Abstract: The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. The methods and compositions described herein utilize a throughput approach that is able to simultaneously measure binding affinity and link the binding affinity to the identity (e.g., sequence) of the aptamer.

Abstract: The present invention provides a method and device for optically extracting discrete features of an object. With this method and device, small regions of interest or features within a relatively large object are optically extracted and collated into a single, condensed image. The condensed image contains all of the features in the original object, but not the parts of the object that are between the features. Thus, the optically extracted features can be viewed at high resolution, but in a limited field of view. Examples of objects that may be optically extracted according to the invention include spots of biomaterial on a biochip, material in wells of a microtiter plate, etc. In addition, this device and method can be used for non-planar objects. In this case, the device and method allow simultaneous visualization of spatially separated features on a surface of a 3-dimensional object.

Abstract: The present invention provides a method and device for optically extracting discrete features of an object. With this method and device, small regions of interest or features within a relatively large object are optically extracted and collated into a single, condensed image. The condensed image contains all of the features in the original object, but not the parts of the object that are between the features. Thus, the optically extracted features can be viewed at high resolution, but in a limited field of view. Examples of objects that may be optically extracted according to the invention include spots of biomaterial on a biochip, material in wells of a microtiter plate, etc. In addition, this device and method can be used for non-planar objects. In this case, the device and method allow simultaneous visualization of spatially separated features on a surface of a 3-dimensional object.

Abstract: A system for providing real-time measurements of constriction pressure applied by the inner surface of a body lumen, such as a sphincter, includes a probe comprising an elongated core member having a matrix of pressure transducer regions distributed over the surface of the elongated core member. The preferred matrix of pressure transducer regions is addressed by a first inner array of substantially parallel electrically conductive strips substantially conformed circumferentially to at least a portion of the elongated core member, the first array being disposed in overlapping relationship with a second outer array of substantially parallel electrically conductive strips, and substantially conformed axially to at least the same portion of the elongated core member, so as to provide a matrix of intersection regions.

Abstract: An inwardly swinging door is provided with a threshhold assembly that effectively seals against entry of driven water and air. The threshhold assembly includes a sloping subpan having an upstanding rear wall. An integral outer threshhold member and upper pan are connected to and above the subpan. The upper pan provides a primary seal at the front edge of the door bottom and defines a primary sill floor that cooperates with the flexible wiper blades carried by the door bottom to define secondary barriers. The inner side of the door bottom carries a final seal which bars entry of air that may be driven through drainage holes provided in the subpan and interconnecting the interior of the subpan with the interior of the upper pan.