cavity (1, 3).