Patents by Inventor John Climax

John Climax has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising 15-HEPE and methods of using the same
    Patent number: 12274685
    Abstract: The present invention relates to the compositions comprising 15-HEPE and methods of treatment relating to same.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: April 15, 2025
    Assignee: Afimmune Limited
    Inventors: David Coughlan, John Climax
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING HEMATOLOGIC DISORDERS, AND/OR RELATED DISEASES
    Publication number: 20250017887
    Abstract: The present disclosure relates to methods of treating or preventing hematologic disorders by administration of 15-HEPE or compositions thereof.
    Type: Application
    Filed: July 25, 2024
    Publication date: January 16, 2025
    Inventors: John Climax, Moayed Hamza, Markus Weissbach, David Coughlan
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING AND/OR PREVENTING HEMATOLOGIC DISORDERS AND RELATED DISEASES
    Publication number: 20240299328
    Abstract: Compositions comprising 15-hydroxyeicosapentaenoic acid (15-HEPE) in free acid form or a pharmaceutically acceptable ester, conjugate, or salt thereof; and therapeutic methods of treating a subject comprising administering a composition comprising 15-HEPE to treat diseases including red blood cell disorders, hemoglobin disorders, bleeding disorders, and blood cancer in a subject in need thereof.
    Type: Application
    Filed: March 6, 2024
    Publication date: September 12, 2024
    Inventors: John Climax, Moayed Hamza
  • Compositions comprising 15-HEPE and methods of treating or preventing hematologic disorders, and/or related diseases
    Patent number: 12076304
    Abstract: The present disclosure relates to methods of treating or preventing hematologic disorders by administration of 15-HEPE or compositions thereof.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: September 3, 2024
    Assignee: Afimmune Limited
    Inventors: John Climax, Moayed Hamza, Markus Weissbach, David Coughlan
  • Compositions comprising oxo-derivatives of fatty acids and methods of making and using same
    Patent number: 12017986
    Abstract: The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing fibrosis, skin disorders, inflammation, kidney disease or renal dysfunction in a subject in need thereof by administering 15-oxo-EPA and/or 15-oxo-DGLA.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: June 25, 2024
    Assignee: DS Biopharma Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF USING THE SAME
    Publication number: 20230106655
    Abstract: The present invention relates to the compositions comprising 15-HEPE and methods of treatment relating to same.
    Type: Application
    Filed: May 20, 2022
    Publication date: April 6, 2023
    Inventors: David Coughlan, John Climax
  • COMPOSITIONS COMPRISING 15-OHEPA AND METHODS OF USING THE SAME
    Publication number: 20220347147
    Abstract: The present invention relates to the compositions, formulations and methods of treating fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their sequelae by administration of 15-OHEPA.
    Type: Application
    Filed: March 23, 2022
    Publication date: November 3, 2022
    Inventors: Jonathan Rowe, Kevin Duffy, John Climax
  • Pharmaceutical compositions comprising DGLA and use of same
    Patent number: 11478442
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: October 25, 2022
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • Compositions Comprising Oxo-Derivatives of Fatty Acids and Methods of Making and Using Same
    Publication number: 20220324788
    Abstract: The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing fibrosis, skin disorders, inflammation, kidney disease or renal dysfunction in a subject in need thereof by administering 15-oxo-EPA and/or 15-oxo-DGLA.
    Type: Application
    Filed: November 16, 2021
    Publication date: October 13, 2022
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING HEMATOLOGIC DISORDERS, AND/OR RELATED DISEASES
    Publication number: 20220265593
    Abstract: The present disclosure relates to methods of treating or preventing hematologic disorders by administration of 15-HEPE or compositions thereof.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: John Climax, Moayed Hamza, Markus Weissbach, David Coughlan
  • PHARMACEUTICAL COMPOSITIONS COMPRISING 15-HETRE AND METHODS OF USE THEREOF
    Publication number: 20220133669
    Abstract: Provided herein are pharmaceutical compositions comprising 15-HETrE and methods of using the same to treat a variety of conditions and disorders.
    Type: Application
    Filed: October 29, 2021
    Publication date: May 5, 2022
    Inventors: John Climax, David Coughlan, Bill Downes, Tien Nghiem, Markus Weissbach, Moayed Hamza
  • METHODS OF TREATING INFLAMMATORY, FIBROTIC, AND PROLIFERATIVE CONDITIONS USING COMPOSITIONS COMPRISING DGLA AND/OR 15-HETRE, AND ASSOCIATED METHODS AND COMPOSITIONS
    Publication number: 20210322354
    Abstract: The present disclosure provides orally and/or topically deliverable pharmaceutical compositions comprising DGLA or a derivative thereof and/or 15-HETrE or a derivative thereof and methods of using same to treat a variety of conditions, diseases, and disorders, including but not limited to inflammatory, fibrotic, and proliferative conditions, diseases, and disorders.
    Type: Application
    Filed: November 30, 2020
    Publication date: October 21, 2021
    Inventors: John Climax, David Coughlan, Markus Weissbach, Moayed Hamza
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING HEMATOLOGIC DISORDERS, AND/OR RELATED DISEASES
    Publication number: 20210315851
    Abstract: The present disclosure relates to methods of treating or preventing hematologic disorders by administration of 15-HEPE or compositions thereof.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 14, 2021
    Inventors: John Climax, Moayed Hamza, Markus Weissbach, David Coughlan
  • COMPOSITIONS COMPRISING 15-OHEPA AND METHODS OF USING THE SAME
    Publication number: 20210244697
    Abstract: The present invention relates to the compositions, formulations and methods of treating fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their sequelae by administration of 15-OHEPA.
    Type: Application
    Filed: April 16, 2021
    Publication date: August 12, 2021
    Inventors: Jonathan Rowe, Kevin Duffy, John Climax
  • COMPOSITIONS COMPRISING 15-OHEPA AND METHODS OF USING THE SAME
    Publication number: 20210228524
    Abstract: The present invention relates to the compositions, formulations and methods of treating fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their sequelae by administration of 15-OHEPA.
    Type: Application
    Filed: September 16, 2020
    Publication date: July 29, 2021
    Inventors: Jonathan Rowe, Kevin Duffy, John Climax
  • Compositions Comprising Oxo-Derivatives of Fatty Acids and Methods of Making and Using Same
    Publication number: 20210230094
    Abstract: The present disclosure provides 15-oxo-EPA and 15-oxo-DGLA, compositions comprising 15-oxo-EPA and/or 15-oxo-DGLA, and methods of treating and/or preventing fibrosis, skin disorders, inflammation, kidney disease or renal dysfunction in a subject in need thereof by administering 15-oxo-EPA and/or 15-oxo-DGLA.
    Type: Application
    Filed: January 13, 2020
    Publication date: July 29, 2021
    Inventors: Mehar Manku, John Climax, David Coughlan
  • COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING CANCER AND NEUROLOGIC DISEASE
    Publication number: 20210085628
    Abstract: The present disclosure provides compositions comprising 15-HEPE and methods of using same for treating and/or preventing cancer and neurological diseases in a subject in need thereof.
    Type: Application
    Filed: June 5, 2020
    Publication date: March 25, 2021
    Inventors: John Climax, David Coughlan
  • Pharmaceutical compositions comprising DGLA and use of same
    Patent number: 10849870
    Abstract: The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: December 1, 2020
    Inventors: Mehar Manku, John Climax, David Coughlan, James Dunne
  • COMPOSITIONS COMPRISING 15-HEPE AND/OR 15-HETrE AND METHODS OF TREATING OR PREVENTING CARDIOMETABOLIC DISEASE, METABOLIC SYNDROME, AND/OR RELATED DISEASES
    Publication number: 20200360331
    Abstract: The present disclosure relates to methods of treating or preventing metabolic syndrome and/or cardiometabolic disease by administration of 15-HEPE, 15-HETrE, or compositions thereof.
    Type: Application
    Filed: July 19, 2019
    Publication date: November 19, 2020
    Inventors: John Climax, David Coughlan
  • Compositions comprising 15-HEPE and methods of using the same
    Patent number: 10813903
    Abstract: The present invention relates to the compositions, formulations and methods of treating fatty liver disorders, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their sequelae by administration of 15-OHEPA.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: October 27, 2020
    Assignee: Afimmune Limited
    Inventors: Jonathan Rowe, Kevin Duffy, John Climax