Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

Abstract: Disclosed herein are catheters having multiple coil layers, and associated systems and methods. In some embodiments, a catheter includes an inner liner, a plurality of wires over the inner liner, and an outer sheath over the wires. The wires are coiled about a longitudinal axis of the catheter in a first direction to form a first coil layer over the inner liner, and the wires are coiled about the longitudinal axis in a second direction, opposite the first direction, over the first coil layer to form a second coil layer over the first coil layer. The wires each include a continuous/self-terminating end portion wherein the wire switches from the first direction to the second direction and transitions from the inner coil layer to the outer coil layer.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

Abstract: Systems and methods for forming a tubular braid are disclosed here-in. A braiding system configured in accordance with embodiments of the present technology can include, for example, an upper drive unit, a lower drive unit, a mandrel coaxial with the upper and lower drive units, and a plurality of tubes extending between the upper drive unit and the lower drive unit. Each tube can be configured to receive individual filaments for forming the tubular braid, and the upper and lower drive units can act in synchronization to move the tubes (and the filaments contained within those tubes) in three distinct motions: (i) radially inward toward a central axis, (ii) radially outward away from the central axis, and (iii) rotationally about the central axis, to cross the filaments over and under one another to form the tubular braid on the mandrel.

Abstract: Disclosed herein are clot treatment systems with filtering syringes, and associated devices and methods. The filtering syringe can be coupled to a catheter subsystem insertable within a patient. The filtering syringe can aspirate material (e.g., clot material, blood, etc.) from a patient via the catheter subsystem. The filtering syringe can include a plunger assembly, and the plunger assembly can include one or more filters. Each of the filters can be configured to (i) allow at least a first portion of aspirated material (e.g., blood) to pass through at least one of the filters, and (ii) prevent at least a second portion of the aspirated material (e.g., clot material) from passing through at least one of the filters. In some embodiments, the filtering syringe is fluidly coupled to a filtered material subsystem that can fluidly couple the filtering syringe to the patient or another suitable fluid outflow location.

Abstract: Disclosed herein are aspiration catheters having grooved inner surfaces for removing clot material from the vasculature of a patient, and associated systems and methods. In some embodiments, an aspiration catheter can include a proximal terminus, a distal terminus, and an inner surface defining a lumen. The inner surface includes at least one groove formed therein and that extends from the distal terminus at least partially toward the proximal terminus. When clot material is aspirated through the aspiration catheter, the at least one groove can provide a leak path past the clot material to improve the ingestion of the clot material through the catheter and inhibit clogging.

Abstract: Disclosed herein are devices for mechanically removing clot and/or other material from implants implanted in the vasculature of a patient, and associated systems and methods. In some embodiments, a system for removing clot material from an implant—such as a stent—includes a clot treatment device configured to be deployed within the stent, a handle, and a first elongate member and a second elongate member coupling the clot treatment device to the handle. The first elongate member couples a first end portion of the clot treatment device to the handle, and the second elongate member couples a second end portion of the clot treatment device to an actuator of the handle. Actuation of the actuator is configured to move the second elongate member relative to the first elongate member to move the first and second end portions toward one another to radially expand the clot treatment device.

Abstract: Automatically-locking syringes are disclosed herein. A syringe in accordance with embodiments of the present technology can include (i) a barrel, (ii) a plunger slidably positioned within the barrel, and (iii) a lock plate coupled to the barrel. The plunger also extends through an opening in the lock plate, and a biasing member is configured to bias the lock plate to a locking position. When the plunger is moved from a depressed position to a withdrawn position, the lock feature engages the lock plate to drive the lock plate away from the locking position to thereby permit the lock feature to pass through the opening in the lock plate. After the lock feature passes through the opening, the biasing member drives the lock plate to the locking position to inhibit movement of the plunger from the withdrawn position to the depressed position.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. In one embodiment, a funnel catheter assembly includes an outer shaft and an inner shaft extending through and coaxial with the outer shaft. An expandable funnel can be coupled to a distal portion of the inner shaft. The funnel catheter assembly further includes a control assembly operably coupled to the proximal portion of the outer shaft and configured to move the outer shaft between a first position and a second position. In the first position, the outer shaft is positioned at least partially over the funnel to constrain the funnel in a compressed state. In the second position, the outer shaft is retracted proximally relative to the funnel such that the funnel can expand to an expanded state.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. In one embodiment, a system includes a coring element for coring and separating the clot material. The coring element can comprise a unitary structure having a first region, a second region, a third region, and a fourth region. The first region is adjacent to a proximal portion of the unitary structure and includes a first mouth configured to core and separate the clot material. The second region is distal of the first region, generally tubular, and includes a first plurality of interconnected struts. The third region is distal of the second region and includes a second mouth configured to core and separate the vascular thrombus. The fourth region is distal of the third region, generally tubular, and includes a second plurality of interconnected struts.

Abstract: A wound retractor comprising an outer ring, an inner ring, and a flexible sheath extending therebetween is described, wherein the inner ring has the strength, rigidity and bounce back characteristics of a solid injection-molded ring yet is manufactured by extrusion techniques described herein with a 20-30% reduction in materials, resulting in reduced manufacturing costs.